Safimestomig

Investigational

Approval Year

Substance Class	Protein
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type	IGG4\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	LFQ9PP64F2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

6MW3211

Preferred Name

English

Safimestomig

Official Name

English

immunoglobulin G4-kappa, anti-[Homo sapiens CD47 (CD47 molecule, integrin associated protein, IAP, MER6, OA3)] and anti-[Homo sapiens CD274 (programmed cell death 1 ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, PDCD1LG1)], humanized monoclonal antibo

Common Name

English

Immunoglobulin G4 [232-proline,360-lysine,439-arginine], bispecific, anti-(human CD47 antigen) (human-Mus musculus monoclonal 6MW3211 ?4-chain), (230?228?),(233?225?)-bis(disulfide) with immunoglobulin G4 [227-proline,438-glutamic acid] anti-(human progr

Common Name

English

safimestomig [INN]

Common Name

English

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Code System

Code

Type

Description

FDA UNII

LFQ9PP64F2

PRIMARY

SMS_ID

300000056835

PRIMARY

INN

13102

PRIMARY

NCI_THESAURUS

C184379

PRIMARY

CAS

2911590-72-0

PRIMARY

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Subunit 0

Subunit 1

Subunit 2

Subunit 3

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From	To
1_22	1_96
2_22	2_96
2_133	4_214
2_146	2_202
2_260	2_320

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Glycosylation Type

MAMMALIAN

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Glycosylation Link Type	Site
N	1_301
N	2_296

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Related Record

Type

Details


					LFQ9PP64F2

Safimestomig

ACTIVE MOIETY

Comments:

6MW3211 is a bispecific IgG4 antibody designed to selectively bind to CD47 and PD-L1 on tumor cells to attenuate CD47-SIRP? signaling and block the PD-1/PD-L1 checkpoint inhibition, and thereby triggering stronger tumor cell phagocytosis and enhanced T cell activation

Amount:

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Name	Property Type	Amount
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL	148169.68 DALTONS (average) 0K, 0K; G0F, G0F
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL	147966.49 DALTONS (average) 0K, 0K; G0F-GN, G0F
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL	145280.98 DALTONS (average) Deglycosylated, 0K, 0K
Molecular Formula	CHEMICAL	ESTIMATED C6459H9982O2029N1708S46
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL	148331.82 DALTONS (average) 0K, 0K; G0F, G1F

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