PYRIDONE-6

CC(C)(C)C1=NC2=C3C=CNC(=O)C3=C4C=C(F)C=CC4=C2N1

InChIKey=VNDWQCSOSCCWIP-UHFFFAOYSA-N

InChI=1S/C18H16FN3O/c1-18(2,3)17-21-14-10-5-4-9(19)8-12(10)13-11(15(14)22-17)6-7-20-16(13)23/h4-8H,1-3H3,(H,20,23)(H,21,22)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Potency
Tyrosine-protein kinase JAK1 38 Target ID: P52332 Gene ID: NA Gene Symbol: Jak1 Target Organism: Mus musculus (Mouse) Sources: https://www.ncbi.nlm.nih.gov/pubmed/11934592	Inhibitor 8297	15.0 nM [IC50]
Tyrosine-protein kinase JAK2 55 Target ID: O60674 Gene ID: 3717.0 Gene Symbol: JAK2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/11934592	Inhibitor 8297	1.0 nM [IC50]
Tyrosine-protein kinase JAK3 27 Target ID: P52333 Gene ID: 3718.0 Gene Symbol: JAK3 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/11934592	Inhibitor 8297	5.0 nM [IC50]
Non-receptor tyrosine-protein kinase TYK2 1 Target ID: P29597 Gene ID: 7297.0 Gene Symbol: TYK2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/11934592	Inhibitor 8297	1.0 nM [IC50]

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:40:01 GMT 2023` Edited by `admin` on `Sat Dec 16 11:40:01 GMT 2023`
Record UNII	LDX3F0CCST
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

PYRIDONE-6

Common Name

English

CMP-6

Common Name

English

PAN-JAK INHIBITOR P6

Common Name

English

7H-BENZ(H)IMIDAZO(4,5-F)ISOQUINOLIN-7-ONE, 2-(1,1-DIMETHYLETHYL)-9-FLUORO-1,6-DIHYDRO-

Systematic Name

English

JAK INHIBITOR I

Common Name

English

2-(1,1-DIMETHYLETHYL)-9-FLUORO-1,6-DIHYDRO-7H-BENZ(H)IMIDAZO(4,5-F)ISOQUINOLIN-7-ONE

Systematic Name

English

MERCK-5

Common Name

English

Code System Code Type Description

DRUG BANK

DB04716