Velaglucerase Beta

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 21:22:11 GMT 2025` Edited by `admin` on `Wed Apr 02 21:22:11 GMT 2025`
Protein Type	ENZYME
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	L9RX488DET
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Glucocerebrosidase (recombinant human clone CAN 103)

Preferred Name

English

Velaglucerase Beta

Official Name

English

velaglucerase beta [INN]

Common Name

English

human lysosomal acid glucosylceramidase (EC 3.2.1.45, betaglucosylceramidase 1 (beta-GC), beta-glucocerebrosidase), produced in Chinese hamster ovary (CHO) K1 cells, glycoform beta

Common Name

English

Code System Code Type Description

CAS

2725857-55-4

Created by admin on Wed Apr 02 21:22:11 GMT 2025 , Edited by admin on Wed Apr 02 21:22:11 GMT 2025

PRIMARY

SMS_ID

300000054755

Created by admin on Wed Apr 02 21:22:11 GMT 2025 , Edited by admin on Wed Apr 02 21:22:11 GMT 2025

PRIMARY

FDA UNII

L9RX488DET

Created by admin on Wed Apr 02 21:22:11 GMT 2025 , Edited by admin on Wed Apr 02 21:22:11 GMT 2025

PRIMARY

NCI_THESAURUS

C207011

Created by admin on Wed Apr 02 21:22:11 GMT 2025 , Edited by admin on Wed Apr 02 21:22:11 GMT 2025

PRIMARY

INN

12835

Created by admin on Wed Apr 02 21:22:11 GMT 2025 , Edited by admin on Wed Apr 02 21:22:11 GMT 2025

PRIMARY

From	To
1_4	1_16
1_18	1_23

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_19
N	1_59
N	1_146
N	1_270
N	1_462

Related Record Type Details


					N69L6LM4QU

LYSOSOMAL ACID GLUCOSYLCERAMIDASE

TARGET->ENZYME REPLACEMENT

Amount:

Related Record Type Details


					L9RX488DET

Velaglucerase Beta

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_19] [1_59] [1_146] [1_270] [1_463]	SITE_SPECIFIC	N	Amount:	Asparagine-MAN-5 Glycan	54WDZ2CLN3

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL