PSEUDOTROPINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H15NO
Molecular Weight	141.2108
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1[C@H]2CC[C@@H]1C[C@@H](O)C2

InChI

InChIKey=CYHOMWAPJJPNMW-RNLVFQAGSA-N

InChI=1S/C8H15NO/c1-9-6-2-3-7(9)5-8(10)4-6/h6-8,10H,2-5H2,1H3/t6-,7+,8-

HIDE SMILES / InChI

Molecular Formula	C8H15NO
Molecular Weight	141.2108
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10387002

Pseudotropine (ψ-tropine, or psi-tropine) is an isomer of tropine. Pseudotropine is formed during NADPH-dependent reduction of the 3-carbonyl group of tropinone to a beta-hydroxyl group. Tropinone reductase-II is an enzyme responsible for this transformation. It is known, that tropinone reductase-II is also a key enzyme in the biosynthetic pathway of tropane alkaloids, which include medicinally important compounds such as hyoscyamine (atropine) and cocaine.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Virtual combinatorial syntheses and computational screening of new potential anti-herpes compounds.	1999 Aug 26	10464017
The new neuromuscular blocking agents: do they offer any advantages?	2001 Dec	11878696
Neuromuscular pharmacology of TAAC3, a new nondepolarizing muscle relaxant with rapid onset and ultrashort duration of action.	2002 Apr	11916790
Structure-activity relationships among derivatives of dicarboxylic acid esters of tropine.	2002 Oct	12441175
Calystegines in wild and cultivated Erythroxylum species.	2005 Jun	15907958
Quaternary derivatives of granatanol diesters: potent, ultrashort acting non-depolarizing neuromuscular relaxants.	2006 Jul 4	16516930
The functional divergence of short-chain dehydrogenases involved in tropinone reduction.	2008 May	18221363
Treatment of Cushing disease: overview and recent findings.	2010 Oct 21	21063461

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:58:30 GMT 2023` Edited by `admin` on `Sat Dec 16 09:58:30 GMT 2023`
Record UNII	L9Q7Z9D09L
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PSEUDOTROPINE

Common Name

English

PSEUDOTROPINE [MI]

Common Name

English

PSEUDOTROPANOL

Common Name

English

.PSI.-TROPINE

Common Name

English

8-AZABICYCLO(3.2.1)OCTAN-3-OL, 8-METHYL-, (3-EXO)-

Common Name

English

3-PSEUDOTROPANOL

Common Name

English

NSC-43871

Code

English

3.BETA.-TROPANOL

Common Name

English

Code System Code Type Description

ECHA (EC/EINECS)

205-226-5