| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H13BrN2O2S |
| Molecular Weight | 377.256 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
BrC1=CC=C(C2=CC=CC=C12)S(=O)(=O)NCC3=CC=CC=N3
InChI
InChIKey=GJSDYQXOSHKOGX-UHFFFAOYSA-N
InChI=1S/C16H13BrN2O2S/c17-15-8-9-16(14-7-2-1-6-13(14)15)22(20,21)19-11-12-5-3-4-10-18-12/h1-10,19H,11H2
| Molecular Formula | C16H13BrN2O2S |
| Molecular Weight | 377.256 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Pyrabactin is a synthetic sulfonamide that functions both as selective ABA receptor agonist and antagonist. Abscisic acid (ABA) is an endogenous small molecule growth inhibitor and regulator of plant stress physiology. Pyrabactin mimics abscisic acid (ABA). It acts through Pyrabactin Resistance 1 (PYR1), the founding member of a family of START proteins called PYR/PYLs, which are necessary for both pyrabactin and ABA signaling in vivo. Pyrabactin an important tool for protecting crops against drought and cold weather.
Originator
Approval Year
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
PubMed
Patents
Sample Use Guides
Consistent with the in planta observations, pyrabactin cannot directly inhibit the phosphatase activity of ABI1, but achieves the inhibition through PYL proteins. Further characterization revealed that pyrabactin exhibits an IC50 (1.14 ± 0.07 μm) ∼10-fold higher than that of ABA (93.8 ± 8.4 nm).