SULFOSALICYLIC ACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H6O6S
Molecular Weight	218.184
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)C1=C(O)C=CC(=C1)S(O)(=O)=O

InChI

InChIKey=YCPXWRQRBFJBPZ-UHFFFAOYSA-N

InChI=1S/C7H6O6S/c8-6-2-1-4(14(11,12)13)3-5(6)7(9)10/h1-3,8H,(H,9,10)(H,11,12,13)

HIDE SMILES / InChI

Molecular Formula	C7H6O6S
Molecular Weight	218.184
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25611486 | https://www.ncbi.nlm.nih.gov/pubmed/18682649

Sulfosalicylic acid dihydrate is a polyfunctional metal chelating ligand that may be used as a metal scavenger.to form metal coordination complexes. Sulfosalicylic acid forms proton-transfer dye complexes with diazo compounds such as 4-(phenyldiazenyl)aniline. Proteins are precipitated upon complexation with 5-Sulfosalicylic acid, allowing the qualitative analysis of the resultant turbidity formed in a sample by these complexes leaving solution. Protein precipitation with 5-Sulfosalicylic acid has also been employed as a preparative measure for removing proteins prior to chromatographic analysis.

Approval Year

PubMed

Title	Date	PubMed
Protonation and complex formation of 5-sulfosalicylate in NaCl, CaCl2 and MgCl2 aqueous media. Speciation in synthetic seawater.	2002 May-Jun	12125460
Hydrogen bonding in proton-transfer compounds of 5-sulfosalicylic acid with bicyclic heteroaromatic Lewis bases.	2004 Aug	15295192
Poly[aquaneodymium(III)-mu5-2-oxido-5-sulfonatobenzoato].	2004 Dec	15579958
De novo biosynthesis and radiolabeling of mammalian digitalis-like factors.	2004 Mar	14981028
Comparison of gene expression signatures of diamide, H2O2 and menadione exposed Aspergillus nidulans cultures--linking genome-wide transcriptional changes to cellular physiology.	2005 Dec 20	16368011
Separation of aceclofenac and diclofenac in human plasma by free zone capillary electrophoresis using N-methyl-D-glucamine as an effective electrolyte additive.	2005 Mar	15734304
High-throughput metal susceptibility testing of microbial biofilms.	2005 Oct 3	16202124
In vitro growth inhibition of bloodstream forms of Trypanosoma brucei and Trypanosoma congolense by iron chelators.	2006 Aug 16	16914038
Influence of the reaction conditions on the self-assembly of lead(II) 5-sulfosalicylate coordination polymers with chelating amine ligands.	2006 Sep 18	16961387
The PDE4 inhibitor rolipram reverses object memory impairment induced by acute tryptophan depletion in the rat.	2007 Jun	17265077
Tunable separation of anions and cations by column switching in ion chromatography.	2007 Mar 15	19071477
Two salts of 5-sulfosalicylic acid and 3-aminopyridine.	2007 Nov	17989492
R2(2)(8) motifs in Aminopyrimidine sulfonate/carboxylate interactions: crystal structures of pyrimethaminium benzenesulfonate monohydrate (2:2:1) and 2-amino-4,6-dimethylpyrimidinium sulfosalicylate dihydrate (4:2:2).	2007 Nov 13	17999751
Different effects of angiotensin converting enzyme inhibitors on endothelin-1 and nitric oxide balance in human vascular endothelial cells: evidence of an oxidant-sensitive pathway.	2008	19079593
The three-dimensional hydrogen-bonded framework structure in the 1:1 proton-transfer compound of the drug quinacrine with 5-sulfosalicylic acid.	2008 Aug	18682649
Liquid chromatographic fluorescence determination of amino acids in plasma and urine after derivatization with phanquinone.	2008 Feb	18004736
Pyrazine-diium bis-(3-carb-oxy-4-hydroxy-benzene-sulfonate) dihydrate.	2008 Jun 19	21202920
1-Hydroxy-ethyl-2-methyl-5-nitro-imidazolium 3-carb-oxy-4-hydroxy-benzene-sulfonate.	2008 Jun 25	21202961
3,3'-(p-Phenyl-enedimethyl-ene)di-imidazol-1-ium bis-(3-carb-oxy-4-hydroxy-benzene-sulfonate) dihydrate.	2009 Jan 23	21581963
Guanidinium quinoline-2-carboxyl-ate.	2009 Nov 25	21578928
4-(2-Hydroxy-ethyl)anilinium 3-carb-oxy-4-hydroxy-benzene-sulfonate monohydrate.	2009 Nov 25	21578917
Reduction of ischemic and oxidative damage to the hypothalamus by hyperbaric oxygen in heatstroke mice.	2010	20625500
2-Amino-5-chloro-pyridinium 3-carb-oxy-4-hy-droxy-benzene-sulfonate.	2010 Aug 18	21588670
Simultaneous stacking of cationic and anionic compounds in single run capillary zone electrophoresis by two-end field amplified sample injection.	2010 Aug 27	20655053
2-Amino-5-bromo-pyridinium 3-carb-oxy-4-hy-droxy-benzene-sulfonate.	2010 Aug 28	21588738
Spectrum of HNF1A somatic mutations in hepatocellular adenoma differs from that in patients with MODY3 and suggests genotoxic damage.	2010 Jul	20393147
2-Amino-5-methyl-pyridinium 3-carb-oxy-4-hy-droxy-benzene-sulfonate.	2010 Jul 31	21588438
Salts of aromatic amines: crystal structures, spectroscopic and non-linear optical properties.	2010 Nov	20813579

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:00:24 UTC 2023` Edited by `admin` on `Fri Dec 15 16:00:24 UTC 2023`
Record UNII	L8XED79U3U
Record Status	`Validated (UNII)`
Record Version

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Related Record	Type

Name

Type

Language

SULFOSALICYLIC ACID

Systematic Name

English

NSC-190565

Code

English

2-HYDROXYBENZOIC-5-SULFONIC ACID

Common Name

English

2-HYDROXY-5-SULFOBENZOIC ACID

Systematic Name

English

5-SULFOSALICYLIC ACID

Systematic Name

English

SALICYLSULFONIC ACID

Systematic Name

English

SULFOSALICYLIC ACID [MI]

Common Name

English

3-CARBOXY-4-HYDROXYBENZENESULFONIC ACID

Systematic Name

English

Sulfosalicylic acid [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257