U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Details

Stereochemistry ACHIRAL
Molecular Formula C7H6O6S
Molecular Weight 218.184
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SULFOSALICYLIC ACID

SMILES

OC(=O)C1=C(O)C=CC(=C1)S(O)(=O)=O

InChI

InChIKey=YCPXWRQRBFJBPZ-UHFFFAOYSA-N
InChI=1S/C7H6O6S/c8-6-2-1-4(14(11,12)13)3-5(6)7(9)10/h1-3,8H,(H,9,10)(H,11,12,13)

HIDE SMILES / InChI

Molecular Formula C7H6O6S
Molecular Weight 218.184
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Sulfosalicylic acid dihydrate is a polyfunctional metal chelating ligand that may be used as a metal scavenger.to form metal coordination complexes. Sulfosalicylic acid forms proton-transfer dye complexes with diazo compounds such as 4-(phenyldiazenyl)aniline. Proteins are precipitated upon complexation with 5-Sulfosalicylic acid, allowing the qualitative analysis of the resultant turbidity formed in a sample by these complexes leaving solution. Protein precipitation with 5-Sulfosalicylic acid has also been employed as a preparative measure for removing proteins prior to chromatographic analysis.

Approval Year

PubMed

PubMed

TitleDatePubMed
Hepatic uptake of synthetic chlorogenic acid derivatives by the organic anion transport proteins.
2001 Jan
Determination of selenium sulfide using 1,3-dibromo-5,5-dimethylhydantoin (DBH). Analytical methods of pharmacopeias with DBH in respect to environmental and economical concern Part 11.
2002 Apr 15
Effects of Fe(III) chemical speciation on dissimilatory Fe(III) reduction by Shewanella putrefaciens.
2002 Feb 1
Mutational analysis of the metabolism of 2,6-naphthalenedisulfonate by Pigmentiphaga sp. NDS-2.
2003
Potentiometric membrane sensors based on zirconyl(IV) phthalocyanine for detection of sulfosalicylic acid.
2004 May 28
Equilibrium studies on chromium(III) complexes of salicylic acid and salicylic acid derivatives in aqueous solution.
2004 Nov
Indirect photometric assay determination of gabapentin in bulk drug and capsules by capillary electrophoresis.
2004 Nov 15
Stoichiometry, stability constants and coordination geometry of Eu(III) 5-sulfosalicylate complex in aqueous system-A TRLIFS study.
2004 Nov 7
Simultaneous determination of L-arginine and its mono- and dimethylated metabolites in human plasma by high-performance liquid chromatography-mass spectrometry.
2004 Oct
The role of benzoate secreted by Desulfotomaculum acetoxidans DSM 771 in sulfate uptake.
2005
Comparison of gene expression signatures of diamide, H2O2 and menadione exposed Aspergillus nidulans cultures--linking genome-wide transcriptional changes to cellular physiology.
2005 Dec 20
Hydrogen bonding in 1:1 proton-transfer compounds of 5-sulfosalicylic acid with 4-X-substituted anilines (X = F, Cl or Br).
2005 Feb
Phenolic compounds, sodium salicylate and related compounds, as inhibitors of tumor cell growth and inducers of apoptosis in mouse leukemia L1210 cells.
2005 Jan-Feb
Phase I study of pegylated liposomal doxorubicin and the multidrug-resistance modulator, valspodar.
2005 Jul 11
Photocatalytic degradation of p-nitrophenol on nanometer size titanium dioxide surface modified with 5-sulfosalicylic acid.
2005 Oct
High-throughput metal susceptibility testing of microbial biofilms.
2005 Oct 3
Layered structures in proton-transfer compounds of 5-sulfosalicylic acid with the aromatic polyamines 2,6-diaminopyridine and 1,4-phenylenediamine.
2005 Sep
In vitro growth inhibition of bloodstream forms of Trypanosoma brucei and Trypanosoma congolense by iron chelators.
2006 Aug 16
Serial separation of cations and anions by ion chromatography using the peak parking technique and sulfosalicylic acid as the eluent.
2006 Feb
Lack of evidence for reduced prefrontal cortical serotonin and dopamine efflux after acute tryptophan depletion.
2007 Dec
2-Carboxy-quinolinium-2,4,6-trinitro-benzene-sulfonate-quinolinium-2-carboxyl-ate (1/1/1).
2007 Dec 6
Tunable separation of anions and cations by column switching in ion chromatography.
2007 Mar 15
Different effects of angiotensin converting enzyme inhibitors on endothelin-1 and nitric oxide balance in human vascular endothelial cells: evidence of an oxidant-sensitive pathway.
2008
Synthesis and characterization of conducting polyaniline 5-sulfosalicylate nanotubes.
2008 Apr 2
Liquid chromatographic fluorescence determination of amino acids in plasma and urine after derivatization with phanquinone.
2008 Feb
The toxic function of cesium 5-sulfosalicylate based on the investigation of its trans-erythrocytes membrane behaviors and morphological properties.
2008 Feb 15
Pyrazine-diium bis-(3-carb-oxy-4-hydroxy-benzene-sulfonate) dihydrate.
2008 Jun 19
1-Hydroxy-ethyl-2-methyl-5-nitro-imidazolium 3-carb-oxy-4-hydroxy-benzene-sulfonate.
2008 Jun 25
4-Carboxy-pyridinium 3-carb-oxy-4-hydroxy-benzene-sulfonate.
2008 Jun 7
In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II.
2008 Oct 15
4,4'-Methyl-enedianilinium bis-(3-carb-oxy-4-hydroxy-benzene-sulfonate) monohydrate.
2008 Sep 17
Poly[[diaqua(μ(2)-4,4'-dipyridyl sulfide-κN:N')(4,4'-dipyridyl sulfide-κN)(2-hydroxy-5-sulfonatobenzoato-κO)nickel(II)] dihydrate].
2008 Sep 20
4-(4-Carb-oxy-1,3-thia-zol-2-yl)pyridinium 3-carb-oxy-4-hydroxy-benzene-sulfonate dihydrate.
2008 Sep 30
Bis[μ-1,2-bis-(1H-imidazol-1-ylmeth-yl)benzene-κN:N]disilver(I) 3-carboxyl-ato-4-hydroxy-benzene-sulfonate methanol solvate trihydrate.
2009 Aug 8
3,3'-(p-Phenyl-enedimethyl-ene)di-imidazol-1-ium bis-(3-carb-oxy-4-hydroxy-benzene-sulfonate) dihydrate.
2009 Jan 23
Diaqua-bis(1,10-phenanthroline-κN,N')zinc(II) 2-hydr-oxy-5-sulfonatobenzoate tetra-hydrate.
2009 Jan 31
Pharmacokinetics of acute tryptophan depletion using a gelatin-based protein in male and female Wistar rats.
2009 Jul
COOH-terminal truncations and site-directed mutations enhance thermostability and chaperone-like activity of porcine alphaB-crystallin.
2009 Jul 28
Poly[aqua-(μ(5)-2-oxido-4-sulfonato-benzoato)lanthanum(III)].
2009 Mar 11
o-Phenyl-enediammonium bis-(3-carb-oxy-4-hydroxy-benzene-sulfonate).
2009 Nov 21
Guanidinium quinoline-2-carboxyl-ate.
2009 Nov 25
4-(2-Hydroxy-ethyl)anilinium 3-carb-oxy-4-hydroxy-benzene-sulfonate monohydrate.
2009 Nov 25
Hexaaqua-zinc(II) bis-(4-hydroxy-benzene-sulfonate) dihydrate.
2009 Oct 10
Aqua-(2-hydr-oxy-5-sulfonatobenzoato-κO)bis-(2-phenyl-1H-1,3,7,8-tetra-aza-cyclo-penta-[l]phenanthrene-κN,N)zinc(II).
2009 Oct 3
Reduction of ischemic and oxidative damage to the hypothalamus by hyperbaric oxygen in heatstroke mice.
2010
Simultaneous stacking of cationic and anionic compounds in single run capillary zone electrophoresis by two-end field amplified sample injection.
2010 Aug 27
Effect of dietary fats on oxidative-antioxidative status of blood in rats.
2010 Jul
[Hydrogen bis-(1,2,4-triazole)] 1,2,4-triazolium bis-(3-carb-oxy-4-hy-droxy-benzene-sulfonate) 1,2,4-triazole disolvate.
2010 Jul 17
Nigericin-mediated liposome loading of topotecan: is nigericin a potential drug release regulator?
2010 Oct 31
Patents
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:16:02 GMT 2025
Edited
by admin
on Mon Mar 31 18:16:02 GMT 2025
Record UNII
L8XED79U3U
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
Name Type Language
NSC-190565
Preferred Name English
SULFOSALICYLIC ACID
MI   WHO-DD  
Systematic Name English
2-HYDROXYBENZOIC-5-SULFONIC ACID
Common Name English
2-HYDROXY-5-SULFOBENZOIC ACID
Systematic Name English
5-SULFOSALICYLIC ACID
Systematic Name English
SALICYLSULFONIC ACID
Systematic Name English
SULFOSALICYLIC ACID [MI]
Common Name English
3-CARBOXY-4-HYDROXYBENZENESULFONIC ACID
Systematic Name English
Sulfosalicylic acid [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C257
Created by admin on Mon Mar 31 18:16:02 GMT 2025 , Edited by admin on Mon Mar 31 18:16:02 GMT 2025
Code System Code Type Description
NCI_THESAURUS
C84186
Created by admin on Mon Mar 31 18:16:02 GMT 2025 , Edited by admin on Mon Mar 31 18:16:02 GMT 2025
PRIMARY
MERCK INDEX
m10364
Created by admin on Mon Mar 31 18:16:02 GMT 2025 , Edited by admin on Mon Mar 31 18:16:02 GMT 2025
PRIMARY Merck Index
ChEMBL
CHEMBL229241
Created by admin on Mon Mar 31 18:16:02 GMT 2025 , Edited by admin on Mon Mar 31 18:16:02 GMT 2025
PRIMARY
RXCUI
1370604
Created by admin on Mon Mar 31 18:16:02 GMT 2025 , Edited by admin on Mon Mar 31 18:16:02 GMT 2025
PRIMARY
PUBCHEM
7322
Created by admin on Mon Mar 31 18:16:02 GMT 2025 , Edited by admin on Mon Mar 31 18:16:02 GMT 2025
PRIMARY
FDA UNII
L8XED79U3U
Created by admin on Mon Mar 31 18:16:02 GMT 2025 , Edited by admin on Mon Mar 31 18:16:02 GMT 2025
PRIMARY
WIKIPEDIA
5-SULFOSALICYLIC ACID
Created by admin on Mon Mar 31 18:16:02 GMT 2025 , Edited by admin on Mon Mar 31 18:16:02 GMT 2025
PRIMARY
CAS
97-05-2
Created by admin on Mon Mar 31 18:16:02 GMT 2025 , Edited by admin on Mon Mar 31 18:16:02 GMT 2025
PRIMARY
NSC
190565
Created by admin on Mon Mar 31 18:16:02 GMT 2025 , Edited by admin on Mon Mar 31 18:16:02 GMT 2025
PRIMARY
ECHA (EC/EINECS)
202-555-6
Created by admin on Mon Mar 31 18:16:02 GMT 2025 , Edited by admin on Mon Mar 31 18:16:02 GMT 2025
PRIMARY
CHEBI
68555
Created by admin on Mon Mar 31 18:16:02 GMT 2025 , Edited by admin on Mon Mar 31 18:16:02 GMT 2025
PRIMARY
SMS_ID
300000018052
Created by admin on Mon Mar 31 18:16:02 GMT 2025 , Edited by admin on Mon Mar 31 18:16:02 GMT 2025
PRIMARY
EPA CompTox
DTXSID7059145
Created by admin on Mon Mar 31 18:16:02 GMT 2025 , Edited by admin on Mon Mar 31 18:16:02 GMT 2025
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
SUB_CONCEPT->SUBSTANCE
SALT/SOLVATE -> PARENT
SOLVATE->ANHYDROUS
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY