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Details

Stereochemistry ACHIRAL
Molecular Formula C7H6O6S
Molecular Weight 218.184
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SULFOSALICYLIC ACID

SMILES

OC(=O)C1=C(O)C=CC(=C1)S(O)(=O)=O

InChI

InChIKey=YCPXWRQRBFJBPZ-UHFFFAOYSA-N
InChI=1S/C7H6O6S/c8-6-2-1-4(14(11,12)13)3-5(6)7(9)10/h1-3,8H,(H,9,10)(H,11,12,13)

HIDE SMILES / InChI
Molecular Formula C7H6O6S
Molecular Weight 218.184
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Sulfosalicylic acid dihydrate is a polyfunctional metal chelating ligand that may be used as a metal scavenger.to form metal coordination complexes. Sulfosalicylic acid forms proton-transfer dye complexes with diazo compounds such as 4-(phenyldiazenyl)aniline. Proteins are precipitated upon complexation with 5-Sulfosalicylic acid, allowing the qualitative analysis of the resultant turbidity formed in a sample by these complexes leaving solution. Protein precipitation with 5-Sulfosalicylic acid has also been employed as a preparative measure for removing proteins prior to chromatographic analysis.

Approval Year

2011
562
PubMed

PubMed

TitleDatePubMed
Hepatic uptake of synthetic chlorogenic acid derivatives by the organic anion transport proteins.
2001 Jan
Determination of selenium sulfide using 1,3-dibromo-5,5-dimethylhydantoin (DBH). Analytical methods of pharmacopeias with DBH in respect to environmental and economical concern Part 11.
2002 Apr 15
Mutational analysis of the metabolism of 2,6-naphthalenedisulfonate by Pigmentiphaga sp. NDS-2.
2003
Poly[aquaneodymium(III)-mu5-2-oxido-5-sulfonatobenzoato].
2004 Dec
Potentiometric membrane sensors based on zirconyl(IV) phthalocyanine for detection of sulfosalicylic acid.
2004 May 28
Equilibrium studies on chromium(III) complexes of salicylic acid and salicylic acid derivatives in aqueous solution.
2004 Nov
Indirect photometric assay determination of gabapentin in bulk drug and capsules by capillary electrophoresis.
2004 Nov 15
The role of benzoate secreted by Desulfotomaculum acetoxidans DSM 771 in sulfate uptake.
2005
Comparison of gene expression signatures of diamide, H2O2 and menadione exposed Aspergillus nidulans cultures--linking genome-wide transcriptional changes to cellular physiology.
2005 Dec 20
Hydrogen bonding in 1:1 proton-transfer compounds of 5-sulfosalicylic acid with 4-X-substituted anilines (X = F, Cl or Br).
2005 Feb
Separation of aceclofenac and diclofenac in human plasma by free zone capillary electrophoresis using N-methyl-D-glucamine as an effective electrolyte additive.
2005 Mar
Development of a kinetic metabolic model: application to Catharanthus roseus hairy root.
2006 Apr
In vitro growth inhibition of bloodstream forms of Trypanosoma brucei and Trypanosoma congolense by iron chelators.
2006 Aug 16
Serial separation of cations and anions by ion chromatography using the peak parking technique and sulfosalicylic acid as the eluent.
2006 Feb
Syntheses, structures, and characterizations of four new lead(II) 5-sulfosalicylate complexes with both chelating and bridging neutral ligands.
2007 Aug 6
2-Carboxy-quinolinium-2,4,6-trinitro-benzene-sulfonate-quinolinium-2-carboxyl-ate (1/1/1).
2007 Dec 6
Two salts of 5-sulfosalicylic acid and 3-aminopyridine.
2007 Nov
R2(2)(8) motifs in Aminopyrimidine sulfonate/carboxylate interactions: crystal structures of pyrimethaminium benzenesulfonate monohydrate (2:2:1) and 2-amino-4,6-dimethylpyrimidinium sulfosalicylate dihydrate (4:2:2).
2007 Nov 13
The toxic function of cesium 5-sulfosalicylate based on the investigation of its trans-erythrocytes membrane behaviors and morphological properties.
2008 Feb 15
Pyrazine-diium bis-(3-carb-oxy-4-hydroxy-benzene-sulfonate) dihydrate.
2008 Jun 19
1-Hydroxy-ethyl-2-methyl-5-nitro-imidazolium 3-carb-oxy-4-hydroxy-benzene-sulfonate.
2008 Jun 25
In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II.
2008 Oct 15
Poly[[diaqua(μ(2)-4,4'-dipyridyl sulfide-κN:N')(4,4'-dipyridyl sulfide-κN)(2-hydroxy-5-sulfonatobenzoato-κO)nickel(II)] dihydrate].
2008 Sep 20
Probiotics prevent intestinal barrier dysfunction in acute pancreatitis in rats via induction of ileal mucosal glutathione biosynthesis.
2009
Pharmacokinetics of acute tryptophan depletion using a gelatin-based protein in male and female Wistar rats.
2009 Jul
Proton transfer versus nontransfer in compounds of the diazo-dye precursor 4-(phenyldiazenyl)aniline (aniline yellow) with strong organic acids: the 5-sulfosalicylate and the dichroic benzenesulfonate salts, and the 1:2 adduct with 3,5-dinitrobenzoic acid.
2009 Oct
Resolving the role of plant glutamate dehydrogenase. I. In vivo real time nuclear magnetic resonance spectroscopy experiments.
2009 Oct
Aqua-(2-hydr-oxy-5-sulfonatobenzoato-κO)bis-(2-phenyl-1H-1,3,7,8-tetra-aza-cyclo-penta-[l]phenanthrene-κN,N)zinc(II).
2009 Oct 3
Protective effect of transgenic expression of porcine heat shock protein 70 on hypothalamic ischemic and oxidative damage in a mouse model of heatstroke.
2009 Sep 3
Removal of transition metal ions from aqueous solutions by adsorption onto a novel silica gel matrix composite adsorbent.
2009 Sep 30
Enhancement of L-3-hydroxybutyryl-CoA dehydrogenase activity and circulating ketone body levels by pantethine. Relevance to dopaminergic injury.
2010 Apr 23
2-Amino-5-chloro-pyridinium 3-carb-oxy-4-hy-droxy-benzene-sulfonate.
2010 Aug 18
Simultaneous stacking of cationic and anionic compounds in single run capillary zone electrophoresis by two-end field amplified sample injection.
2010 Aug 27
2-Amino-5-bromo-pyridinium 3-carb-oxy-4-hy-droxy-benzene-sulfonate.
2010 Aug 28
Acetaminophen induces apoptosis in rat cortical neurons.
2010 Dec 10
Reduction of oxidative cellular damage by overexpression of the thioredoxin TRX2 gene improves yield and quality of wine yeast dry active biomass.
2010 Feb 12
Effect of dietary fats on oxidative-antioxidative status of blood in rats.
2010 Jul
Spectrum of HNF1A somatic mutations in hepatocellular adenoma differs from that in patients with MODY3 and suggests genotoxic damage.
2010 Jul
[Hydrogen bis-(1,2,4-triazole)] 1,2,4-triazolium bis-(3-carb-oxy-4-hy-droxy-benzene-sulfonate) 1,2,4-triazole disolvate.
2010 Jul 17
2-Amino-4-methyl-pyridinium 3-carb-oxy-4-hy-droxy-benzene-sulfonate monohydrate.
2010 Jul 24
2-Amino-5-methyl-pyridinium 3-carb-oxy-4-hy-droxy-benzene-sulfonate.
2010 Jul 31
Salts of aromatic amines: crystal structures, spectroscopic and non-linear optical properties.
2010 Nov
Identification of protonation state by XPS, solid-state NMR, and DFT: characterization of the nature of a new theophylline complex by experimental and computational methods.
2010 Nov 11
A simple colorimetric FIA method for the determination of pyrite oxidation rates.
2010 Oct 15
Polynuclear complexes of macrocyclic oxamide with 5-sulfosalicylate: syntheses, crystal structures and magnetic properties.
2010 Oct 28
Nigericin-mediated liposome loading of topotecan: is nigericin a potential drug release regulator?
2010 Oct 31
Patents

Patents

20040019143
3
JP2000157296A
3
JPH08114599A
5
JPH09176206A
5
JPH10293131A
5
JPS55149131A
5
JPS5849779A
3
JPS60123408A
5
JPS629272A
5
Substance Class Chemical
Created
by admin
on Wed Jul 05 23:28:29 UTC 2023
Edited
by admin
on Wed Jul 05 23:28:29 UTC 2023
Record UNII
L8XED79U3U
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
Name Type Language
SULFOSALICYLIC ACID
MI   WHO-DD  
Systematic Name English
NSC-190565
Code English
2-HYDROXYBENZOIC-5-SULFONIC ACID
Common Name English
2-HYDROXY-5-SULFOBENZOIC ACID
Systematic Name English
5-SULFOSALICYLIC ACID
Systematic Name English
SALICYLSULFONIC ACID
Systematic Name English
SULFOSALICYLIC ACID [MI]
Common Name English
3-CARBOXY-4-HYDROXYBENZENESULFONIC ACID
Systematic Name English
Sulfosalicylic acid [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C257
Created by admin on Wed Jul 05 23:28:29 UTC 2023 , Edited by admin on Wed Jul 05 23:28:29 UTC 2023
Code System Code Type Description
NCI_THESAURUS
C84186
Created by admin on Wed Jul 05 23:28:29 UTC 2023 , Edited by admin on Wed Jul 05 23:28:29 UTC 2023
PRIMARY
MERCK INDEX
M10364
Created by admin on Wed Jul 05 23:28:29 UTC 2023 , Edited by admin on Wed Jul 05 23:28:29 UTC 2023
PRIMARY Merck Index
ChEMBL
CHEMBL229241
Created by admin on Wed Jul 05 23:28:29 UTC 2023 , Edited by admin on Wed Jul 05 23:28:29 UTC 2023
PRIMARY
RXCUI
1370604
Created by admin on Wed Jul 05 23:28:29 UTC 2023 , Edited by admin on Wed Jul 05 23:28:29 UTC 2023
PRIMARY
PUBCHEM
7322
Created by admin on Wed Jul 05 23:28:29 UTC 2023 , Edited by admin on Wed Jul 05 23:28:29 UTC 2023
PRIMARY
FDA UNII
L8XED79U3U
Created by admin on Wed Jul 05 23:28:29 UTC 2023 , Edited by admin on Wed Jul 05 23:28:29 UTC 2023
PRIMARY
WIKIPEDIA
5-SULFOSALICYLIC ACID
Created by admin on Wed Jul 05 23:28:29 UTC 2023 , Edited by admin on Wed Jul 05 23:28:29 UTC 2023
PRIMARY
CAS
97-05-2
Created by admin on Wed Jul 05 23:28:29 UTC 2023 , Edited by admin on Wed Jul 05 23:28:29 UTC 2023
PRIMARY
NSC
190565
Created by admin on Wed Jul 05 23:28:29 UTC 2023 , Edited by admin on Wed Jul 05 23:28:29 UTC 2023
PRIMARY
ECHA (EC/EINECS)
202-555-6
Created by admin on Wed Jul 05 23:28:29 UTC 2023 , Edited by admin on Wed Jul 05 23:28:29 UTC 2023
PRIMARY
CHEBI
68555
Created by admin on Wed Jul 05 23:28:29 UTC 2023 , Edited by admin on Wed Jul 05 23:28:29 UTC 2023
PRIMARY
SMS_ID
300000018052
Created by admin on Wed Jul 05 23:28:29 UTC 2023 , Edited by admin on Wed Jul 05 23:28:29 UTC 2023
PRIMARY
EPA CompTox
DTXSID7059145
Created by admin on Wed Jul 05 23:28:29 UTC 2023 , Edited by admin on Wed Jul 05 23:28:29 UTC 2023
PRIMARY
Related Record Type Details
Structure of METHENAMINE SULFOSALICYLATE MONOHYDRATE
SALT/SOLVATE -> PARENT
SULFOSALICYLATE
SUB_CONCEPT->SUBSTANCE
Structure of METHENAMINE SULFOSALICYLATE
SALT/SOLVATE -> PARENT
Structure of SULFOSALICYLIC ACID DIHYDRATE
SOLVATE->ANHYDROUS
Structure of SULFOSALICYLIC ACID DIHYDRATE
SALT/SOLVATE -> PARENT
Structure of DISODIUM SULFOSALICYLATE
SALT/SOLVATE -> PARENT
Structure of MECLOCYCLINE SULFOSALICYLATE
SALT/SOLVATE -> PARENT
Structure of METHACYCLINE 5-SULFOSALICYLATE
SALT/SOLVATE -> PARENT
Structure of DOXYCYCLINE SULFOSALICYLATE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of SULFOSALICYLIC ACID
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