Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C5H6N2O4 |
| Molecular Weight | 158.1121 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
N[C@H](C(O)=O)C1=CC(=O)NO1
InChI
InChIKey=IRJCBFDCFXCWGO-BYPYZUCNSA-N
InChI=1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)/t4-/m0/s1
| Molecular Formula | C5H6N2O4 |
| Molecular Weight | 158.1121 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Role of the anterodorsal and anteroventral nuclei of the thalamus in spatial memory in the rat. | 2002-04-15 |
|
| Regioselective lithiation and functionalization of 3-(benzyloxy)isothiazole: application to the synthesis of thioibotenic acid. | 2002-04-05 |
|
| Excitotoxic median raphe lesions aggravate working memory storage performance deficits caused by scopolamine infusion into the dentate gyrus of the hippocampus in the inhibitory avoidance task in rats. | 2002-04 |
|
| Effects of acute and subchronic administration of dexefaroxan, an alpha(2)-adrenoceptor antagonist, on memory performance in young adult and aged rodents. | 2002-04 |
|
| Determination of acetylcholine and dopamine content in thalamus and striatum after excitotoxic lesions of the pedunculopontine tegmental nucleus in rats. | 2002-03-29 |
|
| mRNA expression alterations of inward rectifier potassium channels in rat brain with cholinergic impairment. | 2002-03-29 |
|
| Effects of excitotoxic median raphe lesion on working memory deficits produced by the dorsal hippocampal muscarinic receptor blockade in the inhibitory avoidance in rats. | 2002-03-15 |
|
| Transgenic mice expressing the human presenilin 1 gene demonstrate enhanced hippocampal reorganization following entorhinal cortex lesions. | 2002-03-15 |
|
| Selective activation of central subtypes of the nicotinic acetylcholine receptor has opposite effects on neonatal excitotoxic brain injuries. | 2002-03 |
|
| Selective antagonists at group I metabotropic glutamate receptors: synthesis and molecular pharmacology of 4-aryl-3-isoxazolol amino acids. | 2002-02-14 |
|
| Behavioral effects of excitotoxic lesions of ventral medial prefrontal cortex in the rat are hemisphere-dependent. | 2002-02-08 |
|
| Cell dynamics of calretinin-immunoreactive neurons in the rostral migratory stream after ibotenate-induced lesions in the forebrain. | 2002-02 |
|
| Hippocampal dysfunction and behavioral deficit in the water maze in mice: an unresolved issue? | 2002-01-01 |
|
| Effects of brain histamine on memory deficit induced by nucleus basalis-lesion in rats. | 2002-01 |
|
| Electrolytic and ibotenic acid lesions of the nucleus basalis magnocellularis interrupt long-term retention, but not acquisition of two-way active avoidance, in rats. | 2002-01 |
|
| Melatoninergic neuroprotection of the murine periventricular white matter against neonatal excitotoxic challenge. | 2002-01 |
|
| Effects of alpha(2)-adrenoceptor agonists on perinatal excitotoxic brain injury: comparison of clonidine and dexmedetomidine. | 2002-01 |
|
| Neuroprotective effects of leptin in vivo and in vitro. | 2001-12-21 |
|
| Subthalamo-pallido-striatal axis: a feedback system in the basal ganglia. | 2001-12-04 |
|
| Cholinergic and noncholinergic septal neurons modulate strategy selection in spatial learning. | 2001-12 |
|
| Unilateral lesion of the nigrostriatal pathway induces an increase of neuronal activity of the pedunculopontine nucleus, which is reversed by the lesion of the subthalamic nucleus in the rat. | 2001-12 |
|
| The effects of excitotoxic lesions of the pedunculopontine tegmental nucleus on conditioned place preference to 4%, 12% and 20% sucrose solutions. | 2001-12 |
|
| Long-term synaptic alteration in the rat hippocampal CA3 field following an entorhinal cortex lesion. | 2001-12 |
|
| Unilateral lesions of the pedunculopontine nucleus do not alleviate subthalamic nucleus-mediated anticipatory responding in a delayed sensorimotor task in the rat. | 2001-11-29 |
|
| Effects of ketamine on different types of anxiety/fear and related memory in rats with lesions of the median raphe nucleus. | 2001-11-23 |
|
| Differentiation of GABA(A) receptors in subcortical heterotopias: subunit distribution of displaced cortex reflects original commitment. | 2001-11-16 |
|
| Adaptation and habituation to an open field and responses to various stressful events in animals with neonatal lesions in the amygdala or ventral hippocampus. | 2001-11-09 |
|
| Role of Barrington's nucleus in the activation of rat locus coeruleus neurons by colonic distension. | 2001-11-02 |
|
| Involvement of the bed nucleus of the stria terminalis in hippocampal cholinergic system-mediated activation of the hypothalamo--pituitary--adrenocortical axis in rats. | 2001-10-19 |
|
| Reduction in opioid- and cannabinoid-induced antinociception in rhesus monkeys after bilateral lesions of the amygdaloid complex. | 2001-10-15 |
|
| Persistence of meal-entrained circadian rhythms following area postrema lesions in the rat. | 2001-10 |
|
| Forebrain muscarinic control of micturition reflex in rats. | 2001-10 |
|
| Inhibitory learning tests of conditioned stimulus associability in rats with lesions of the amygdala central nucleus. | 2001-10 |
|
| Subthalamic nucleus lesions are neuroprotective against terminal 6-OHDA-induced striatal lesions and restore postural balancing reactions. | 2001-10 |
|
| Fastigial nucleus-mediated respiratory responses depend on the medullary gigantocellular nucleus. | 2001-10 |
|
| Prolonged survival of axons terminating within lesions of cat visual cortex. | 2001-09-21 |
|
| Region-specific decrease in 5-HT1A and 5-HT1B binding sites after intra-hippocampal ibotenic acid injections in the rat. | 2001-09-07 |
|
| Sustained, long-lasting inhibition of nitric oxide synthase aggravates the neural damage in some models of excitotoxic brain injury. | 2001-09-01 |
|
| Strain differences in the behavioural outcome of neonatal ventral hippocampal lesions are determined by the postnatal environment and not genetic factors. | 2001-09 |
|
| Spatial strategy elaboration in egocentric and allocentric tasks following medial prefrontal cortex lesions in the rat. | 2001-08-31 |
|
| Stimulation of the subthalamic vasodilator area and fastigial nucleus independently protects the brain against focal ischemia. | 2001-08-31 |
|
| Parabrachial nucleus lesions block taste and attenuate flavor preference and aversion conditioning in rats. | 2001-08 |
|
| Tianeptine and its enantiomers: effects on spatial memory in rats with medial septum lesions. | 2001-08 |
|
| Ibotenate injections into the pre- and parasubiculum provide partial protection against kainate-induced epileptic damage in layer III of rat entorhinal cortex. | 2001-07 |
|
| Lateral parabrachial nucleus lesions in the rat: neophobia and conditioned taste aversion. | 2001-06 |
|
| Ibotenic acid lesions in the pedunculopontine region result in recovery of visual orienting in the hemianopic cat. | 2001 |
|
| MRI-Based evaluation of locus and extent of neurotoxic lesions in monkeys. | 2001 |
|
| Dissociation between the attentional functions mediated via basal forebrain cholinergic and GABAergic neurons. | 2001 |
|
| Ibotenate lesion of the ventromedial hypothalamus lowers hyperthermic effects of prostaglandin E1. | 2001 |
|
| Medullary neurones regulate hypothalamic corticotropin-releasing factor cell responses to an emotional stressor. | 2001 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:09:41 GMT 2025
by
admin
on
Mon Mar 31 22:09:41 GMT 2025
|
| Record UNII |
L61L2F576C
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| Record Status |
Validated (UNII)
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| Record Version |
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Common Name | English | ||
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| Code System | Code | Type | Description | ||
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6603885
Created by
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L61L2F576C
Created by
admin on Mon Mar 31 22:09:41 GMT 2025 , Edited by admin on Mon Mar 31 22:09:41 GMT 2025
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25690-45-3
Created by
admin on Mon Mar 31 22:09:41 GMT 2025 , Edited by admin on Mon Mar 31 22:09:41 GMT 2025
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PRIMARY |