1,1-Dioxo-5-phenyl-1,2,5-thiadiazolidin-3-one

O=C1CN(C2=CC=CC=C2)S(=O)(=O)N1

InChIKey=LDCZCUKQWRZSDT-UHFFFAOYSA-N

InChI=1S/C8H8N2O3S/c11-8-6-10(14(12,13)9-8)7-4-2-1-3-5-7/h1-5H,6H2,(H,9,11)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Protein-tyrosine phosphatase 1B 34 Target ID: CHEMBL335 Sources: http://www.chemexpress.cn/612530-44-6.htm \| https://www.ncbi.nlm.nih.gov/pubmed/15863305	Inhibitor 8504		1.6 mM [IC50]

PubMed

Title	Date	PubMed
A comparative QSAR on 1,2,5-thiadiazolidin-3-one 1,1-dioxide compounds as selective inhibitors of human serine proteinases.	2011-11	21908217
Structure-based design of protein tyrosine phosphatase-1B inhibitors.	2005-05-16	15863305
Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates.	2000-05	10882012
Potent and specific inhibition of human leukocyte elastase, cathepsin G and proteinase 3 by sulfone derivatives employing the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold.	1998-06	9681132

Substance Class	Chemical Created by `admin` on `Wed Apr 02 05:48:37 GMT 2025` Edited by `admin` on `Wed Apr 02 05:48:37 GMT 2025`
Record UNII	L4SBH33TJR
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

1,1-Dioxo-5-phenyl-1,2,5-thiadiazolidin-3-one

Systematic Name

English

1,1-BIS(OXIDANYLIDENE)-5-PHENYL-1,2,5-THIADIAZOLIDIN-3-ONE

Preferred Name

English

1,2,5-Thiadiazolidin-3-one, 5-phenyl-, 1,1-dioxide

Systematic Name

English

Code System Code Type Description

FDA UNII

L4SBH33TJR

Created by admin on Wed Apr 02 05:48:37 GMT 2025 , Edited by admin on Wed Apr 02 05:48:37 GMT 2025

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CAS

612530-44-6

Created by admin on Wed Apr 02 05:48:37 GMT 2025 , Edited by admin on Wed Apr 02 05:48:37 GMT 2025

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PUBCHEM

4369452

Created by admin on Wed Apr 02 05:48:37 GMT 2025 , Edited by admin on Wed Apr 02 05:48:37 GMT 2025

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