Details
Stereochemistry | RACEMIC |
Molecular Formula | C29H38N2O4 |
Molecular Weight | 478.623 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CC(C[C@H]3NCCC4=CC(OC)=C(OC)C=C34)=C(CC)CN1CCC5=CC(OC)=C(OC)C=C25
InChI
InChIKey=XXLZPUYGHQWHRN-RPBOFIJWSA-N
InChI=1S/C29H38N2O4/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24/h13-16,24-25,30H,6-12,17H2,1-5H3/t24-,25+/m1/s1
Molecular Formula | C29H38N2O4 |
Molecular Weight | 478.623 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Oral dehydroemetine dihydrochloride (+/-) (Mebadin) was found useful both as a tissue and contact amoebicide. It is much less toxic and more active than emetine and can be given in larger doses and for longer periods with safety. Owing to the quick excretion, repeat courses can be given at short intervals, as necessary, without danger. No serious side effects were noted particularly with the oral form and it was far better tolerated by children, who received relatively higher dosage than most adults. The only contra-indication is for patients with manifest decompensation of vital organs, or fevers. Mebadin injection and Mebadin tablets are discontinued products.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
HIV-1 and HIV-2 reverse transcriptases: a comparative study of sensitivity to inhibition by selected natural products. | 1992 May 29 |
|
Treatment of experimental pneumocystosis: review of 7 years of experience and development of a new system for classifying antimicrobial drugs. | 1992 Sep |
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 05:30:52 GMT 2023
by
admin
on
Sat Dec 16 05:30:52 GMT 2023
|
Record UNII |
L36LY97UH4
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
1986-67-0
Created by
admin on Sat Dec 16 05:30:52 GMT 2023 , Edited by admin on Sat Dec 16 05:30:52 GMT 2023
|
PRIMARY | |||
|
129414
Created by
admin on Sat Dec 16 05:30:52 GMT 2023 , Edited by admin on Sat Dec 16 05:30:52 GMT 2023
|
PRIMARY | |||
|
L36LY97UH4
Created by
admin on Sat Dec 16 05:30:52 GMT 2023 , Edited by admin on Sat Dec 16 05:30:52 GMT 2023
|
PRIMARY | |||
|
121523-30-6
Created by
admin on Sat Dec 16 05:30:52 GMT 2023 , Edited by admin on Sat Dec 16 05:30:52 GMT 2023
|
NON-SPECIFIC STEREOCHEMISTRY | |||
|
21022
Created by
admin on Sat Dec 16 05:30:52 GMT 2023 , Edited by admin on Sat Dec 16 05:30:52 GMT 2023
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
ENANTIOMER -> RACEMATE |
|
||
|
SALT/SOLVATE -> PARENT |