Rapaprutug

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 20:56:13 GMT 2025` Edited by `admin` on `Wed Apr 02 20:56:13 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	L24FCW2BQH
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ZMA-001

Preferred Name

English

Rapaprutug

Official Name

English

rapaprutug [INN]

Common Name

English

Immunoglobulin G1, anti-(human lysyl-tRNA synthase 1) (human monoclonal ZMA001 ?1-chain), disulfide with human monoclonal ZMA001 ?-chain, dimer

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens KARS1 (lysyltRNA synthetase 1)], Homo sapiens monoclonal antibody (apaprutug)

Common Name

English

ZMA001

Code

English

sapiens IGHV3-23*01 (92.9%) -(IGHD) -IGHJ4*01 (100%), CDRIMGT [8.8.9] (26-33.51-58.97-105)) (1-116) -Homo sapiens IGHG1*01 (100%) G1m17,1 CH1 K120, CH3 D12, L14 (CH1 K120 (213) (117-214), hinge 1-15 (215-229), CH2 (230-339), CH3 D12 (355), L14 (357) (340

Common Name

English

Code System Code Type Description

FDA UNII

L24FCW2BQH

Created by admin on Wed Apr 02 20:56:13 GMT 2025 , Edited by admin on Wed Apr 02 20:56:13 GMT 2025

PRIMARY

CAS

2994192-38-8

Created by admin on Wed Apr 02 20:56:13 GMT 2025 , Edited by admin on Wed Apr 02 20:56:13 GMT 2025

PRIMARY

INN

13352

Created by admin on Wed Apr 02 20:56:13 GMT 2025 , Edited by admin on Wed Apr 02 20:56:13 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_143	2_199
2_219	4_217
2_260	2_320
1_143	1_199
2_366	2_424
3_22	3_89
3_137	3_197
4_22	4_89
4_137	4_197
1_219	3_217
1_225	2_225
1_228	2_228
1_260	1_320
1_366	1_424

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_296
N	2_296

Related Record Type Details


					L24FCW2BQH

Rapaprutug

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	E	Amount:	PIDOLIC ACID	SZB83O1W42
AMINO_ACID_SUBSTITUTION	[3_1] [4_1]	N-TERMINUS	Q		PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_446] [2_446]	C-TERMINUS	K	Amount:	LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL