U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Tue Apr 01 20:22:10 GMT 2025
Edited
by admin
on Tue Apr 01 20:22:10 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
L23181O7GB
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HEMOGLOBIN S
Preferred Name English
HEMOGLOBULIN S
Common Name English
HBS
Common Name English
HB S
Common Name English
HEMOGLOBULIN, SICKLED
Common Name English
HB-S
Common Name English
SICKLED HEMOGLOBULIN
Common Name English
Code System Code Type Description
FDA UNII
L23181O7GB
Created by admin on Tue Apr 01 20:22:10 GMT 2025 , Edited by admin on Tue Apr 01 20:22:10 GMT 2025
PRIMARY
Related Record Type Details
ACTIVATOR -> TARGET
GBT021601 binds to HbS and increases its oxygen (O2) affinity, thereby stabilizing the oxygenated hemoglobin (oxyHb) state and inhibiting HbS polymerization
INHIBITOR OF AGGREGATION->TARGET

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [2_63] [2_92] HEME HISTIDINE COMPLEX OXYGENATED F5FTW4DR2Y
AMINO_ACID_SUBSTITUTION [4_58] [4_87] HEME HISTIDINE COMPLEX OXYGENATED F5FTW4DR2Y
AMINO_ACID_SUBSTITUTION [1_63] [1_92] HEME HISTIDINE COMPLEX OXYGENATED F5FTW4DR2Y
AMINO_ACID_SUBSTITUTION [3_58] [3_87] HEME HISTIDINE COMPLEX OXYGENATED F5FTW4DR2Y
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL