PIVEKIMAB SUNIRINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 22:52:29 GMT 2025` Edited by `admin` on `Tue Apr 01 22:52:29 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	L15LO3W1XX
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

IMGN-632

Preferred Name

English

PIVEKIMAB SUNIRINE

Official Name

English

IMGN632

Code

English

IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS IL3RA (INTERLEUKIN 3 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN 3 RECEPTOR, ALPHA (LOW AFFINITY), CD123)), MONOCLONAL ANTIBODY, CONJUGATED WITH SULFONATED DGN549-C, A CYTOTOXIC INDOLOBENZODIAZEPINE DIMER BONDED TO A P

Common Name

English

AN ANTIBODY DRUG CONJUGATE CONSISTING OF HUMANIZED ANTI-CD123 ANTIBODY G4723A LINKED WITH DNA ALKYLATING AGENT DGN549C FOR AML AND OTHER CD123-POS. MALIGNANCIES

Common Name

English

Pivekimab sunirine [WHO-DD]

Common Name

English

PIVEKIMAB SUNIRINE [USAN]

Common Name

English

HUMANISED IgG1 KAPPA ANTI-CD123 MONOCLONAL ANTIBODY G4723AB - SULFONATED DGN549-C CONJUGATE IMGN632

Common Name

English

pivekimab sunirine [INN]

Common Name

English

Code System Code Type Description

SMS_ID

300000001484

Created by admin on Tue Apr 01 22:52:29 GMT 2025 , Edited by admin on Tue Apr 01 22:52:29 GMT 2025

PRIMARY

INN

11695

Created by admin on Tue Apr 01 22:52:29 GMT 2025 , Edited by admin on Tue Apr 01 22:52:29 GMT 2025

PRIMARY

CAS

2417174-95-7

Created by admin on Tue Apr 01 22:52:29 GMT 2025 , Edited by admin on Tue Apr 01 22:52:29 GMT 2025

PRIMARY

USAN

JK-169

Created by admin on Tue Apr 01 22:52:29 GMT 2025 , Edited by admin on Tue Apr 01 22:52:29 GMT 2025

PRIMARY

NCI_THESAURUS

C184834

Created by admin on Tue Apr 01 22:52:29 GMT 2025 , Edited by admin on Tue Apr 01 22:52:29 GMT 2025

PRIMARY

FDA UNII

L15LO3W1XX

Created by admin on Tue Apr 01 22:52:29 GMT 2025 , Edited by admin on Tue Apr 01 22:52:29 GMT 2025

PRIMARY

CAS

2364499-35-2

Created by admin on Tue Apr 01 22:52:29 GMT 2025 , Edited by admin on Tue Apr 01 22:52:29 GMT 2025

NO STRUCTURE GIVEN

From	To
4_134	4_194
2_371	2_429
2_265	2_325
3_134	3_194
2_22	2_96
2_148	2_204
1_148	1_204
2_224	4_214
1_224	3_214
1_233	2_233
1_230	2_230
1_22	1_96
3_23	3_88
4_23	4_88
1_265	1_325
1_371	1_429

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_301
N	2_301

Related Record Type Details


					3JW47OGM6P

INTERLEUKIN-3 RECEPTOR SUBUNIT ALPHA

TARGET->LIGAND

Amount:

Related Record Type Details


					L15LO3W1XX

PIVEKIMAB SUNIRINE

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_446] [2_446]	SITE_SPECIFIC		Amount:	CYSTEINYL-SULFONATED-DGN-549C	NN3OD2WL2Z
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	SITE_SPECIFIC			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL