| Stereochemistry | ACHIRAL |
| Molecular Formula | C14H16ClO5PS |
| Molecular Weight | 362.766 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOP(=S)(OCC)OC1=CC=C2C(C)=C(Cl)C(=O)OC2=C1
InChI
InChIKey=BXNANOICGRISHX-UHFFFAOYSA-N
InChI=1S/C14H16ClO5PS/c1-4-17-21(22,18-5-2)20-10-6-7-11-9(3)13(15)14(16)19-12(11)8-10/h6-8H,4-5H2,1-3H3
| Molecular Formula | C14H16ClO5PS |
| Molecular Weight | 362.766 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Coumaphos is an organophosphate insecticide used against ectoparasites. It was approved by FDA for the control of gastrointestinal roundworms in cattle (Purina brand name). It was also used in medicated feed against internal parasites (Ascaidia galli, Capilleria obsignata and Heterakis gallinarum) in layer chickens (Meldane brand name). However, coumaphos is highly toxic to birds. Sever acute toxicity and eventual death were caused in hens after they were given oral doses of 10mg/kg for 1-8 days.The oral LD50 for coumaphos is 3mg/kg in wildbirds, 29.4mg/kg in mallard ducks, 7.94mg/kg in pheasants and 14mg/kg in chicken. Due to its toxicity, coumaphos is no longer available as a drug.
Approval Year
PubMed
Patents
Sample Use Guides
The recommended dose is 27.2 and 36,3 grams per ton of feed (0.003 and 0.004 percent) for laying chickens and replacement pullets, respectively. In cattles, coumaphos is given at a dose of 0.0002 pound (0.091 gram) per 100 pounds of body weight per day.
Route of Administration:
Oral
