Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H19ClN2O4 |
| Molecular Weight | 337.787 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[11CH3]N1CCC(COC(=O)C2=C3OC=COC3=C(N)C(Cl)=C2)CC1
InChI
InChIKey=KUTJZDOLWHPSLT-BJUDXGSMSA-N
InChI=1S/C16H19ClN2O4/c1-19-4-2-10(3-5-19)9-23-16(20)11-8-12(17)13(18)15-14(11)21-6-7-22-15/h6-8,10H,2-5,9,18H2,1H3/i1-1
| Molecular Formula | C16H19ClN2O4 |
| Molecular Weight | 337.787 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 18:53:33 GMT 2023
by
admin
on
Sat Dec 16 18:53:33 GMT 2023
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| Record UNII |
KZ4Z7737KU
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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1107064-22-1
Created by
admin on Sat Dec 16 18:53:33 GMT 2023 , Edited by admin on Sat Dec 16 18:53:33 GMT 2023
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KZ4Z7737KU
Created by
admin on Sat Dec 16 18:53:33 GMT 2023 , Edited by admin on Sat Dec 16 18:53:33 GMT 2023
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46913821
Created by
admin on Sat Dec 16 18:53:33 GMT 2023 , Edited by admin on Sat Dec 16 18:53:33 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
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NON-LABELED -> LABELED |
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TARGET->RADIOLIGAND |
IMAGING AGENT
Ki
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
A new selective radioligand, (11C)SB207145, for positron emission tomography (PET) was used to quantify brain 5-HT4 receptors in sixteen healthy subjects (2045 years, 8 males) using the simplified reference tissue model. Bmax was in accordance with post-mortem brain studies (Spearman's r = 0.83, p = 0.04), and the regional binding potentials, BPND, were on average 2.6 in striatum, 0.42 in prefrontal cortex, and 0.91 in hippocampus. We found no effect of sex but a decreased binding with age (p = 0.046). A power analysis showed that, given the low inter-and intrasubject variation, use of the present method will enable detection of a 15% difference in striatum with only 713 subjects in a 2-sample test and with only 45 subjects in a paired test.
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