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Details

Stereochemistry ACHIRAL
Molecular Formula C16H19ClN2O4
Molecular Weight 337.787
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SB-207145 C-11

SMILES

[11CH3]N1CCC(COC(=O)C2=C3OC=COC3=C(N)C(Cl)=C2)CC1

InChI

InChIKey=KUTJZDOLWHPSLT-BJUDXGSMSA-N
InChI=1S/C16H19ClN2O4/c1-19-4-2-10(3-5-19)9-23-16(20)11-8-12(17)13(18)15-14(11)21-6-7-22-15/h6-8,10H,2-5,9,18H2,1H3/i1-1

HIDE SMILES / InChI

Molecular Formula C16H19ClN2O4
Molecular Weight 337.787
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Substance Class Chemical
Created
by admin
on Sat Dec 16 18:53:33 UTC 2023
Edited
by admin
on Sat Dec 16 18:53:33 UTC 2023
Record UNII
KZ4Z7737KU
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SB-207145 C-11
Code English
(1-(METHYL-11C)-4-PIPERIDYL)METHYL 5-AMINO-6-CHLORO-1,4-BENZODIOXINE-8-CARBOXYLATE
Systematic Name English
11C-SB207145
Code English
1,4-BENZODIOXIN-5-CARBOXYLIC ACID, 8-AMINO-7-CHLORO-, (1-(METHYL-11C)-4-PIPERIDINYL)METHYL ESTER
Systematic Name English
(11C)SB-207145
Common Name English
11C-SB-207145
Code English
Code System Code Type Description
CAS
1107064-22-1
Created by admin on Sat Dec 16 18:53:33 UTC 2023 , Edited by admin on Sat Dec 16 18:53:33 UTC 2023
PRIMARY
FDA UNII
KZ4Z7737KU
Created by admin on Sat Dec 16 18:53:33 UTC 2023 , Edited by admin on Sat Dec 16 18:53:33 UTC 2023
PRIMARY
PUBCHEM
46913821
Created by admin on Sat Dec 16 18:53:33 UTC 2023 , Edited by admin on Sat Dec 16 18:53:33 UTC 2023
PRIMARY
Related Record Type Details
NON-LABELED -> LABELED
TARGET->RADIOLIGAND
IMAGING AGENT
Ki
Related Record Type Details
ACTIVE MOIETY
A new selective radioligand, (11C)SB207145, for positron emission tomography (PET) was used to quantify brain 5-HT4 receptors in sixteen healthy subjects (2045 years, 8 males) using the simplified reference tissue model. Bmax was in accordance with post-mortem brain studies (Spearman's r = 0.83, p = 0.04), and the regional binding potentials, BPND, were on average 2.6 in striatum, 0.42 in prefrontal cortex, and 0.91 in hippocampus. We found no effect of sex but a decreased binding with age (p = 0.046). A power analysis showed that, given the low inter-and intrasubject variation, use of the present method will enable detection of a 15% difference in striatum with only 713 subjects in a 2-sample test and with only 45 subjects in a paired test.