U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 19:29:10 GMT 2023
Edited
by admin
on Sat Dec 16 19:29:10 GMT 2023
Protein Type TETRASPECIFIC ANTIBODY
Protein Sub Type
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
KX8KZX98PB
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Umizortamig
INN  
Official Name English
scFv-G1-scFv-scFv fused heavy chain humanized and chimeric (1-1231)[scFv kappa-heavy anti-CD3E and CD3G humanized (1-252) [V-KAPPA (Homo sapiens IGKV1-5*01 (90.1%) -IGKJ4*01 (90.9%), CDR-IMGT[6.3.14] (27-32.50-52.89-102)) (1-112) -20-mer tetrakis(tetragl
Common Name English
umizortamig [INN]
Common Name English
Immunoglobulin, tetraspecific, anti-(human CD3 antigen ε-chain and γ-chain) (human-Oryctolagus cuniculus clone 284A10 single-chain variable fragment VL-(GGGGS)4-VH) fusion protein with peptide linker (GGGGS)2 fusion protein with immunoglobulin G1 anti-
Common Name English
immunoglobulin scFv-G1-scFv-scFv_L-kappa, anti-[Homo sapiens EGFRvIII (epidermal growth factor receptor (receptor tyrosine-protein kinase erbB-1, ERBB1, HER1, HER-1, ERBB) variant III)], anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4) and CD3G], anti-[Homo
Common Name English
Code System Code Type Description
CAS
2599198-83-9
Created by admin on Sat Dec 16 19:29:11 GMT 2023 , Edited by admin on Sat Dec 16 19:29:11 GMT 2023
PRIMARY
INN
12292
Created by admin on Sat Dec 16 19:29:11 GMT 2023 , Edited by admin on Sat Dec 16 19:29:11 GMT 2023
PRIMARY
FDA UNII
KX8KZX98PB
Created by admin on Sat Dec 16 19:29:11 GMT 2023 , Edited by admin on Sat Dec 16 19:29:11 GMT 2023
PRIMARY
From To
1_487 2_487
1_490 2_490
2_481 4_214
1_481 3_214
4_134 4_194
4_23 4_88
3_134 3_194
3_23 3_88
1_1142 1_1207
2_1142 2_1207
1_1000 1_1076
2_1000 2_1076
1_882 1_947
2_882 2_947
1_739 1_815
2_739 2_815
1_628 1_686
2_628 2_686
1_522 1_582
2_522 2_582
1_405 1_461
2_405 2_461
1_284 1_358
2_284 2_358
1_154 1_227
2_154 2_227
1_23 1_88
2_23 2_88
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_558
N 2_558
Related Record Type Details
TARGET->LIGAND
TARGET->LIGAND
TARGET -> ACTIVATOR
TARGET->LIGAND
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL