ABELACIMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 23:16:47 GMT 2025` Edited by `admin` on `Tue Apr 01 23:16:47 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	KX1N4TV7UY
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ABELACIMAB

Official Name

English

Abelacimab [WHO-DD]

Preferred Name

English

IMMUNOGLOBULIN G1, ANTI-(HUMAN BLOOD-COAGULATION FACTOR XI) (HUMAN MONOCLONAL CLONE NVS250519 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL NVS250519 .LAMBDA.-CHAIN, DIMER

Common Name

English

abelacimab [INN]

Common Name

English

Code System Code Type Description

INN

10881

Created by admin on Tue Apr 01 23:16:47 GMT 2025 , Edited by admin on Tue Apr 01 23:16:47 GMT 2025

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CAS

2098724-83-3

Created by admin on Tue Apr 01 23:16:47 GMT 2025 , Edited by admin on Tue Apr 01 23:16:47 GMT 2025

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SMS_ID

100000183551

Created by admin on Tue Apr 01 23:16:47 GMT 2025 , Edited by admin on Tue Apr 01 23:16:47 GMT 2025

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FDA UNII

KX1N4TV7UY

Created by admin on Tue Apr 01 23:16:47 GMT 2025 , Edited by admin on Tue Apr 01 23:16:47 GMT 2025

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NCI_THESAURUS

C169755

Created by admin on Tue Apr 01 23:16:47 GMT 2025 , Edited by admin on Tue Apr 01 23:16:47 GMT 2025

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From	To
1_22	1_96
1_149	1_205
1_266	1_326
1_372	1_430
2_22	2_96
2_149	2_205
2_266	2_326
2_372	2_430
1_225	3_215
2_225	4_215
1_231	2_231
1_234	2_234
3_22	3_89
3_138	3_197
4_22	4_89
4_138	4_197

Related Record Type Details


					KX1N4TV7UY

ACTIVE MOIETY

Comments:

immunomodulatory, blood coagulation factor inhibitor

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1] [3_1] [4_1]	SITE_SPECIFIC			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL