Details
Stereochemistry | ACHIRAL |
Molecular Formula | C7H8N2 |
Molecular Weight | 120.1518 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
NC(=N)C1=CC=CC=C1
InChI
InChIKey=PXXJHWLDUBFPOL-UHFFFAOYSA-N
InChI=1S/C7H8N2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H3,8,9)
Molecular Formula | C7H8N2 |
Molecular Weight | 120.1518 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Pattern recognition and massively distributed computing. | 2002 Dec |
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The effect of Puerariae radix on lipoprotein metabolism in liver and intestinal cells. | 2002 Dec 16 |
|
Inhibition of arginine gingipains (RgpB and HRgpA) with benzamidine inhibitors: zinc increases inhibitory potency. | 2002 Jul-Aug |
|
[Purification and characterization of the fibrinolytic enzyme from Agkistrodon halys halys venom]. | 2002 May-Jun |
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Identification, characterization, and cloning of an immunoglobulin degrading enzyme in the cat flea, Ctenocephalides felis. | 2002 Nov |
|
Thrombin inhibition by novel benzamidine derivatives: a free-energy perturbation study. | 2002 Nov 7 |
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The PEST sequence does not contribute to the stability of the cystic fibrosis transmembrane conductance regulator. | 2002 Oct 2 |
|
Mutant K-ras oncogene regulates steroidogenesis of normal human adrenocortical cells by the RAF-MEK-MAPK pathway. | 2002 Oct 21 |
|
Aggregation and retention of human urokinase type plasminogen activator in the yeast endoplasmic reticulum. | 2002 Oct 7 |
|
Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: mechanism of cell death. | 2002 Sep 23 |
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Inhibitors of benzamidine type influence the virulence properties of Porphyromonas gingivalis strains. | 2003 |
|
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. | 2003 |
|
Purification, properties and substrate specificity of a digestive trypsin from Periplaneta americana (Dictyoptera) adults. | 2003 Apr |
|
A role for BRCA1 in sporadic breast cancer. | 2003 Apr 22 |
|
Identification and partial characterization of two inducible gelatin-cleavage activities localized to the sea urchin extraembryonic matrix, the hyaline layer. | 2003 Apr 7 |
|
Steroid-induced polycystic ovaries in rats: effect of electro-acupuncture on concentrations of endothelin-1 and nerve growth factor (NGF), and expression of NGF mRNA in the ovaries, the adrenal glands, and the central nervous system. | 2003 Apr 8 |
|
Efficacious and orally bioavailable thrombin inhibitors based on a 2,5-thienylamidine at the P1 position: discovery of N-carboxymethyl-d-diphenylalanyl-l-prolyl[(5-amidino-2-thienyl)methyl]amide. | 2003 Aug 14 |
|
Engineering the primary substrate specificity of Streptomyces griseus trypsin. | 2003 Aug 5 |
|
Design and synthesis of highly constrained factor Xa inhibitors: amidine-substituted bis(benzoyl)--diazepan-2-ones and bis(benzylidene)-bis(gem-dimethyl)cycloketones. | 2003 Aug 5 |
|
Novel oxidative alpha-tosyloxylation of alcohols with iodosylbenzene and p-toluenesulfonic acid and its synthetic use for direct preparation of heteroaromatics. | 2003 Aug 8 |
|
Characterization of a trypsin-like serine protease of activated B cells mediating the cleavage of surface proteins. | 2003 Dec 5 |
|
A novel influenza A virus activating enzyme from porcine lung: purification and characterization. | 2003 Feb |
|
Effect of CD26/dipeptidyl peptidase IV on Jurkat sensitivity to G2/M arrest induced by topoisomerase II inhibitors. | 2003 Feb 10 |
|
Nonbenzamidine tetrazole derivatives as factor Xa inhibitors. | 2003 Feb 10 |
|
Molecular structures of human factor Xa complexed with ketopiperazine inhibitors: preference for a neutral group in the S1 pocket. | 2003 Feb 27 |
|
Purification and partial characterization of feline classical pancreatic lipase. | 2003 Jan |
|
Disruption of vitellogenin gene function in adult honeybees by intra-abdominal injection of double-stranded RNA. | 2003 Jan 20 |
|
Reconstructing the binding site of factor Xa in trypsin reveals ligand-induced structural plasticity. | 2003 Jan 31 |
|
Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas. | 2003 Jan 31 |
|
Inhibition of purified factor Xa amidolytic activity may not be predictive of inhibition of in vivo thrombosis: implications for identification of therapeutically active inhibitors. | 2003 Jun 1 |
|
Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro. | 2003 Jun 16 |
|
Characterisation of integrin-linked kinase signalling in sporadic human colon cancer. | 2003 Jun 2 |
|
Nonbenzamidine isoxazoline derivatives as factor Xa inhibitors. | 2003 Mar 24 |
|
Discovery of 3-amino-4-chlorophenyl P1 as a novel and potent benzamidine mimic via solid-phase synthesis of an isoxazoline library. | 2003 May 19 |
|
Rational design, synthesis, and structure-activity relationships of novel factor Xa inhibitors: (2-substituted-4-amidinophenyl)pyruvic and -propionic acids. | 2003 May 8 |
|
[Preparation of high-purity and safe autologous plasmin and its clinical application]. | 2003 Nov |
|
Multinuclear magnetic resonance and theoretical calculations in the study of structure and tautomerism of some 2-amino-N'-(aryl)-benzamidines. | 2003 Nov |
|
Synthesis of L-ascorbic acid in the phloem. | 2003 Nov 24 |
|
Type III secretion proteins PcrV and PcrG from Pseudomonas aeruginosa form a 1:1 complex through high affinity interactions. | 2003 Oct 18 |
|
CD26/dipeptidyl peptidase IV enhances expression of topoisomerase II alpha and sensitivity to apoptosis induced by topoisomerase II inhibitors. | 2003 Oct 6 |
|
Structure-based design of novel guanidine/benzamidine mimics: potent and orally bioavailable factor Xa inhibitors as novel anticoagulants. | 2003 Oct 9 |
|
Cloning and characterization of a transmembrane-type serine protease from rat kidney, a new sodium channel activator. | 2003 Oct-Nov |
|
Modulation of enzymatic activity of human mast cell tryptase and chymase by protease inhibitors. | 2003 Sep |
|
Molecular cloning of trypsin-like cDNAs and comparison of proteinase activities in the salivary glands and gut of the tarnished plant bug Lygus lineolaris (Heteroptera: Miridae). | 2003 Sep |
|
Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis. | 2003 Sep 1 |
|
Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization. | 2004 Apr 2 |
|
Site-directed mutagenesis at the human B2 receptor and molecular modelling to define the pharmacophore of non-peptide bradykinin receptor antagonists. | 2004 Feb 15 |
|
Protein interaction networks by proteome peptide scanning. | 2004 Jan |
|
Understanding protein-ligand interactions: the price of protein flexibility. | 2004 Jan 30 |
|
Collagen degradation by host-derived enzymes during aging. | 2004 Mar |
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 17 00:14:06 UTC 2022
by
admin
on
Sat Dec 17 00:14:06 UTC 2022
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Record UNII |
KUE3ZY3J1F
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Record Status |
Validated (UNII)
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Record Version |
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DTXSID8045012
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618-39-3
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KUE3ZY3J1F
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DB03127
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210-546-3
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41033
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243704
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BENZAMIDINE
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2332
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C032157
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Related Record | Type | Details | ||
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TARGET -> INHIBITOR |
ANTAGONIST
Kb
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SALT/SOLVATE -> PARENT |
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TARGET -> INHIBITOR |
BINDING
Ki
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Related Record | Type | Details | ||
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PARENT -> METABOLITE INACTIVE |