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Details

Stereochemistry ACHIRAL
Molecular Formula C7H8N2
Molecular Weight 120.1518
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BENZAMIDINE

SMILES

NC(=N)C1=CC=CC=C1

InChI

InChIKey=PXXJHWLDUBFPOL-UHFFFAOYSA-N
InChI=1S/C7H8N2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H3,8,9)

HIDE SMILES / InChI

Molecular Formula C7H8N2
Molecular Weight 120.1518
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Pattern recognition and massively distributed computing.
2002 Dec
The effect of Puerariae radix on lipoprotein metabolism in liver and intestinal cells.
2002 Dec 16
Inhibition of arginine gingipains (RgpB and HRgpA) with benzamidine inhibitors: zinc increases inhibitory potency.
2002 Jul-Aug
[Purification and characterization of the fibrinolytic enzyme from Agkistrodon halys halys venom].
2002 May-Jun
Identification, characterization, and cloning of an immunoglobulin degrading enzyme in the cat flea, Ctenocephalides felis.
2002 Nov
Thrombin inhibition by novel benzamidine derivatives: a free-energy perturbation study.
2002 Nov 7
The PEST sequence does not contribute to the stability of the cystic fibrosis transmembrane conductance regulator.
2002 Oct 2
Mutant K-ras oncogene regulates steroidogenesis of normal human adrenocortical cells by the RAF-MEK-MAPK pathway.
2002 Oct 21
Aggregation and retention of human urokinase type plasminogen activator in the yeast endoplasmic reticulum.
2002 Oct 7
Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: mechanism of cell death.
2002 Sep 23
Inhibitors of benzamidine type influence the virulence properties of Porphyromonas gingivalis strains.
2003
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.
2003
Purification, properties and substrate specificity of a digestive trypsin from Periplaneta americana (Dictyoptera) adults.
2003 Apr
A role for BRCA1 in sporadic breast cancer.
2003 Apr 22
Identification and partial characterization of two inducible gelatin-cleavage activities localized to the sea urchin extraembryonic matrix, the hyaline layer.
2003 Apr 7
Steroid-induced polycystic ovaries in rats: effect of electro-acupuncture on concentrations of endothelin-1 and nerve growth factor (NGF), and expression of NGF mRNA in the ovaries, the adrenal glands, and the central nervous system.
2003 Apr 8
Efficacious and orally bioavailable thrombin inhibitors based on a 2,5-thienylamidine at the P1 position: discovery of N-carboxymethyl-d-diphenylalanyl-l-prolyl[(5-amidino-2-thienyl)methyl]amide.
2003 Aug 14
Engineering the primary substrate specificity of Streptomyces griseus trypsin.
2003 Aug 5
Design and synthesis of highly constrained factor Xa inhibitors: amidine-substituted bis(benzoyl)--diazepan-2-ones and bis(benzylidene)-bis(gem-dimethyl)cycloketones.
2003 Aug 5
Novel oxidative alpha-tosyloxylation of alcohols with iodosylbenzene and p-toluenesulfonic acid and its synthetic use for direct preparation of heteroaromatics.
2003 Aug 8
Characterization of a trypsin-like serine protease of activated B cells mediating the cleavage of surface proteins.
2003 Dec 5
A novel influenza A virus activating enzyme from porcine lung: purification and characterization.
2003 Feb
Effect of CD26/dipeptidyl peptidase IV on Jurkat sensitivity to G2/M arrest induced by topoisomerase II inhibitors.
2003 Feb 10
Nonbenzamidine tetrazole derivatives as factor Xa inhibitors.
2003 Feb 10
Molecular structures of human factor Xa complexed with ketopiperazine inhibitors: preference for a neutral group in the S1 pocket.
2003 Feb 27
Purification and partial characterization of feline classical pancreatic lipase.
2003 Jan
Disruption of vitellogenin gene function in adult honeybees by intra-abdominal injection of double-stranded RNA.
2003 Jan 20
Reconstructing the binding site of factor Xa in trypsin reveals ligand-induced structural plasticity.
2003 Jan 31
Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas.
2003 Jan 31
Inhibition of purified factor Xa amidolytic activity may not be predictive of inhibition of in vivo thrombosis: implications for identification of therapeutically active inhibitors.
2003 Jun 1
Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro.
2003 Jun 16
Characterisation of integrin-linked kinase signalling in sporadic human colon cancer.
2003 Jun 2
Nonbenzamidine isoxazoline derivatives as factor Xa inhibitors.
2003 Mar 24
Discovery of 3-amino-4-chlorophenyl P1 as a novel and potent benzamidine mimic via solid-phase synthesis of an isoxazoline library.
2003 May 19
Rational design, synthesis, and structure-activity relationships of novel factor Xa inhibitors: (2-substituted-4-amidinophenyl)pyruvic and -propionic acids.
2003 May 8
[Preparation of high-purity and safe autologous plasmin and its clinical application].
2003 Nov
Multinuclear magnetic resonance and theoretical calculations in the study of structure and tautomerism of some 2-amino-N'-(aryl)-benzamidines.
2003 Nov
Synthesis of L-ascorbic acid in the phloem.
2003 Nov 24
Type III secretion proteins PcrV and PcrG from Pseudomonas aeruginosa form a 1:1 complex through high affinity interactions.
2003 Oct 18
CD26/dipeptidyl peptidase IV enhances expression of topoisomerase II alpha and sensitivity to apoptosis induced by topoisomerase II inhibitors.
2003 Oct 6
Structure-based design of novel guanidine/benzamidine mimics: potent and orally bioavailable factor Xa inhibitors as novel anticoagulants.
2003 Oct 9
Cloning and characterization of a transmembrane-type serine protease from rat kidney, a new sodium channel activator.
2003 Oct-Nov
Modulation of enzymatic activity of human mast cell tryptase and chymase by protease inhibitors.
2003 Sep
Molecular cloning of trypsin-like cDNAs and comparison of proteinase activities in the salivary glands and gut of the tarnished plant bug Lygus lineolaris (Heteroptera: Miridae).
2003 Sep
Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis.
2003 Sep 1
Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization.
2004 Apr 2
Site-directed mutagenesis at the human B2 receptor and molecular modelling to define the pharmacophore of non-peptide bradykinin receptor antagonists.
2004 Feb 15
Protein interaction networks by proteome peptide scanning.
2004 Jan
Understanding protein-ligand interactions: the price of protein flexibility.
2004 Jan 30
Collagen degradation by host-derived enzymes during aging.
2004 Mar
Patents
Substance Class Chemical
Created
by admin
on Sat Dec 17 00:14:06 UTC 2022
Edited
by admin
on Sat Dec 17 00:14:06 UTC 2022
Record UNII
KUE3ZY3J1F
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BENZAMIDINE
Systematic Name English
NSC-243704
Code English
BENZENECARBOXIMIDAMIDE
Systematic Name English
Code System Code Type Description
EPA CompTox
DTXSID8045012
Created by admin on Sat Dec 17 00:14:06 UTC 2022 , Edited by admin on Sat Dec 17 00:14:06 UTC 2022
PRIMARY
CAS
618-39-3
Created by admin on Sat Dec 17 00:14:06 UTC 2022 , Edited by admin on Sat Dec 17 00:14:06 UTC 2022
PRIMARY
FDA UNII
KUE3ZY3J1F
Created by admin on Sat Dec 17 00:14:06 UTC 2022 , Edited by admin on Sat Dec 17 00:14:06 UTC 2022
PRIMARY
DRUG BANK
DB03127
Created by admin on Sat Dec 17 00:14:06 UTC 2022 , Edited by admin on Sat Dec 17 00:14:06 UTC 2022
PRIMARY
ECHA (EC/EINECS)
210-546-3
Created by admin on Sat Dec 17 00:14:06 UTC 2022 , Edited by admin on Sat Dec 17 00:14:06 UTC 2022
PRIMARY
CHEBI
41033
Created by admin on Sat Dec 17 00:14:06 UTC 2022 , Edited by admin on Sat Dec 17 00:14:06 UTC 2022
PRIMARY
NSC
243704
Created by admin on Sat Dec 17 00:14:06 UTC 2022 , Edited by admin on Sat Dec 17 00:14:06 UTC 2022
PRIMARY
WIKIPEDIA
BENZAMIDINE
Created by admin on Sat Dec 17 00:14:06 UTC 2022 , Edited by admin on Sat Dec 17 00:14:06 UTC 2022
PRIMARY
PUBCHEM
2332
Created by admin on Sat Dec 17 00:14:06 UTC 2022 , Edited by admin on Sat Dec 17 00:14:06 UTC 2022
PRIMARY
MESH
C032157
Created by admin on Sat Dec 17 00:14:06 UTC 2022 , Edited by admin on Sat Dec 17 00:14:06 UTC 2022
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
ANTAGONIST
Kb
SALT/SOLVATE -> PARENT
TARGET -> INHIBITOR
BINDING
Ki
Related Record Type Details
PARENT -> METABOLITE INACTIVE