BENZAMIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H8N2
Molecular Weight	120.1518
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=N)C1=CC=CC=C1

InChI

InChIKey=PXXJHWLDUBFPOL-UHFFFAOYSA-N

InChI=1S/C7H8N2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H3,8,9)

HIDE SMILES / InChI

Molecular Formula	C7H8N2
Molecular Weight	120.1518
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Pattern recognition and massively distributed computing.	2002 Dec	12395423
The effect of Puerariae radix on lipoprotein metabolism in liver and intestinal cells.	2002 Dec 16	12485466
Inhibition of arginine gingipains (RgpB and HRgpA) with benzamidine inhibitors: zinc increases inhibitory potency.	2002 Jul-Aug	12437105
[Purification and characterization of the fibrinolytic enzyme from Agkistrodon halys halys venom].	2002 May-Jun	12916236
Identification, characterization, and cloning of an immunoglobulin degrading enzyme in the cat flea, Ctenocephalides felis.	2002 Nov	12386841
Thrombin inhibition by novel benzamidine derivatives: a free-energy perturbation study.	2002 Nov 7	12408710
The PEST sequence does not contribute to the stability of the cystic fibrosis transmembrane conductance regulator.	2002 Oct 2	12361483
Mutant K-ras oncogene regulates steroidogenesis of normal human adrenocortical cells by the RAF-MEK-MAPK pathway.	2002 Oct 21	12434292
Aggregation and retention of human urokinase type plasminogen activator in the yeast endoplasmic reticulum.	2002 Oct 7	12366865
Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: mechanism of cell death.	2002 Sep 23	12232767
Inhibitors of benzamidine type influence the virulence properties of Porphyromonas gingivalis strains.	2003	14515152
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.	2003	14511394
Purification, properties and substrate specificity of a digestive trypsin from Periplaneta americana (Dictyoptera) adults.	2003 Apr	12650689
A role for BRCA1 in sporadic breast cancer.	2003 Apr 22	12698194
Identification and partial characterization of two inducible gelatin-cleavage activities localized to the sea urchin extraembryonic matrix, the hyaline layer.	2003 Apr 7	12667612
Steroid-induced polycystic ovaries in rats: effect of electro-acupuncture on concentrations of endothelin-1 and nerve growth factor (NGF), and expression of NGF mRNA in the ovaries, the adrenal glands, and the central nervous system.	2003 Apr 8	12725645
Efficacious and orally bioavailable thrombin inhibitors based on a 2,5-thienylamidine at the P1 position: discovery of N-carboxymethyl-d-diphenylalanyl-l-prolyl[(5-amidino-2-thienyl)methyl]amide.	2003 Aug 14	12904065
Engineering the primary substrate specificity of Streptomyces griseus trypsin.	2003 Aug 5	12885239
Design and synthesis of highly constrained factor Xa inhibitors: amidine-substituted bis(benzoyl)--diazepan-2-ones and bis(benzylidene)-bis(gem-dimethyl)cycloketones.	2003 Aug 5	12878132
Novel oxidative alpha-tosyloxylation of alcohols with iodosylbenzene and p-toluenesulfonic acid and its synthetic use for direct preparation of heteroaromatics.	2003 Aug 8	12895080
Characterization of a trypsin-like serine protease of activated B cells mediating the cleavage of surface proteins.	2003 Dec 5	14642814
A novel influenza A virus activating enzyme from porcine lung: purification and characterization.	2003 Feb	12675514
Effect of CD26/dipeptidyl peptidase IV on Jurkat sensitivity to G2/M arrest induced by topoisomerase II inhibitors.	2003 Feb 10	12569391
Nonbenzamidine tetrazole derivatives as factor Xa inhibitors.	2003 Feb 10	12565931
Molecular structures of human factor Xa complexed with ketopiperazine inhibitors: preference for a neutral group in the S1 pocket.	2003 Feb 27	12593649
Purification and partial characterization of feline classical pancreatic lipase.	2003 Jan	12524043
Disruption of vitellogenin gene function in adult honeybees by intra-abdominal injection of double-stranded RNA.	2003 Jan 20	12546706
Reconstructing the binding site of factor Xa in trypsin reveals ligand-induced structural plasticity.	2003 Jan 31	12527302
Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas.	2003 Jan 31	12441343
Inhibition of purified factor Xa amidolytic activity may not be predictive of inhibition of in vivo thrombosis: implications for identification of therapeutically active inhibitors.	2003 Jun 1	12750119
Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro.	2003 Jun 16	12799645
Characterisation of integrin-linked kinase signalling in sporadic human colon cancer.	2003 Jun 2	12771992
Nonbenzamidine isoxazoline derivatives as factor Xa inhibitors.	2003 Mar 24	12643903
Discovery of 3-amino-4-chlorophenyl P1 as a novel and potent benzamidine mimic via solid-phase synthesis of an isoxazoline library.	2003 May 19	12729667
Rational design, synthesis, and structure-activity relationships of novel factor Xa inhibitors: (2-substituted-4-amidinophenyl)pyruvic and -propionic acids.	2003 May 8	12723948
[Preparation of high-purity and safe autologous plasmin and its clinical application].	2003 Nov	14661545
Multinuclear magnetic resonance and theoretical calculations in the study of structure and tautomerism of some 2-amino-N'-(aryl)-benzamidines.	2003 Nov	14583289
Synthesis of L-ascorbic acid in the phloem.	2003 Nov 24	14633288
Type III secretion proteins PcrV and PcrG from Pseudomonas aeruginosa form a 1:1 complex through high affinity interactions.	2003 Oct 18	14565848
CD26/dipeptidyl peptidase IV enhances expression of topoisomerase II alpha and sensitivity to apoptosis induced by topoisomerase II inhibitors.	2003 Oct 6	14520473
Structure-based design of novel guanidine/benzamidine mimics: potent and orally bioavailable factor Xa inhibitors as novel anticoagulants.	2003 Oct 9	14521405
Cloning and characterization of a transmembrane-type serine protease from rat kidney, a new sodium channel activator.	2003 Oct-Nov	14669991
Modulation of enzymatic activity of human mast cell tryptase and chymase by protease inhibitors.	2003 Sep	12956943
Molecular cloning of trypsin-like cDNAs and comparison of proteinase activities in the salivary glands and gut of the tarnished plant bug Lygus lineolaris (Heteroptera: Miridae).	2003 Sep	12915180
Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis.	2003 Sep 1	12942121
Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization.	2004 Apr 2	14726520
Site-directed mutagenesis at the human B2 receptor and molecular modelling to define the pharmacophore of non-peptide bradykinin receptor antagonists.	2004 Feb 15	14757160
Protein interaction networks by proteome peptide scanning.	2004 Jan	14737190
Understanding protein-ligand interactions: the price of protein flexibility.	2004 Jan 30	14729347
Collagen degradation by host-derived enzymes during aging.	2004 Mar	14981122

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 17 00:14:06 UTC 2022` Edited by `admin` on `Sat Dec 17 00:14:06 UTC 2022`
Record UNII	KUE3ZY3J1F
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BENZAMIDINE

Systematic Name

English

NSC-243704

Code

English

BENZENECARBOXIMIDAMIDE

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID8045012