Imzokitug

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NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 10:50:35 GMT 2025` Edited by `admin` on `Wed Apr 02 10:50:35 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	KS4YMP5WRH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Imzokitug

Official Name

English

BMS-986340

Preferred Name

English

Immunoglobulin G1 [de-C-terminal-lysine], anti-(human CC chemokine receptor CCR8) (human-Mus musculus monoclonal BMS-986340 ?1-chain), disulfide with human-Mus musculus monoclonal BMS-986340 ?-chain, dimer

Common Name

English

Immunoglobulin G1 [de-C-terminal lysine], anti-(human chemokine receptor 8 CCR8) (human monoclonal CCR8.50-g1f ?1-chain), disulfide with human monoclonal CCR8.50-g1f .kappa.-chain, dimer gamma1 heavy chain Homo sapiens (1-445) [VH (Homo sapiens IGHV1-2*0

Common Name

English

IMZOKITUG [USAN]

Common Name

English

BMS986340

Code

English

CCR8.50

Code

English

Code System Code Type Description

SMS_ID

300000033958

Created by admin on Wed Apr 02 10:50:35 GMT 2025 , Edited by admin on Wed Apr 02 10:50:35 GMT 2025

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NCI_THESAURUS

C179913

Created by admin on Wed Apr 02 10:50:35 GMT 2025 , Edited by admin on Wed Apr 02 10:50:35 GMT 2025

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CAS

2883771-61-5

Created by admin on Wed Apr 02 10:50:35 GMT 2025 , Edited by admin on Wed Apr 02 10:50:35 GMT 2025

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USAN

LM-186

Created by admin on Wed Apr 02 10:50:35 GMT 2025 , Edited by admin on Wed Apr 02 10:50:35 GMT 2025

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FDA UNII

KS4YMP5WRH

Created by admin on Wed Apr 02 10:50:35 GMT 2025 , Edited by admin on Wed Apr 02 10:50:35 GMT 2025

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INN

13223

Created by admin on Wed Apr 02 10:50:35 GMT 2025 , Edited by admin on Wed Apr 02 10:50:35 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_143	2_199
2_219	4_219
2_260	2_320
1_143	1_199
2_366	2_424
3_23	3_93
3_139	3_199
4_23	4_93
4_139	4_199
1_219	3_219
1_225	2_225
1_228	2_228
1_260	1_320
1_366	1_424

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_296
N	2_296

Related Record Type Details


					7T1P6UJ4LY

C-C CHEMOKINE RECEPTOR TYPE 8

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					KS4YMP5WRH

Imzokitug

ACTIVE MOIETY

Comments:

BMS-986340 is an anti-CCR8 mAb that blocks CCR8 interaction with its ligand CCL1. Binding of BMS-986340 to CCR8 results in antibody-dependent, cellular cytotoxicity-mediated depletion of Tregs in the TME, and thereby is expected to lead to effector T cell activation and anti-tumor immunity.

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL