Vamikibart

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 00:24:19 GMT 2025` Edited by `admin` on `Wed Apr 02 00:24:19 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG2\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	KP04MH1JTT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Vamikibart

Official Name

English

EBI-031

Preferred Name

English

vamikibart [INN]

Common Name

English

RECOMBINANT HUMANISED IGG2 KAPPA ANTI-INTERLEUKIN 6 MONOCLONAL ANTIBODY RO7200220

Common Name

English

EBI031

Code

English

VAMIKIBART [USAN]

Common Name

English

RO-7200220

Code

English

Immunoglobulin G2 [311-alanine], anti-(human interleukin 6) (human monoclonal RG6179 ?2-chain), disulfide with human monoclonal RG6179 ?-chain, dimer

Common Name

English

RG6179

Code

English

RG-6179

Code

English

immunoglobulin G2-kappa, anti-[Homo sapiens IL6 (interleukin 6)], humanized and chimeric monoclonal antibody; gamma2 heavy chain humanized (1-448) [VH ( Homo sapiens IGHV1-69*11 (86.7%) -(IGHD) -IGHJ5*02 (90.9%) L123>T (117), CDR-IMGT [8.8.15] (26-33.51-

Common Name

English

Vamikibart [WHO-DD]

Common Name

English

RO7200220

Code

English

Code System Code Type Description

SMS_ID

300000037299

Created by admin on Wed Apr 02 00:24:20 GMT 2025 , Edited by admin on Wed Apr 02 00:24:20 GMT 2025

PRIMARY

USAN

MN-114

Created by admin on Wed Apr 02 00:24:20 GMT 2025 , Edited by admin on Wed Apr 02 00:24:20 GMT 2025

PRIMARY

FDA UNII

KP04MH1JTT

Created by admin on Wed Apr 02 00:24:20 GMT 2025 , Edited by admin on Wed Apr 02 00:24:20 GMT 2025

PRIMARY

CAS

2744320-12-3

Created by admin on Wed Apr 02 00:24:20 GMT 2025 , Edited by admin on Wed Apr 02 00:24:20 GMT 2025

PRIMARY

INN

12560

Created by admin on Wed Apr 02 00:24:20 GMT 2025 , Edited by admin on Wed Apr 02 00:24:20 GMT 2025

PRIMARY

NCI_THESAURUS

C199126

Created by admin on Wed Apr 02 00:24:20 GMT 2025 , Edited by admin on Wed Apr 02 00:24:20 GMT 2025

PRIMARY

From	To
1_22	1_96
1_368	1_426
2_22	2_96
2_136	4_218
2_149	2_205
1_136	3_218
2_262	2_322
2_368	2_426
3_23	3_92
3_138	3_198
1_149	1_205
4_23	4_92
4_138	4_198
1_224	2_224
1_225	2_225
1_228	2_228
1_231	2_231
1_262	1_322

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_298
N	2_298

Related Record Type Details


					4O4QWG0B3C

HUMAN INTERLEUKIN-6

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					KP04MH1JTT

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_448] [2_448]	C-TERMINUS			LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL