DIFETHIALONE

Description
Sources: http://www.garrards.com.au/images/stories/zone_files/labels/rodilon_professional_rodenticide_label.pdf
Curator's Comment: Description was created based on several sources, including http://icm-eg.com/AgriculturalSector/PDF/DIFETHIALONE%20Wheat.pdf and http://sitem.herts.ac.uk/aeru/iupac/Reports/233.htm

Difethialone is an anticoagulant used as a rodenticide. Difethialone is not approved for use in Europe but is still used elsewhere. It is relatively volatile, has low potential to leach to groundwater but is highly persistent in soils. It is highly toxic to humans and considered to produce adverse effects on the reproduction system. In May 2008, the United States Environmental Protection Agency banned the use of difethialone in consumer-use rodenticide products and also for exterior use by commercial applicators.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Response of predominant rodent borne diseases to difethialone anticoagulant rodenticide under laboratory conditions.	2010-12	21268533
Analysis of multiple anticoagulant rodenticides in animal blood and liver tissue using principles of QuEChERS method.	2010-06	20529461
Validation of a new liquid chromatography- tandem mass spectrometry ion-trap technique for the simultaneous determination of thirteen anticoagulant rodenticides, drugs, or natural products.	2010-03	20223102
Anticoagulant rodenticides in three owl species from Western Canada, 1988-2003.	2010-02	19826750
Consequences of the Y139F Vkorc1 mutation on resistance to AVKs: in-vivo investigation in a 7th generation of congenic Y139F strain of rats.	2009-10	19752778
Simultaneous bleeding and thrombosis in superwarfarin poisoning.	2009-02	18372007
Pharmacokinetics of eight anticoagulant rodenticides in mice after single oral administration.	2008-10	19000263
Intoxication with three different superwarfarin compounds in an adult woman.	2008-07	18612553
Multi-residue analysis of eight anticoagulant rodenticides in animal plasma and liver using liquid chromatography combined with heated electrospray ionization tandem mass spectrometry.	2008-06-15	18502701
Acute bromadiolone intoxication.	2006-05	16803669
Evaluation of secondary poisoning of difethialone, a new second-generation anticoagulant rodenticide to barn owl, Tyto alba Hartert under captivity.	2004-10	15511007
Effect of supplementary feeding of vitamin K1 on difethialone treated Indian gerbil, Tatera indica Hardwicke in laboratory.	2004-03	15233301
Field evaluation of difethialone, a new second generation anticoagulant rodenticide in the rice fields.	2003-06	15266918
A scheme for the placement of rodenticide baits for rat eradication on confinement livestock farms.	2003-05-15	12706053
[Plague control in Madagascar: evaluation of the efficacy of Kartman baitboxes in urban areas].	2003	15678815

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Mixture Created by `admin` on `Mon Mar 31 21:33:49 GMT 2025` Edited by `admin` on `Mon Mar 31 21:33:49 GMT 2025`
Record UNII	KOL4VXI5O0
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DIFETHIALONE

Common Name

English

DIFETHIAROL

Preferred Name

English

DIFETHIAROL [JAN]

Common Name

English

LM-2219

Code

English

BARAKI

Brand Name

English

2H-1-BENZOTHIOPYRAN-2-ONE, 3-(3-(4'-BROMO(1,1'-BIPHENYL)-4-YL)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL)-4-HYDROXY-

Common Name

English

DIFETHIALONE [MI]

Common Name

English

DIFETHIALONE [ISO]

Code

English

LM 2219

Code

English

Classification Tree Code System Code

EPA PESTICIDE CODE

128967