DescriptionCurator's Comment: Description was created based on several sources, including
http://icm-eg.com/AgriculturalSector/PDF/DIFETHIALONE%20Wheat.pdf and
http://sitem.herts.ac.uk/aeru/iupac/Reports/233.htm
Curator's Comment: Description was created based on several sources, including
http://icm-eg.com/AgriculturalSector/PDF/DIFETHIALONE%20Wheat.pdf and
http://sitem.herts.ac.uk/aeru/iupac/Reports/233.htm
Difethialone is an anticoagulant used as a rodenticide. Difethialone is not approved for use in Europe but is still used elsewhere. It is relatively volatile, has low potential to leach to groundwater but is highly persistent in soils. It is highly toxic to humans and considered to produce adverse effects on the reproduction system. In May 2008, the United States Environmental Protection Agency banned the use of difethialone in consumer-use rodenticide products and also for exterior use by commercial applicators.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Plague control in Madagascar: evaluation of the efficacy of Kartman baitboxes in urban areas]. | 2003 |
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| Field evaluation of difethialone, a new second generation anticoagulant rodenticide in the rice fields. | 2003 Jun |
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| A scheme for the placement of rodenticide baits for rat eradication on confinement livestock farms. | 2003 May 15 |
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| Effect of supplementary feeding of vitamin K1 on difethialone treated Indian gerbil, Tatera indica Hardwicke in laboratory. | 2004 Mar |
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| Evaluation of secondary poisoning of difethialone, a new second-generation anticoagulant rodenticide to barn owl, Tyto alba Hartert under captivity. | 2004 Oct |
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| Acute bromadiolone intoxication. | 2006 May |
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| Intoxication with three different superwarfarin compounds in an adult woman. | 2008 Jul |
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| Multi-residue analysis of eight anticoagulant rodenticides in animal plasma and liver using liquid chromatography combined with heated electrospray ionization tandem mass spectrometry. | 2008 Jun 15 |
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| Pharmacokinetics of eight anticoagulant rodenticides in mice after single oral administration. | 2008 Oct |
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| Simultaneous bleeding and thrombosis in superwarfarin poisoning. | 2009 Feb |
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| Consequences of the Y139F Vkorc1 mutation on resistance to AVKs: in-vivo investigation in a 7th generation of congenic Y139F strain of rats. | 2009 Oct |
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| Response of predominant rodent borne diseases to difethialone anticoagulant rodenticide under laboratory conditions. | 2010 Dec |
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| Anticoagulant rodenticides in three owl species from Western Canada, 1988-2003. | 2010 Feb |
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| Analysis of multiple anticoagulant rodenticides in animal blood and liver tissue using principles of QuEChERS method. | 2010 Jun |
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| Validation of a new liquid chromatography- tandem mass spectrometry ion-trap technique for the simultaneous determination of thirteen anticoagulant rodenticides, drugs, or natural products. | 2010 Mar |
Patents
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Mixture
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EPA PESTICIDE CODE |
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DIFETHIALONE
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7119
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difethialone
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C060340
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m4428
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SUB33152
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DTXSID4032374
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KOL4VXI5O0
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104653-34-1
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91771
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