FLORBENAZINE F-18

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H32FNO3
Molecular Weight	364.4846
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@]12C[C@@H](O)[C@H](CC(C)C)CN1CCC3=CC(OCCC[18F])=C(OC)C=C23

InChI

InChIKey=GNKGXQHHUUEYQV-WTHAECTESA-N

InChI=1S/C21H32FNO3/c1-14(2)9-16-13-23-7-5-15-10-21(26-8-4-6-22)20(25-3)11-17(15)18(23)12-19(16)24/h10-11,14,16,18-19,24H,4-9,12-13H2,1-3H3/t16-,18-,19-/m1/s1/i22-1

HIDE SMILES / InChI

Molecular Formula	C21H32FNO3
Molecular Weight	364.4846
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67549477 | https://www.ncbi.nlm.nih.gov/pubmed/27157484 | https://clinicaltrials.gov/ct2/show/NCT01550484

FLORBENAZINE F-18 is a fluorinated vesicular monoamine transporter type 2 (VMAT-2) ligand for positron-emission tomography. It has completed Phase II/III as a commercial radiopharmaceutical for the early detection and monitoring of neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, and dementia with Lewy bodies.

CNS Activity

Approval Year

PubMed

Title	Date	PubMed
(18)F-AV-133: A Selective VMAT2-binding Radiopharmaceutical for PET Imaging of Dopaminergic Neurons.	2010 Jan	27157484
Management Impact of Imaging Brain Vesicular Monoamine Transporter Type 2 in Clinically Uncertain Parkinsonian Syndrome with (18)F-AV133 and PET.	2017 Nov	28490469
Diagnostic accuracy of imaging brain vesicular monoamine transporter type 2 (VMAT2) in clinically uncertain parkinsonian syndrome (CUPS): a 3-year follow-up study in community patients.	2018 Nov 15	30446576

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:02:54 UTC 2023` Edited by `admin` on `Fri Dec 15 19:02:54 UTC 2023`
Record UNII	KM31LBX59H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLORBENAZINE F-18

Common Name

English

(18F)-FP-(+)-DTBZ

Common Name

English

(2R,3R,11BR)-9-(3-((SUP 18)F)FLUOROPROPOXY)-10-METHOXY-3-(2-METHYLPROPYL)-1,3,4,6,7,11B- HEXAHYDRO-2H-BENZO(A)QUINOLIZIN-2-OL

Common Name

English

DTBZ F-18

Common Name

English

2H-BENZO(A)QUINOLIZIN-2-OL, 9-(3-(FLUORO-(SUP 18)F)PROPOXY)-1,3,4,6,7,11B-HEXAHYDRO-10- METHOXY-3-(2-METHYLPROPYL)-, (2R,3R,11BR)-

Common Name

English

FLORBENAZINE F 18

Official Name

English

FLORBENAZINE (18F)

Official Name

English

(18F)AV 133

Code

English

florbenazine (¹⁸F) [INN]

Common Name

English

AV-133 F-18

Code

English

Florbenazine (18f) [WHO-DD]

Common Name

English

FLORBENAZINE, F-18

Common Name

English

FLORBENAZINE F 18 [USAN]

Common Name

English

18F-DTBZ

Common Name

English

(18F)AV-133

Code

English

18F-AV-133

Code

English

Code System Code Type Description

NCI_THESAURUS

C171883