U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C21H32FNO3
Molecular Weight 364.4846
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FLORBENAZINE F-18

SMILES

[H][C@]12C[C@@H](O)[C@H](CC(C)C)CN1CCC3=CC(OCCC[18F])=C(OC)C=C23

InChI

InChIKey=GNKGXQHHUUEYQV-WTHAECTESA-N
InChI=1S/C21H32FNO3/c1-14(2)9-16-13-23-7-5-15-10-21(26-8-4-6-22)20(25-3)11-17(15)18(23)12-19(16)24/h10-11,14,16,18-19,24H,4-9,12-13H2,1-3H3/t16-,18-,19-/m1/s1/i22-1

HIDE SMILES / InChI

Molecular Formula C21H32FNO3
Molecular Weight 364.4846
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 3 / 3
E/Z Centers 0
Optical Activity UNSPECIFIED

FLORBENAZINE F-18 is a fluorinated vesicular monoamine transporter type 2 (VMAT-2) ligand for positron-emission tomography. It has completed Phase II/III as a commercial radiopharmaceutical for the early detection and monitoring of neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, and dementia with Lewy bodies.

Approval Year

PubMed

PubMed

TitleDatePubMed
Substance Class Chemical
Created
by admin
on Fri Dec 15 19:02:54 UTC 2023
Edited
by admin
on Fri Dec 15 19:02:54 UTC 2023
Record UNII
KM31LBX59H
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FLORBENAZINE F-18
Common Name English
(18F)-FP-(+)-DTBZ
Common Name English
(2R,3R,11BR)-9-(3-((SUP 18)F)FLUOROPROPOXY)-10-METHOXY-3-(2-METHYLPROPYL)-1,3,4,6,7,11B- HEXAHYDRO-2H-BENZO(A)QUINOLIZIN-2-OL
Common Name English
DTBZ F-18
Common Name English
2H-BENZO(A)QUINOLIZIN-2-OL, 9-(3-(FLUORO-(SUP 18)F)PROPOXY)-1,3,4,6,7,11B-HEXAHYDRO-10- METHOXY-3-(2-METHYLPROPYL)-, (2R,3R,11BR)-
Common Name English
FLORBENAZINE F 18
USAN  
USAN  
Official Name English
FLORBENAZINE (18F)
INN   WHO-DD  
INN  
Official Name English
(18F)AV 133
Code English
florbenazine (¹⁸F) [INN]
Common Name English
AV-133 F-18
Code English
Florbenazine (18f) [WHO-DD]
Common Name English
FLORBENAZINE, F-18
Common Name English
FLORBENAZINE F 18 [USAN]
Common Name English
18F-DTBZ
Common Name English
(18F)AV-133
Code English
18F-AV-133
Code English
Code System Code Type Description
NCI_THESAURUS
C171883
Created by admin on Fri Dec 15 19:02:54 UTC 2023 , Edited by admin on Fri Dec 15 19:02:54 UTC 2023
PRIMARY
MESH
C549477
Created by admin on Fri Dec 15 19:02:54 UTC 2023 , Edited by admin on Fri Dec 15 19:02:54 UTC 2023
PRIMARY
FDA UNII
KM31LBX59H
Created by admin on Fri Dec 15 19:02:54 UTC 2023 , Edited by admin on Fri Dec 15 19:02:54 UTC 2023
PRIMARY
USAN
XX-53
Created by admin on Fri Dec 15 19:02:54 UTC 2023 , Edited by admin on Fri Dec 15 19:02:54 UTC 2023
PRIMARY
ChEMBL
CHEMBL579217
Created by admin on Fri Dec 15 19:02:54 UTC 2023 , Edited by admin on Fri Dec 15 19:02:54 UTC 2023
PRIMARY
INN
9376
Created by admin on Fri Dec 15 19:02:54 UTC 2023 , Edited by admin on Fri Dec 15 19:02:54 UTC 2023
PRIMARY
DRUG BANK
DB14945
Created by admin on Fri Dec 15 19:02:54 UTC 2023 , Edited by admin on Fri Dec 15 19:02:54 UTC 2023
PRIMARY
PUBCHEM
17755050
Created by admin on Fri Dec 15 19:02:54 UTC 2023 , Edited by admin on Fri Dec 15 19:02:54 UTC 2023
PRIMARY
SMS_ID
300000037058
Created by admin on Fri Dec 15 19:02:54 UTC 2023 , Edited by admin on Fri Dec 15 19:02:54 UTC 2023
PRIMARY
EPA CompTox
DTXSID50241926
Created by admin on Fri Dec 15 19:02:54 UTC 2023 , Edited by admin on Fri Dec 15 19:02:54 UTC 2023
PRIMARY
CAS
956903-29-0
Created by admin on Fri Dec 15 19:02:54 UTC 2023 , Edited by admin on Fri Dec 15 19:02:54 UTC 2023
PRIMARY
Related Record Type Details
TARGET->RADIOLIGAND
NON-LABELED -> LABELED
Related Record Type Details
ACTIVE MOIETY