Pradusinstobart

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 04:56:21 GMT 2025` Edited by `admin` on `Wed Apr 02 04:56:21 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	KGF2Q3P9BJ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Pradusinstobart

Official Name

English

LVGN-3616

Preferred Name

English

pradusinstobart [INN]

Common Name

English

LVGN3616

Code

English

immunoglobulin G4-kappa, anti-[Homo sapiens PDCD1 (programmed cell death 1, PD1, PD-1, CD279)], humanized monoclonal antibody (gamma4 heavy chain humanized (1-448) [VH humanized (Homo sapiens IGHV2-5*08 (89.0%) -(IGHD) -IGHJ5*01 (86.7%), CDR-IMGT [10.7.1

Common Name

English

Immunoglobulin G4 [229-proline], anti-(human programmed cell death protein 1) (human-Mus musculus monoclonal LVGN3616 ?4-chain), disulfide with human-Mus musculus monoclonal LVGN3616 ?-chain, dimer

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C178280

Created by admin on Wed Apr 02 04:56:21 GMT 2025 , Edited by admin on Wed Apr 02 04:56:21 GMT 2025

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SMS_ID

300000046982

Created by admin on Wed Apr 02 04:56:21 GMT 2025 , Edited by admin on Wed Apr 02 04:56:21 GMT 2025

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FDA UNII

KGF2Q3P9BJ

Created by admin on Wed Apr 02 04:56:21 GMT 2025 , Edited by admin on Wed Apr 02 04:56:21 GMT 2025

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INN

12375

Created by admin on Wed Apr 02 04:56:21 GMT 2025 , Edited by admin on Wed Apr 02 04:56:21 GMT 2025

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CAS

2642171-66-0

Created by admin on Wed Apr 02 04:56:21 GMT 2025 , Edited by admin on Wed Apr 02 04:56:21 GMT 2025

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From	To
1_22	1_35
1_368	1_426
2_148	2_204
2_262	2_322
2_368	2_426
1_97	1_135
1_262	1_322
1_54	3_213
1_148	1_204
1_227	2_227
1_230	2_230
2_22	2_35
2_54	4_213
2_97	2_135
3_23	3_88
3_133	3_193
4_23	4_88
4_133	4_193

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_298
N	2_298

Related Record Type Details


					KGF2Q3P9BJ

Pradusinstobart

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_448] [2_448]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL