Verzistobart

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 14:31:04 UTC 2023` Edited by `admin` on `Sat Dec 16 14:31:04 UTC 2023`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	KAC8QY6TMN
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Verzistobart

Official Name

English

INCAGN 02390 [WHO-DD]

Common Name

English

Immunoglobulin G1 [300-alanine,de-C-terminal-lysine], anti-(human T-cell immunoglobulin and mucin domain 3) (human monoclonal INCAGN02390 γ1-chain), disulfide with human monoclonal INCAGN02390 κ-chain, dimer

Common Name

English

verzistobart [INN]

Common Name

English

Immunoglobulin G1-kappa, anti-[Homo sapiens HAVCR2 (hepatitis A virus cellular receptor 2, T cell immunoglobulin and mucin domains family member 3, TIM3, TIM-3, TIMD3, CD366)], Homo sapiens monoclonal antibody (gamma1 heavy chain Homo sapiens (1-449) [VH

Common Name

English

Code System Code Type Description

INN

12390

Created by admin on Sat Dec 16 14:31:04 UTC 2023 , Edited by admin on Sat Dec 16 14:31:04 UTC 2023

PRIMARY

CAS

2649466-18-0

Created by admin on Sat Dec 16 14:31:04 UTC 2023 , Edited by admin on Sat Dec 16 14:31:04 UTC 2023

PRIMARY

FDA UNII

KAC8QY6TMN

Created by admin on Sat Dec 16 14:31:04 UTC 2023 , Edited by admin on Sat Dec 16 14:31:04 UTC 2023

PRIMARY

NCI_THESAURUS

C162625

Created by admin on Sat Dec 16 14:31:04 UTC 2023 , Edited by admin on Sat Dec 16 14:31:04 UTC 2023

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_147	2_203
2_223	4_214
2_264	2_324
1_147	1_203
2_370	2_428
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_223	3_214
1_229	2_229
1_232	2_232
1_264	1_324
1_370	1_428

Related Record Type Details


					PBG9RMW5RU

HEPATITIS A VIRUS CELLULAR RECEPTOR 2

TARGET -> INHIBITOR

Comments:

INCAGN02390 also enhances IFNγ productionfrom T cells undergoing tonicTCR stimulation when combined with PD-1 blockade.

Amount:

Related Record Type Details


					KAC8QY6TMN

Verzistobart

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL