Volrustomig

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 00:53:35 GMT 2025` Edited by `admin` on `Wed Apr 02 00:53:35 GMT 2025`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	K96EGJ218N
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MEDI5752

Preferred Name

English

Volrustomig

Official Name

English

IMMUNOGLOBULIN G1 (134-CYSTEINE,228-VALINE,242-PHENYLALANINE,243-GLUTAMIC ACID,339-SERINE,362-CYSTEINE,374-TRYPTOPHAN), ANTI-(HUMAN CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED PROTEIN 4) (HUMAN MONOCLONAL MEDI5752 .GAMMA.1-CHAIN), DISULFIDE WITH (122-CYSTEINE,212-

Common Name

English

volrustomig [INN]

Common Name

English

MEDI-5752

Code

English

VOLRUSTOMIG [USAN]

Common Name

English

MEDI 5752 [WHO-DD]

Common Name

English

Code System Code Type Description

FDA UNII

K96EGJ218N

Created by admin on Wed Apr 02 00:53:35 GMT 2025 , Edited by admin on Wed Apr 02 00:53:35 GMT 2025

PRIMARY

INN

12168

Created by admin on Wed Apr 02 00:53:35 GMT 2025 , Edited by admin on Wed Apr 02 00:53:35 GMT 2025

PRIMARY

NCI_THESAURUS

C171937

Created by admin on Wed Apr 02 00:53:35 GMT 2025 , Edited by admin on Wed Apr 02 00:53:35 GMT 2025

PRIMARY

SMS_ID

300000043545

Created by admin on Wed Apr 02 00:53:35 GMT 2025 , Edited by admin on Wed Apr 02 00:53:35 GMT 2025

PRIMARY

CAS

2407760-40-9

Created by admin on Wed Apr 02 00:53:35 GMT 2025 , Edited by admin on Wed Apr 02 00:53:35 GMT 2025

PRIMARY

USAN

JK-67

Created by admin on Wed Apr 02 00:53:35 GMT 2025 , Edited by admin on Wed Apr 02 00:53:35 GMT 2025

PRIMARY

From	To
1_22	1_96
1_134	4_122
1_152	1_208
1_234	2_231
1_237	2_234
1_269	1_329
1_362	2_354
1_375	1_433
2_22	2_96
2_149	2_205
2_225	3_219
2_266	2_326
2_372	2_430
3_23	3_93
3_139	3_199
4_23	4_88
4_135	4_194

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_305
N	2_302

Related Record Type Details


					938DNF64FO

PROGRAMMED CELL DEATH PROTEIN 1

TARGET -> INHIBITOR

Comments:

Attenuate the inhibitory signals of CTLA-4 and PD-1 on T cells.

Amount:


					KYU4T5WAI2

CYTOTOXIC T-LYMPHOCYTE PROTEIN 4

TARGET -> INHIBITOR

Comments:

AttenuateA the inhibitory signals of CTLA-4 and PD-1. on T cells.

Amount:

Related Record Type Details


					K96EGJ218N

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [3_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_455] [2_452]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL