U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Jun 26 22:46:36 UTC 2021
Edited
by admin
on Sat Jun 26 22:46:36 UTC 2021
Source Materials Class ORGANISM
Source Materials Type AUTOLOGOUS HUMAN
Source Materials State LIVE GENETICALLY MODIFIED
Source Materials Parent
Part BLOOD
Fraction Material Type CELLS
Fraction Name CD8/CD4 T-CELLS
Record UNII
K8RW1TW3EM
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ORVACABTAGENE AUTOLEUCEL
USAN   INN  
Official Name English
ORVACABTAGENE AUTOLEUCEL [USAN]
Common Name English
JCARH125
Code English
ORVACABTAGENE AUTOLEUCEL [WHO-DD]
Common Name English
JCARH125 CONSISTS OF HUMAN CULTURE EXPANDED GENETICALLY MODIFIED AUTOLOGOUS T CELLS FOR CELL-BASED GENE THERAPY. CD4+ CD8+ T CELLS ARE DERIVED FROM ISOLATED BLOOD OF THE PATIENT AND ARE TRANSDUCED WITH NON-REPLICATIVE SELF-INACTIVATING (SIN) LENTIVIRAL V
Common Name English
JCARH-125
Code English
ORVACABTAGENE AUTOLEUCEL [INN]
Common Name English
Code System Code Type Description
INN
11274
Created by admin on Sat Jun 26 22:46:36 UTC 2021 , Edited by admin on Sat Jun 26 22:46:36 UTC 2021
PRIMARY
FDA UNII
K8RW1TW3EM
Created by admin on Sat Jun 26 22:46:36 UTC 2021 , Edited by admin on Sat Jun 26 22:46:36 UTC 2021
PRIMARY
NCI_THESAURUS
C147523
Created by admin on Sat Jun 26 22:46:36 UTC 2021 , Edited by admin on Sat Jun 26 22:46:36 UTC 2021
PRIMARY
Related Record Type Details
CHIMERIC PROTEIN ELEMENT->PARENT
TARGET -> INHIBITOR
CHIMERIC PROTEIN ELEMENT->PARENT
CHIMERIC PROTEIN ELEMENT->PARENT

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
VECTOR CO- EXPRESSED PROTEIN ELONGATION FACTOR 1-ALPHA 1 LE2P0TC7GI
VECTOR EXPRESSED PROTEIN UNSPECIFIED SUBSTANCE
05bef938
(not in database)