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Details

Stereochemistry RACEMIC
Molecular Formula C26H28N4O2.C4H4O4
Molecular Weight 544.5983
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of ZALDARIDE MALEATE

SMILES

OC(=O)\C=C/C(O)=O.CC4(CN1CCC(CC1)N2C(=O)NC3=C2C=CC=C3)OCC5=CC=CC=C5N6C=CC=C46

InChI

InChIKey=NGODOSILXOFQPH-BTJKTKAUSA-N
InChI=1S/C26H28N4O2.C4H4O4/c1-26(24-11-6-14-29(24)22-9-4-2-7-19(22)17-32-26)18-28-15-12-20(13-16-28)30-23-10-5-3-8-21(23)27-25(30)31;5-3(6)1-2-4(7)8/h2-11,14,20H,12-13,15-18H2,1H3,(H,27,31);1-2H,(H,5,6)(H,7,8)/b;2-1-

HIDE SMILES / InChI

Molecular Formula C4H4O4
Molecular Weight 116.0722
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Molecular Formula C26H28N4O2
Molecular Weight 428.5261
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

Zaldaride is a calmodulin antagonist known to produce inhibition of calmodulin-dependent voltage-gated ion channels including those of Ca2+, Na+, and K+. Zaldaride was also observed to inhibit nicotinic acetylcholine receptor (nAChR) channel currents. Zaldaride has been studied in clinical trials as a potential treatment for travelers diarrhea.

Originator

Approval Year

TargetsConditions

Conditions

PubMed

PubMed

TitleDatePubMed
CGS 9343B, a novel, potent, and selective inhibitor of calmodulin activity.
1987 May
Zaldaride maleate (a new calmodulin antagonist) versus loperamide in the treatment of traveler's diarrhea: randomized, placebo-controlled trial.
1995 Aug
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Treatment of traveler's diarrhea: 20 mg zaldaride maleate four times per day
Route of Administration: Oral
In Vitro Use Guide
Zaldaride (CGS 9343B) inhibited Kv currents in rabbit coronary arterial smooth muscle cells in a concentration-dependent manner, with a half-maximal inhibitory concentration (IC50) value of 0.81uM.
Substance Class Chemical
Created
by admin
on Tue Oct 22 19:48:38 UTC 2019
Edited
by admin
on Tue Oct 22 19:48:38 UTC 2019
Record UNII
K7SG01P7NJ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ZALDARIDE MALEATE
MART.   MI  
Common Name English
ZALDARIDE MALEATE [MI]
Common Name English
ZALDARIDE MALEATE [MART.]
Common Name English
1,3-DIHYDRO-1-(1-((4-METHYL-4H,6H-PYRROLO(1,2-A)(4,1)BENZOXAZEPIN-4-YL)METHYL)-4-PIPERIDINYL)-2H-BENZIMIDAZOL-2-ONE MALEATE
Systematic Name English
CGS-9434B
Code English
(+/-)-1-(1-((4-METHYL-4H,6H-PYRROLO(1,2-A)(4,1)BENZOXAZEPIN-4-YL)METHYL)-4-PIPERIDYL)-2-BENZIMIDAZOLINONE MALEATE
Systematic Name English
ZY-17617B
Code English
KW-5617
Code English
Code System Code Type Description
CAS
109826-27-9
Created by admin on Tue Oct 22 19:48:39 UTC 2019 , Edited by admin on Tue Oct 22 19:48:39 UTC 2019
PRIMARY
PUBCHEM
6450522
Created by admin on Tue Oct 22 19:48:39 UTC 2019 , Edited by admin on Tue Oct 22 19:48:39 UTC 2019
PRIMARY
MERCK INDEX
M11578
Created by admin on Tue Oct 22 19:48:39 UTC 2019 , Edited by admin on Tue Oct 22 19:48:39 UTC 2019
PRIMARY Merck Index
Related Record Type Details
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY