Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C26H28N4O2.C4H4O4 |
| Molecular Weight | 544.5983 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)\C=C/C(O)=O.CC4(CN1CCC(CC1)N2C(=O)NC3=CC=CC=C23)OCC5=C(C=CC=C5)N6C=CC=C46
InChI
InChIKey=NGODOSILXOFQPH-BTJKTKAUSA-N
InChI=1S/C26H28N4O2.C4H4O4/c1-26(24-11-6-14-29(24)22-9-4-2-7-19(22)17-32-26)18-28-15-12-20(13-16-28)30-23-10-5-3-8-21(23)27-25(30)31;5-3(6)1-2-4(7)8/h2-11,14,20H,12-13,15-18H2,1H3,(H,27,31);1-2H,(H,5,6)(H,7,8)/b;2-1-
| Molecular Formula | C4H4O4 |
| Molecular Weight | 116.0722 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
| Molecular Formula | C26H28N4O2 |
| Molecular Weight | 428.5261 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Zaldaride is a calmodulin antagonist known to produce inhibition of calmodulin-dependent voltage-gated ion channels including those of Ca2+, Na+, and K+. Zaldaride was also observed to inhibit nicotinic acetylcholine receptor (nAChR) channel currents. Zaldaride has been studied in clinical trials as a potential treatment for travelers diarrhea.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: Q14123 Gene ID: 5137.0 Gene Symbol: PDE1C Target Organism: Homo sapiens (Human) |
3.3 µM [IC50] | ||
Target ID: CHEMBL2362996 |
0.81 µM [IC50] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Curative | Unknown Approved UseUnknown |
Sample Use Guides
Treatment of traveler's diarrhea: 20 mg zaldaride maleate four times per day
Route of Administration:
Oral
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:45:36 GMT 2023
by
admin
on
Fri Dec 15 15:45:36 GMT 2023
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| Record UNII |
K7SG01P7NJ
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| Record Status |
Validated (UNII)
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109826-27-9
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m11578
Created by
admin on Fri Dec 15 15:45:36 GMT 2023 , Edited by admin on Fri Dec 15 15:45:36 GMT 2023
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PRIMARY | Merck Index |
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PARENT -> SALT/SOLVATE | |||
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |