Balekafusp alfa

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 10:19:02 GMT 2025` Edited by `admin` on `Wed Apr 02 10:19:02 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY FUSION PROTEIN
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	K6TVH24GM3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Balekafusp alfa

Official Name

English

Immunoglobulin G1 [301-alanine], anti-(human interleukin 2) (human-Mus musculus monoclonal ANV419 ?1-chain), disulfide with human-Mus musculus monoclonal ANV419 ?-chain N-terminal fragment fusion protein with peptide linker (GGG) fusion protein with (77-

Preferred Name

English

balekafusp alfa [INN]

Common Name

English

gamma 1 heavy chain (1-451) [VH (Homo sapiens IGHV5-51*01 -(IGHD) -IGHJ3*01, CDR-Kabat [5.17.12] (31-35.50-66.99-110)) (1-121) -Homo sapiens IGHG1*03 (CH1 (122-219), hinge (220-234), CH2 N><sup>301</sup>A (235-344), CH3 (345-449), CHS (450-451)) (122-451

Common Name

English

humanized immunoglobulin G1-kappa, anti-[human interleukin-2 (IL-2, T-cell growth factor, TCGF)] with an engineered kappa light chain, where a circular permuted form of human interleukin-2 is inserted within CDR-L1 between Y<sup>31</sup>(Kabat L.27D) and

Common Name

English

Code System Code Type Description

FDA UNII

K6TVH24GM3

Created by admin on Wed Apr 02 10:19:02 GMT 2025 , Edited by admin on Wed Apr 02 10:19:02 GMT 2025

PRIMARY

CAS

2866185-77-3

Created by admin on Wed Apr 02 10:19:02 GMT 2025 , Edited by admin on Wed Apr 02 10:19:02 GMT 2025

PRIMARY

INN

13040

Created by admin on Wed Apr 02 10:19:02 GMT 2025 , Edited by admin on Wed Apr 02 10:19:02 GMT 2025

PRIMARY

From	To
4_275	4_335
4_63	4_148
4_23	4_229
3_275	3_335
3_63	3_148
3_23	3_229
2_224	4_355
1_224	3_355
2_371	2_429
2_265	2_325
2_148	2_204
2_22	2_96
1_371	1_429
1_265	1_325
1_233	2_233
1_230	2_230
1_148	1_204
1_22	1_96

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
O	3_93
O	4_93

Related Record Type Details


					K6TVH24GM3

Balekafusp alfa

ACTIVE MOIETY

Comments:

presenting IL-2 to the IL-2R beta/IL-2R gamma complex and signaling preferentially via the dimeric receptor

Interaction Type:

PRECLINICAL

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_451] [2_451]	C-TERMINUS	K		LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL