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Description
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/26581493 | http://pubs.acs.org/doi/abs/10.1021/ic50099a028?journalCode=inocaj | http://pubs.acs.org/doi/abs/10.1021/ic50048a017?journalCode=inocaj | https://clinicaltrials.gov/ct2/show/NCT01484470 | https://www.ncbi.nlm.nih.gov/pubmed/18209724 | https://www.ncbi.nlm.nih.gov/pubmed/16219531

Tetraethylenepentamine (TEPA) is a low-molecular-weight linear polyamine exerting metal-chelating properties. TEPA is widely used in industrial applications. The principal hazards that arise in working with TEPA are those associated with similar organic amines; namely, a corrosive action on skin and eyes. TEPA biological activity was attributed to its effect on cellular Cu levels as (a) treatment with TEPA resulted in reduction of cellular Cu, and (b) excess of Cu reversed TEPA's activity and accelerated differentiation. TEPA was shown to attenuate the differentiation of ex vivo cultured hematopoietic cells resulting in preferential expansion of early progenitors. A phase I/II trial was performed to test the feasibility and safety of transplantation of CD133+ cord blood (CB) hematopoietic progenitors cultured in media containing stem cell factor, FLT-3 ligand, interleukin-6, thrombopoietin and TEPA. Transplanting a population of CD133+ CB cells which were expanded ex vivo for 21 days using SCF, FLT3, IL-6, TPO and the copper chelator TEPA (StemEx) was feasible. The expanded cells were well tolerated, with no infusion-related adverse events observed.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
StemEx

Approved Use

Unknown
Palliative
COLESTID

Approved Use

COLESTID Granules and FLAVORED COLESTID Granules are indicated as adjunctive therapy to diet for the reduction of elevated serum total and low-density lipoprotein (LDL) cholesterol in patients with primary hypercholesterolemia (elevated low density lipoproteins [LDL] cholesterol) who do not respond adequately to diet. Generally, COLESTID and FLAVORED COLESTID have no clinically significant effect on serum triglycerides, but with its use triglyceride levels may be raised in some patients.

Launch Date

2.28959994E11
PubMed

PubMed

TitleDatePubMed
Application of capillary electrophoresis for organic acid analysis in herbal studies.
2001 Jul
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.
2006 Nov
Patents

Sample Use Guides

The recommended daily adult dose is 5-30 g (granules) or 2-16 g (tablets) given once or in divided doses.
Route of Administration: Oral
In vitro binding capacity is 1 mequiv cholic acid/g.
Substance Class Polymer
Created
by admin
on Sat Dec 16 13:14:41 UTC 2023
Edited
by admin
on Sat Dec 16 13:14:41 UTC 2023
Record UNII
K50N755924
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
COLESTIPOL
INN   MI   VANDF   WHO-DD  
INN  
Official Name English
POLY(EPICHLOROHYDRIN-CO-TETRAETHYLENEPENTAMINE)
Common Name English
COPOLYMER OF DIETHYLENETRIAMINE AND 1-CHLORO-2,3-EPOXYPROPANE
Common Name English
colestipol [INN]
Common Name English
COLESTIPOL [VANDF]
Common Name English
NSC-147003
Code English
COLESTIPOL [MI]
Common Name English
Colestipol [WHO-DD]
Common Name English
Classification Tree Code System Code
LIVERTOX NBK548432
Created by admin on Sat Dec 16 13:14:41 UTC 2023 , Edited by admin on Sat Dec 16 13:14:41 UTC 2023
NDF-RT N0000175365
Created by admin on Sat Dec 16 13:14:41 UTC 2023 , Edited by admin on Sat Dec 16 13:14:41 UTC 2023
WHO-ATC C10AC02
Created by admin on Sat Dec 16 13:14:41 UTC 2023 , Edited by admin on Sat Dec 16 13:14:41 UTC 2023
NCI_THESAURUS C98148
Created by admin on Sat Dec 16 13:14:41 UTC 2023 , Edited by admin on Sat Dec 16 13:14:41 UTC 2023
NDF-RT N0000180292
Created by admin on Sat Dec 16 13:14:41 UTC 2023 , Edited by admin on Sat Dec 16 13:14:41 UTC 2023
Code System Code Type Description
FDA UNII
K50N755924
Created by admin on Sat Dec 16 13:14:41 UTC 2023 , Edited by admin on Sat Dec 16 13:14:41 UTC 2023
PRIMARY
MERCK INDEX
m3729
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PRIMARY Merck Index
MESH
D003084
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PRIMARY
PUBCHEM
62816
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PRIMARY
INN
2738
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PRIMARY
CAS
26658-42-4
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PRIMARY
RXCUI
2685
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PRIMARY RxNorm
LACTMED
Colestipol
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PRIMARY
WIKIPEDIA
COLESTIPOL
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PRIMARY
NCI_THESAURUS
C81540
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PRIMARY
DRUG CENTRAL
728
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PRIMARY
CHEBI
3814
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PRIMARY
DRUG BANK
DB00375
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PRIMARY
DAILYMED
K50N755924
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PRIMARY
EVMPD
SUB01425MIG
Created by admin on Sat Dec 16 13:14:41 UTC 2023 , Edited by admin on Sat Dec 16 13:14:41 UTC 2023
PRIMARY
NSC
147003
Created by admin on Sat Dec 16 13:14:41 UTC 2023 , Edited by admin on Sat Dec 16 13:14:41 UTC 2023
PRIMARY
EPA CompTox
DTXSID901009549
Created by admin on Sat Dec 16 13:14:41 UTC 2023 , Edited by admin on Sat Dec 16 13:14:41 UTC 2023
PRIMARY
SMS_ID
100000087961
Created by admin on Sat Dec 16 13:14:41 UTC 2023 , Edited by admin on Sat Dec 16 13:14:41 UTC 2023
PRIMARY
Display Structure of COLESTIPOL