U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Description

CB-13 is a cannabinoid drug, which acts as a potent agonist at both the CB1 and CB2 receptors, but has poor blood-brain barrier penetration, and so produces only peripheral effects at low doses, with symptoms of central effects such as catalepsy only appearing at much higher dose ranges. CB-13 displays antihyperalgesic activity in a rat model of neuropathic pain with no CNS side effects.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
6.1 nM [EC50]
27.9 nM [EC50]
80800.0 nM [IC50]
10.0 nM [Ki]
42.0 nM [Ki]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown
Primary
Sativex
Primary
Sativex
Primary
Sativex
Primary
Sativex

PubMed

Sample Use Guides

In Vivo Use Guide
2.7 mg delta-9-tetrahydrocannabinol (THC) and 2.5 mg cannabidiol (CBD), maximum dose (12 puffs): 32.4 mg THC/30 mg CBD
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Mixture
Record UNII
K4H93P747O
Record Status Validated (UNII)
Record Version
All of the following components must be present:
Definition References
(2)