Vortosiran

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 21:17:21 GMT 2025` Edited by `admin` on `Wed Apr 02 21:17:21 GMT 2025`
Nucleic Acid Type	dsRNA
Sequence Origin	SYNTHETIC
Sequence Type	COMPLETE
Record UNII	K4A9V4HK29
Record Status	`FAILED`
Record Version

Download

Name

Type

Language

Vortosiran

Official Name

English

(2RS)-3-(1,23-bis[(2-acetamido-2-deoxy-?-Dgalactopyranosyl) oxy]-14-{5-[(2-acetamido-2-deoxy-?-Dgalactopyranosyl) oxy]pentanoyl}-5,19-dioxo-6,10,14,18-tetraazatricosan-10-yl)-2-hydroxy-3-oxopropyl hydrogen all-Pambo-2'-O-methyl-P-thioguanylyl-(3'?5')-2'-

Preferred Name

English

RNA, (Cm-sp-(2?-deoxy-2?-fluoro)A-sp-Gm-Am-Am-(2?-deoxy-2?-fluoro)U-Cm-Cm-Am-Gm-Um-Cm-Cm-(2?-deoxy-2?-fluoro)A-Cm-(2?-deoxy-2?-fluoro)G-Um-Am-Cm-sp-Um-sp-Um), complex with RNA (Gm-sp-Um-sp-Am-Cm-Gm-Um-(2?-deoxy-2?-fluoro)G-(2?-deoxy-2?-fluoro)G-(2?-deoxy

Common Name

English

vortosiran [INN]

Common Name

English

Code System Code Type Description

CAS

3061406-99-0

Created by admin on Wed Apr 02 21:17:21 GMT 2025 , Edited by admin on Wed Apr 02 21:17:21 GMT 2025

PRIMARY

INN

13491

Created by admin on Wed Apr 02 21:17:21 GMT 2025 , Edited by admin on Wed Apr 02 21:17:21 GMT 2025

PRIMARY

FDA UNII

K4A9V4HK29

Created by admin on Wed Apr 02 21:17:21 GMT 2025 , Edited by admin on Wed Apr 02 21:17:21 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
2'-Fluoro-Ribose	1_2;1_6;1_14;1_16;2_7-2_9	7 / 40
2'-O-Methyl-Ribose	1_1;1_3-1_5;1_7-1_13;1_15;1_17-1_21;2_1-2_6;2_10-2_19	33 / 40

Linkage	Site Range	Site Count
Phosporothioate	1_2-1_3;1_19-1_21;2_1-2_3	8 / 38
Phosphate	1_4-1_18;2_4-2_19	31 / 38

Related Record Type Details


					ZK6M4PA6QA

COAGULATION FACTOR XI

TARGET->INHIBITOR OF EXPRESSION

Amount:

Related Record Type Details


					K4A9V4HK29

Vortosiran

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION		3'-TERMINUS	G		Vortosiran 3'-guanosine modification	Z2NK85Z4VJ