Patecibart

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National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 02:41:08 GMT 2025` Edited by `admin` on `Wed Apr 02 02:41:08 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	K3KZN98GF5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GMA301

Preferred Name

English

Patecibart

Official Name

English

Immunoglobulin G4-kappa, anti-[Homo sapiens EDNRA (endothelin receptor type A, ETA, ET-A, ETA-R, ET-AR)], humanized monoclonal antibody (gamma4 heavy chain humanized (1-446) [VH (Homo sapiens IGHV2-5*09 (88.9%) -(IGHD) -IGHJ4*01 (93.3%), CDR-IMGT [10.7.1

Common Name

English

GETAGOZUMAB

Common Name

English

GMA-301

Common Name

English

patecibart [INN]

Common Name

English

Immunoglobulin G4 [228-proline,234-alanine,235-alanine,de-447-lysine], anti-(human endothelin ETA receptor) (human-Mus musculus monoclonal GMA301 ?4-chain), disulfide with human-Mus musculus monoclonal GMA301 ?-chain, dimer

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C199087

Created by admin on Wed Apr 02 02:41:08 GMT 2025 , Edited by admin on Wed Apr 02 02:41:08 GMT 2025

PRIMARY

FDA UNII

K3KZN98GF5

Created by admin on Wed Apr 02 02:41:08 GMT 2025 , Edited by admin on Wed Apr 02 02:41:08 GMT 2025

PRIMARY

INN

12333

Created by admin on Wed Apr 02 02:41:08 GMT 2025 , Edited by admin on Wed Apr 02 02:41:08 GMT 2025

PRIMARY

SMS_ID

300000011222

Created by admin on Wed Apr 02 02:41:08 GMT 2025 , Edited by admin on Wed Apr 02 02:41:08 GMT 2025

PRIMARY

CAS

2642374-04-5

Created by admin on Wed Apr 02 02:41:08 GMT 2025 , Edited by admin on Wed Apr 02 02:41:08 GMT 2025

PRIMARY

From	To
1_22	1_97
1_134	3_214
1_147	1_203
1_226	2_226
1_229	2_229
1_261	1_321
1_367	1_425
2_22	2_97
2_134	4_214
2_147	2_203
2_261	2_321
2_367	2_425
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_297
N	2_297

Related Record Type Details


					5Q6PN7AC39

ENDOTHELIN-1 RECEPTOR

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					K3KZN98GF5

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER AVERAGE	CHEMICAL
Molecular Formula	CHEMICAL