Silevimig

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 18:03:36 GMT 2025` Edited by `admin` on `Wed Apr 02 18:03:36 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	K3CR9VL7SE
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Immunoglobulin (G1_L-kappa)_scFv-G1(h-CH2-CH3), anti-[rabies lyssavirus (rabies virus, RABV) glycoprotein G epitope III] and anti-[rabies lyssavirus (rabies virus, RABV) glycoprotein G epitope I] Homo sapiens monoclonal antibody, bispecific

Preferred Name

English

Silevimig

Official Name

English

Immunoglobulin, anti-(rabies virus spike glycoprotein G) (human clone S2E3 single-chain Fv fragment VH-(GGGGS)3-VL) fusion protein with immunoglobulin G1 [5-serine,134-cysteine,151-serine,153-alanine,192-valine] (human ?1-chain C region C-terminal fragme

Common Name

English

silevimig [INN]

Common Name

English

Code System Code Type Description

INN

12660

Created by admin on Wed Apr 02 18:03:36 GMT 2025 , Edited by admin on Wed Apr 02 18:03:36 GMT 2025

PRIMARY

FDA UNII

K3CR9VL7SE

Created by admin on Wed Apr 02 18:03:36 GMT 2025 , Edited by admin on Wed Apr 02 18:03:36 GMT 2025

PRIMARY

NCI_THESAURUS

C203188

Created by admin on Wed Apr 02 18:03:36 GMT 2025 , Edited by admin on Wed Apr 02 18:03:36 GMT 2025

PRIMARY

CAS

2618667-99-3

Created by admin on Wed Apr 02 18:03:36 GMT 2025 , Edited by admin on Wed Apr 02 18:03:36 GMT 2025

PRIMARY

From	To
4_134	4_194
4_23	4_88
3_134	3_194
3_23	3_88
1_390	2_355
1_270	2_230
1_267	2_227
2_221	4_214
1_408	1_466
1_302	1_362
1_164	1_232
1_22	1_96
2_368	2_426
2_262	2_322
2_145	2_201
2_22	2_96

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_338
N	2_298

Related Record Type Details


					I0V66KI1LD

RABIES VIRUS

TARGET ORGANISM->INHIBITOR

Amount:

Related Record Type Details


					K3CR9VL7SE

Silevimig

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_488] [2_448]	C-TERMINUS	K		LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL