MK-6186

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H12Cl2N6O
Molecular Weight	435.266
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC1=CC(=CC(OC2=C(Cl)C=CC3=C2C=NN3CC4=NNC5=NC=CC=C45)=C1)C#N

InChI

InChIKey=FZBAOOQVQXATRL-UHFFFAOYSA-N

InChI=1S/C21H12Cl2N6O/c22-13-6-12(9-24)7-14(8-13)30-20-16-10-26-29(19(16)4-3-17(20)23)11-18-15-2-1-5-25-21(15)28-27-18/h1-8,10H,11H2,(H,25,27,28)

HIDE SMILES / InChI

Molecular Formula	C21H12Cl2N6O
Molecular Weight	435.266
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22391531 | https://www.ncbi.nlm.nih.gov/pubmed/21985673 | https://www.ncbi.nlm.nih.gov/pubmed/22071300

MK-6186 is a novel nonnucleoside reverse transcriptase inhibitor (NNRTI) which displays subnanomolar potency against wild-type (WT) HIV virus and the two most prevalent NNRTI-resistant RT mutants (K103N and Y181C) in biochemical assays. In addition, it showed excellent antiviral potency against K103N and Y181C mutant viruses. In 2010 MK-6186 was studied in phase I clinical trials but no further development reports were published.

Originator

Approval Year

PubMed

Title	Date	PubMed
Design and synthesis of conformationally constrained inhibitors of non-nucleoside reverse transcriptase.	2011 Nov 24	21985673
Antiviral activity and in vitro mutation development pathways of MK-6186, a novel nonnucleoside reverse transcriptase inhibitor.	2012 Jun	22391531

Patents

Sample Use Guides

In Vivo Use Guide

150 mg oral dose once daily for 7 days

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:24:08 UTC 2023` Edited by `admin` on `Sat Dec 16 08:24:08 UTC 2023`
Record UNII	K3978U665M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MK-6186

Common Name

English

BENZONITRILE, 3-CHLORO-5-((5-CHLORO-1-(1H-PYRAZOLO(3,4-B)PYRIDIN-3-YLMETHYL)-1H-INDAZOL-4-YL)OXY)-

Systematic Name

English

MK6186

Code

English

Code System Code Type Description

FDA UNII

K3978U665M