METHYL HESPERIDIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C29H36O15
Molecular Weight	624.5871
Optical Activity	UNSPECIFIED
Defined Stereocenters	11 / 11
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(C=C1OC)[C@@H]2CC(=O)C3=C(O)C=C(O[C@@H]4O[C@H](CO[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)C=C3O2

InChI

InChIKey=GUMSHIGGVOJLBP-SLRPQMTOSA-N

InChI=1S/C29H36O15/c1-11-22(32)24(34)26(36)28(41-11)40-10-20-23(33)25(35)27(37)29(44-20)42-13-7-14(30)21-15(31)9-17(43-19(21)8-13)12-4-5-16(38-2)18(6-12)39-3/h4-8,11,17,20,22-30,32-37H,9-10H2,1-3H3/t11-,17-,20+,22-,23+,24+,25-,26+,27+,28+,29+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C29H36O15
Molecular Weight	624.5871
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	11 / 11
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/23220657

Methyl hesperidin is a flavanone-type flavonoid and a methylated derivative of hesperidin. It exhibits better bioactivities and water-solubility than hesperidin. It could improve the permeability and integrity of the capillary lining and usually found in association with vitamin C to enhance its effect.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Molecular spectroscopic on interaction between Methyl hesperidin and Buman serum albumin.	2013-02	23220657
Subchronic toxicity study of methyl hesperidin in mice.	1993-07	8356566
[Vasodilating action of methylhesperidin].	1987-07	3445778
[Effect of methyl hesperidin on the prenatal development of rats].	1986	3567442
The potentiating effect of methyl hesperidin on coronary vasodilation induced by adenosine or related compounds.	1967-08	5632073

Sample Use Guides

In Vivo Use Guide

In a preclinical study, mice were treated with dietary concentrations of 0, 1.25 or 5% for 96 weeks.

Route of Administration: Oral

In Vitro Use Guide

In a fluorescence titration experiment, 2.0 ml solution containing an appropriate concentration of BSA was titrated manually by successive addition of a 10(-3) mol/L solution of methyl hesperidin (to give a final concentration of 5*10(-6) mol/L to 4.76*10(-5) mol/L).

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:00:00 GMT 2025` Edited by `admin` on `Mon Mar 31 19:00:00 GMT 2025`
Record UNII	K324U7386B
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

METHYL HESPERIDIN

Official Name

English

4H-1-BENZOPYRAN-4-ONE, 7-((6-O-(6DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-.BETA.-D-GLUCOPYRANOSYL)OXY)-2,3-DIHYDRO-5-HYDROXY-2-(3,4-DIMETHOXYPHENYL)-, (2S)-

Preferred Name

English

Methyl hesperidin [WHO-DD]

Common Name

English

4H-1-BENZOPYRAN-4-ONE, 7-((6-O-(6DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-.BETA.-D-GLUCOPYRANOSYL)OXY)-2,3-DIHYDRO-5-HYDROXY-2-(3-HYDROXY-4-METHOXYPHENYL)-, MONOMETHYL ETHER, (2S)-

Common Name

English

METHYLHESPERIDIN

Common Name

English

Code System Code Type Description

PUBCHEM

5284419