Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C14H18N4O2S |
| Molecular Weight | 306.383 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC(CC2=CN=C(N)N=C2N)=CC(OC)=C1SC
InChI
InChIKey=HRZQMMXCASMDBP-UHFFFAOYSA-N
InChI=1S/C14H18N4O2S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
| Molecular Formula | C14H18N4O2S |
| Molecular Weight | 306.383 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Metioprim is a competitive inhibitor of bacterial dihydrofolate reductase with an in vitro activity against most important gram-negative and gram-positive bacteria causing urinary and respiratory tract infections. The use of this drug was studied in the treatment of pyelonephritis and against atypical mycobacterial infections - especially leprosy. Information about the current use of this compound is not available.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Pharmacokinetics and metabolism of metioprim in pigs and goats. | 1987-11 |
|
| Pharmacokinetics of metioprim in normal subjects and patients with impaired renal function. | 1983-08 |
|
| Bacterial growth kinetics of Escherichia coli and mycobacteria in the presence of brodimoprim and metioprim alone and in combination with sulfamerazine and dapsone (VI). | 1983 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 17:57:30 GMT 2025
by
admin
on
Mon Mar 31 17:57:30 GMT 2025
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| Record UNII |
K29KWU39J0
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| Record Status |
Validated (UNII)
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| Record Version |
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NCI_THESAURUS |
C258
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C036263
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C66126
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CHEMBL56318
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68902-57-8
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4721
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100000080933
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68590
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DTXSID60218982
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K29KWU39J0
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SUB08889MIG
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