MECLORISONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H28Cl2O4
Molecular Weight	427.361
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](Cl)[C@@]3(Cl)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

InChIKey=OKWSMPYQIYKVDC-CXSFZGCWSA-N

InChI=1S/C22H28Cl2O4/c1-12-8-16-15-5-4-13-9-14(26)6-7-19(13,2)21(15,24)17(23)10-20(16,3)22(12,28)18(27)11-25/h6-7,9,12,15-17,25,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C22H28Cl2O4
Molecular Weight	427.361
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://link.springer.com/book/10.1007/978-1-4757-2085-3#about | https://www.ncbi.nlm.nih.gov/pubmed/6032308 | https://www.ncbi.nlm.nih.gov/pubmed/4693737

Meclorisone is a synthetic corticosteroid exerting anti-inflammatory activity.

Approval Year

PubMed

Title	Date	PubMed
17-esters and 17,21-diesters of 9-alpha, 11-beta-dichlorocorticoids. Synthesis and anti-inflammatory activity.	1967 Feb	6032308
Biologic activity of 16 -methyldichlorisone-17-butyrate in the rat and dog.	1973 Mar	4693737

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:25:14 UTC 2023` Edited by `admin` on `Fri Dec 15 15:25:14 UTC 2023`
Record UNII	K18P43Q80N
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MECLORISONE

Official Name

English

PREGNA-1,4-DIENE-3,20-DIONE, 9,11-DICHLORO-16-METHYL-(11.BETA.,16.ALPHA.)-

Systematic Name

English

meclorisone [INN]

Common Name

English

NSC-92353

Code

English

9,11.BETA.-DICHLORO-17,21-DIHYDROXY-16.ALPHA.-METHYLPREGNA-1,4-DIENE-3,20-DIONE

Systematic Name

English

16.ALPHA.-METHYL-DICHLORISONE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C521