CYTIDINE TRIPHOSPHATE

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C9H16N3O14P3
Molecular Weight	483.1563
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O

InChI

InChIKey=PCDQPRRSZKQHHS-XVFCMESISA-N

InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C9H16N3O14P3
Molecular Weight	483.1563
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Targets

Primary Target	Pharmacology	Potency
Hepatitis C virus 23	Inhibitor 8,504
Reverse transcriptase 9	Inhibitor 8,504	1100.0 nM [Kd]
Purinergic receptor P2Y2 11	Agonist 2,752	44.0 nM [EC50]
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 4	Inhibitor 8,504

PubMed

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Title	Date	PubMed
Insights into the molecular mechanism of mitochondrial toxicity by AIDS drugs.	2001 Jun 29	11328813
Inhibition of Escherichia coli CTP synthase by glutamate gamma-semialdehyde and the role of the allosteric effector GTP in glutamine hydrolysis.	2001 May 15	11336655
Inhibition of purified recombinant reverse transcriptase from wild-type and zidovudine-resistant clinical isolates of human immunodeficiency virus type 1 by zidovudine, stavudine, and lamivudine triphosphates.	2001 Nov 15	11679926
Tumor uptake and elimination of 2',2'-difluoro-2'-deoxycytidine (gemcitabine) after deoxycytidine kinase gene transfer: correlation with in vivo tumor response.	2001 Oct	11595723
The cytostatic- and differentiation-inducing effects of cyclopentenyl cytosine on neuroblastoma cell lines.	2001 Oct 15	11597578

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Patents

Substance Class	Chemical
Record UNII	K0118UX80T
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CYTIDINE TRIPHOSPHATE

Systematic Name

English

5'-CTP

Preferred Name

English

Cytidine triphosphate [WHO-DD]

Common Name

English

ARA-CYTIDINE TRIPHOSPHATE

Common Name

English

CYTIDINE 5'-TRIPHOSPHATE

Systematic Name

English

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Classification Tree

Code System

Code

Nucleic Acids, Nucleosides, and Nucleotides

NCI_THESAURUS

C709

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Code System

Code

Type

Description

ECHA (EC/EINECS)

200-611-4

PRIMARY

SMS_ID

300000047532

PRIMARY

CHEBI

58231

PRIMARY

EPA CompTox

DTXSID70889324

PRIMARY

WIKIPEDIA

Cytidine triphosphate

PRIMARY

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Type

Details


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Cytidine 5’-triphosphate trisodium

SALT/SOLVATE -> PARENT

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CYTARABINE

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