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Details

Stereochemistry ABSOLUTE
Molecular Formula C9H16N3O14P3
Molecular Weight 483.1563
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CYTIDINE TRIPHOSPHATE

SMILES

NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O

InChI

InChIKey=PCDQPRRSZKQHHS-XVFCMESISA-N
InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1

HIDE SMILES / InChI

Molecular Formula C9H16N3O14P3
Molecular Weight 483.1563
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

PubMed

PubMed

TitleDatePubMed
On-line microdialysis for enhanced resolution and sensitivity during electrospray mass spectrometry of non-covalent complexes and competitive binding studies.
2002
Identification of lamin A/C ( LMNA) gene mutations in Korean patients with autosomal dominant Emery-Dreifuss muscular dystrophy and limb-girdle muscular dystrophy 1B.
2002
Novel direct detection method for quantitative determination of intracellular nucleoside triphosphates using weak anion exchange liquid chromatography/tandem mass spectrometry.
2002
[Preliminary clinical study of application of cyntridini triphosphatis and dexamethasone in treatment of sudden deafness].
2002 Aug
Severe pyridine nucleotide depletion in fibroblasts from Lesch-Nyhan patients.
2002 Aug 15
Interactions of enantiomers of 2',3'-didehydro-2',3'-dideoxy-fluorocytidine with wild type and M184V mutant HIV-1 reverse transcriptase.
2002 Dec
Crystal structures of the Bacillus stearothermophilus CCA-adding enzyme and its complexes with ATP or CTP.
2002 Dec 13
The role of intersubunit interactions for the stabilization of the T state of Escherichia coli aspartate transcarbamoylase.
2002 Dec 20
Stabilization of the R allosteric structure of Escherichia coli aspartate transcarbamoylase by disulfide bond formation.
2002 Dec 6
Argipressin(4-8) upregulate CTP: phosphocholine cytidylyltransferase in rat hippocampal neurons.
2002 Jul
3'-Azido-2',3'-dideoxythymidine induced deficiency of thymidine kinases 1, 2 and deoxycytidine kinase in H9 T-lymphoid cells.
2002 Jul 15
The oxidized pyrimidine ribonucleotide, 5-hydroxy-CTP, is hydrolyzed efficiently by the Escherichia coli recombinant Orf135 protein.
2002 Jul 17
Perspectives on the molecular mechanism of inhibition and toxicity of nucleoside analogs that target HIV-1 reverse transcriptase.
2002 Jul 18
Substrate regulation of calcium binding in Ca2+-ATPase molecules of the sarcoplasmic reticulum. II. Effect of CTP, GTP, ITP, and UTP.
2002 Jul 5
Polypeptide synthesis directed by DNA as a messenger in cell-free polypeptide synthesis by extreme thermophiles, Thermus thermophilus HB27 and Sulfolobus tokodaii strain 7.
2002 Jun
Development of a pharmacodynamic model for HIV treatment with nucleoside reverse transcriptase and protease inhibitors.
2002 Nov
Steady-state kinetics of the glutaminase reaction of CTP synthase from Lactococcus lactis. The role of the allosteric activator GTP incoupling between glutamine hydrolysis and CTP synthesis.
2002 Oct
Expression and characterization of a human cDNA that complements the temperature-sensitive defect in dolichol kinase activity in the yeast sec59-1 mutant: the enzymatic phosphorylation of dolichol and diacylglycerol are catalyzed by separate CTP-mediated kinase activities in Saccharomyces cerevisiae.
2002 Sep
Inhibitory activity of dioxolane purine analogs on wild-type and lamivudine-resistant mutants of hepadnaviruses.
2002 Sep
A77 1726 induces differentiation of human myeloid leukemia K562 cells by depletion of intracellular CTP pools.
2002 Sep
Retinoic acid reduces the cytotoxicity of cyclopentenyl cytosine in neuroblastoma cells.
2002 Sep 11
Distinct interactions of GTP, UTP, and CTP with G(s) proteins.
2002 Sep 13
An assay for cytidine 5(')-triphosphate synthetase glutaminase activity using high performance liquid chromatography.
2002 Sep 15
Differential processing of the Xenopus ATP(CTP):tRNA nucleotidyltransferase mRNA.
2002 Sep 27
Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs.
2003 Apr 4
In vitro studies of transcript initiation by Escherichia coli RNA polymerase. 3. Influences of individual DNA elements within the promoter recognition region on abortive initiation and promoter escape.
2003 Apr 8
In vitro studies of transcript initiation by Escherichia coli RNA polymerase. 2. Formation and characterization of two distinct classes of initial transcribing complexes.
2003 Apr 8
In vitro studies of transcript initiation by Escherichia coli RNA polymerase. 1. RNA chain initiation, abortive initiation, and promoter escape at three bacteriophage promoters.
2003 Apr 8
Fold recognition, homology modeling, docking simulations, kinetics analysis and mutagenesis of ATP/CTP:tRNA nucleotidyltransferase from Methanococcus jannaschii.
2003 Aug 15
Trapping specific quaternary states of the allosteric enzyme aspartate transcarbamoylase in silica matrix sol-gels.
2003 Aug 20
Association of the CD14 gene -159C polymorphism with progression of IgA nephropathy.
2003 Feb
Neighbouring bases in template influence base-pairing of isoguanine.
2003 Feb 1
Aspartate-107 and leucine-109 facilitate efficient coupling of glutamine hydrolysis to CTP synthesis by Escherichia coli CTP synthase.
2003 Feb 1
Effects of endogenous DNA base lesions on transcription elongation by mammalian RNA polymerase II. Implications for transcription-coupled DNA repair and transcriptional mutagenesis.
2003 Feb 28
HIV-1 resistance profile of the novel nucleoside reverse transcriptase inhibitor beta-D-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine (Reverset).
2003 Jan
Cellular pharmacology of D-d4FC, a nucleoside analogue active against drug-resistant HIV.
2003 Jan
[Research on motor dysfunction and the role of CTP after traumatic brain injury in rats].
2003 Jul
Nested cooperativity and salt dependence of the ATPase activity of the archaeal chaperonin Mm-cpn.
2003 Jul 17
Phosphorylation of CTP synthetase on Ser36, Ser330, Ser354, and Ser454 regulates the levels of CTP and phosphatidylcholine synthesis in Saccharomyces cerevisiae.
2003 Jun 6
Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons.
2003 Mar
NTP pattern of avian embryonic red cells: role of RNA degradation and AMP deaminase/5'-nucleotidase activity.
2003 Mar
CTP:glycerol 3-phosphate cytidylyltransferase (TarD) from Staphylococcus aureus catalyzes the cytidylyl transfer via an ordered Bi-Bi reaction mechanism with micromolar K(m) values.
2003 Mar 21
Limited proteolysis of Escherichia coli cytidine 5'-triphosphate synthase. Identification of residues required for CTP formation and GTP-dependent activation of glutamine hydrolysis.
2003 May
Dioxolane guanosine 5'-triphosphate, an alternative substrate inhibitor of wild-type and mutant HIV-1 reverse transcriptase. Steady state and pre-steady state kinetic analyses.
2003 May 23
Identification of lysine 122 and arginine 196 as important functional residues of rat CTP:phosphocholine cytidylyltransferase alpha.
2003 May 6
Crystal structures of an archaeal class I CCA-adding enzyme and its nucleotide complexes.
2003 Nov
Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure.
2003 Nov 3
Antiviral dynamics and sex differences of zidovudine and lamivudine triphosphate concentrations in HIV-infected individuals.
2003 Oct 17
Antiretroviral pipeline: new-drug reports from retroviruses conference.
2004 Feb 27
A fluorescent probe-labeled Escherichia coli aspartate transcarbamoylase that monitors the allosteric conformational state.
2004 Jan 9
Patents
Substance Class Chemical
Created
by admin
on Sat Dec 16 09:58:08 GMT 2023
Edited
by admin
on Sat Dec 16 09:58:08 GMT 2023
Record UNII
K0118UX80T
Record Status Validated (UNII)
Record Version
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Name Type Language
CYTIDINE TRIPHOSPHATE
WHO-DD  
Systematic Name English
Cytidine triphosphate [WHO-DD]
Common Name English
ARA-CYTIDINE TRIPHOSPHATE
Common Name English
CYTIDINE 5'-TRIPHOSPHATE
Systematic Name English
CTP
Common Name English
5'-CTP
Common Name English
CYTIDINE, MONO(TETRAHYDROGEN TRIPHOSPHATE) (ESTER)
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C709
Created by admin on Sat Dec 16 09:58:08 GMT 2023 , Edited by admin on Sat Dec 16 09:58:08 GMT 2023
Code System Code Type Description
ECHA (EC/EINECS)
200-611-4
Created by admin on Sat Dec 16 09:58:08 GMT 2023 , Edited by admin on Sat Dec 16 09:58:08 GMT 2023
PRIMARY
SMS_ID
300000047532
Created by admin on Sat Dec 16 09:58:08 GMT 2023 , Edited by admin on Sat Dec 16 09:58:08 GMT 2023
PRIMARY
CHEBI
58231
Created by admin on Sat Dec 16 09:58:08 GMT 2023 , Edited by admin on Sat Dec 16 09:58:08 GMT 2023
PRIMARY
EPA CompTox
DTXSID70889324
Created by admin on Sat Dec 16 09:58:08 GMT 2023 , Edited by admin on Sat Dec 16 09:58:08 GMT 2023
PRIMARY
WIKIPEDIA
Cytidine triphosphate
Created by admin on Sat Dec 16 09:58:08 GMT 2023 , Edited by admin on Sat Dec 16 09:58:08 GMT 2023
PRIMARY
NCI_THESAURUS
C126896
Created by admin on Sat Dec 16 09:58:08 GMT 2023 , Edited by admin on Sat Dec 16 09:58:08 GMT 2023
PRIMARY
FDA UNII
K0118UX80T
Created by admin on Sat Dec 16 09:58:08 GMT 2023 , Edited by admin on Sat Dec 16 09:58:08 GMT 2023
PRIMARY
CHEBI
17677
Created by admin on Sat Dec 16 09:58:08 GMT 2023 , Edited by admin on Sat Dec 16 09:58:08 GMT 2023
PRIMARY
CAS
65-47-4
Created by admin on Sat Dec 16 09:58:08 GMT 2023 , Edited by admin on Sat Dec 16 09:58:08 GMT 2023
PRIMARY
PUBCHEM
6176
Created by admin on Sat Dec 16 09:58:08 GMT 2023 , Edited by admin on Sat Dec 16 09:58:08 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> METABOLITE ACTIVE
PLASMA