Details
Stereochemistry | ACHIRAL |
Molecular Formula | C26H28N3.HO |
Molecular Weight | 399.528 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 1 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[OH-].CN(C)C1=CC2=C(C=C1)[N+](C)=C(\C=C\C3=C(C)N(C(C)=C3)C4=CC=CC=C4)C=C2
InChI
InChIKey=XSLHNXBPPDZDAU-UHFFFAOYSA-M
InChI=1S/C26H28N3.H2O/c1-19-17-21(20(2)29(19)24-9-7-6-8-10-24)11-13-23-14-12-22-18-25(27(3)4)15-16-26(22)28(23)5;/h6-18H,1-5H3;1H2/q+1;/p-1
Molecular Formula | C26H28N3 |
Molecular Weight | 382.5206 |
Charge | 1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 2 |
Optical Activity | NONE |
Molecular Formula | HO |
Molecular Weight | 17.0073 |
Charge | -1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Pyrvinium (Viprynium) is an anthelmintic effective for pinworms. Pyrvinium is used in the treatment of enterobiasis caused by Enterobius vermicularis (pinworm). Pyrvinium has being shown to be a potent inhibitor of Wnt signaling (EC(50) of ∼10 nM). Pyrvinium binds all casein kinase 1 (CK1) family members in vitro at low nanomolar concentrations and pyrvinium selectively potentiates casein kinase 1α (CK1α) kinase activity. Pyrvinium pamoate (PP) is a potent noncompetitive inhibitor of the androgen receptor (AR). A noncompetitive AR inhibitor pyrvinium has significant potential to treat CRPC, including cancers driven by ligand-independent AR signaling.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2793 |
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Target ID: CHEMBL612855 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18591280 |
354.0 nM [IC50] | ||
Target ID: CHEMBL1871 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Curative | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
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Curative | POVAN Approved UsePyrvinium is used to treat pinworms (enterobiasis). |
|||
Primary | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1269218
single 350-mg dose
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25060218
Pyrvinium blocked colon cancer cell growth in vitro in a dose-dependent manner with great differences in the inhibitory concentration (IC(50)), ranging from 0.6 × 10(-6) to 65 × 10(-6) mol/L for colon cancer cells with mutations in WNT signaling.
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:08:24 GMT 2023
by
admin
on
Sat Dec 16 10:08:24 GMT 2023
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Record UNII |
JZ0LJI3C3M
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Record Status |
Validated (UNII)
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Record Version |
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JZ0LJI3C3M
Created by
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641-69-0
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admin on Sat Dec 16 10:08:24 GMT 2023 , Edited by admin on Sat Dec 16 10:08:24 GMT 2023
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12314829
Created by
admin on Sat Dec 16 10:08:24 GMT 2023 , Edited by admin on Sat Dec 16 10:08:24 GMT 2023
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Related Record | Type | Details | ||
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ACTIVE MOIETY |