Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Wed Apr 02 17:38:35 GMT 2025
by
admin
on
Wed Apr 02 17:38:35 GMT 2025
|
| Protein Type | PEPTIDE |
| Protein Sub Type | |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
JW7KCN7MMK
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Preferred Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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Q66K64
Created by
admin on Wed Apr 02 17:38:35 GMT 2025 , Edited by admin on Wed Apr 02 17:38:35 GMT 2025
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PRIMARY | |||
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JW7KCN7MMK
Created by
admin on Wed Apr 02 17:38:35 GMT 2025 , Edited by admin on Wed Apr 02 17:38:35 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
DEGRADER->TARGET |
Indisulam induces a ternary protein complex between RNA Binding Motif 39 (RBM39) and the E3 ubiquitin ligase receptor DDB1 and CUL4 associated factor 15 (DCAF15) resulting in rapid proteasomal degradation of RBM39, aberrant RNA splicing and cell death.
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Structural Modifications
| Modification Type | Location Site | Location Type | Residue Modified | Extent | Fragment Name | Fragment Approval |
|---|---|---|---|---|---|---|
| AMINO_ACID_SUBSTITUTION | [1_50] [1_310] [1_314] | SITE_SPECIFIC | S | DEXFOSFOSERINE | VI4F0K069V |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| Molecular Formula | CHEMICAL |
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| MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
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