GAP JUNCTION ALPHA-1 PROTEIN

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 19:06:21 GMT 2025` Edited by `admin` on `Tue Apr 01 19:06:21 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	JW2WBR7BXU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GAP JUNCTION ALPHA-1 PROTEIN

Common Name

English

CONNEXIN-43

Preferred Name

English

CX43

Common Name

English

GAP JUNCTION 43 KDA HEART PROTEIN

Common Name

English

GJA1

Common Name

English

GJAL

Common Name

English

Code System Code Type Description

FDA UNII

JW2WBR7BXU

Created by admin on Tue Apr 01 19:06:21 GMT 2025 , Edited by admin on Tue Apr 01 19:06:21 GMT 2025

PRIMARY

UNIPROT

P17302

Created by admin on Tue Apr 01 19:06:21 GMT 2025 , Edited by admin on Tue Apr 01 19:06:21 GMT 2025

PRIMARY

From	To
1_53	1_191
1_186	1_197

Related Record Type Details


					GFA1W6KO7N

ROTIGAPTIDE

ACTIVATOR -> TARGET

Comments:

Rotigaptide has been shown to activate various protein kinase C (PKC) isoforms to cause the phosphorylation of Cx43, Rotigaptide (RG, ZP123) prevents of dephosphorylation and thereby uncoupling of 24 Connexin-43 (Cx43), possibly via action on unidentified protein phosphatases.


					PA0Y7735AT

DANEGAPTIDE

ACTIVATOR -> TARGET

Comments:

ZP1609 stabilizes plasma membrane associated Cx43 gap junctions to enhance gap junctional coupling

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT	CHEMICAL