GAP JUNCTION ALPHA-1 PROTEIN

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 12:22:15 UTC 2023` Edited by `admin` on `Sat Dec 16 12:22:15 UTC 2023`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	JW2WBR7BXU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GAP JUNCTION ALPHA-1 PROTEIN

Common Name

English

CX43

Common Name

English

GAP JUNCTION 43 KDA HEART PROTEIN

Common Name

English

GJA1

Common Name

English

GJAL

Common Name

English

CONNEXIN-43

Common Name

English

Code System Code Type Description

FDA UNII

JW2WBR7BXU

Created by admin on Sat Dec 16 12:22:15 UTC 2023 , Edited by admin on Sat Dec 16 12:22:15 UTC 2023

PRIMARY

UNIPROT

P17302

Created by admin on Sat Dec 16 12:22:15 UTC 2023 , Edited by admin on Sat Dec 16 12:22:15 UTC 2023

PRIMARY

From	To
1_53	1_191
1_186	1_197

Related Record Type Details


					GFA1W6KO7N

ROTIGAPTIDE

ACTIVATOR -> TARGET

Comments:

Rotigaptide has been shown to activate various protein kinase C (PKC) isoforms to cause the phosphorylation of Cx43, Rotigaptide (RG, ZP123) prevents of dephosphorylation and thereby uncoupling of 24 Connexin-43 (Cx43), possibly via action on unidentified protein phosphatases.


					PA0Y7735AT

DANEGAPTIDE

ACTIVATOR -> TARGET

Comments:

ZP1609 stabilizes plasma membrane associated Cx43 gap junctions to enhance gap junctional coupling

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT	CHEMICAL