Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C3H6FNO2 |
| Molecular Weight | 108.0898 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[2H][C@@](N)(CF)C(O)=O
InChI
InChIKey=UYTSRQMXRROFPU-LIIDHCAMSA-N
InChI=1S/C3H6FNO2/c4-1-2(5)3(6)7/h2H,1,5H2,(H,6,7)/t2-/m1/s1/i2D
| Molecular Formula | C3H6FNO2 |
| Molecular Weight | 108.0898 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
FLUDALANINE, an analog of D-alanine, is an anti-bacterial agent active against gram-negative and gram-positive bacteria. The antibacterial action results from a sequential blockade of the D-alanine biosynthesis by irreversible inhibition of bacterial alanine racemase. Thus, FLUDALANINE blocks incorporation of D-alanine into the bacterial cell wall.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Experimental pneumonia due to Haemophilus influenzae: observations on pathogenesis and treatment. | 1984-05 |
|
| In vitro activity of fludalanine combined with pentizidone compared with those of other agents. | 1984-05 |
|
| A new and simple method of resolution. Preparation of 3-fluoro-D-alanine-2-d. | 1977-01-07 |
|
| Organofluorine synthesis via photofluorination: 3-fluoro-D-alanine and 2-deuterio analogue, antibacterials related to the bacterial cell wall. | 1976-09-01 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Apr 02 09:21:12 GMT 2025
by
admin
on
Wed Apr 02 09:21:12 GMT 2025
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| Record UNII |
JV76B65O78
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| Record Status |
Validated (UNII)
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| Record Version |
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| Name | Type | Language | ||
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Preferred Name | English | ||
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Official Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C52588
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SUB07677MIG
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C81726
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C045952
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DTXSID801351399
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100000081254
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CHEMBL2111117
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146933
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JV76B65O78
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252-607-7
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35523-45-6
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4306
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
