2-(2-CARBOXYETHYL)-4-METHYL-5-PROPYLFURAN-3-CARBOXYLICACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H16O5
Molecular Weight	240.2524
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of 2-(2-CARBOXYETHYL)-4-METHYL-5-PROPYLFURAN-3-CARBOXYLICACID

Structure Search

SMILES

CCCC1=C(C)C(C(O)=O)=C(CCC(O)=O)O1

InChI

InChIKey=WMCQWXZMVIETAO-UHFFFAOYSA-N

InChI=1S/C12H16O5/c1-3-4-8-7(2)11(12(15)16)9(17-8)5-6-10(13)14/h3-6H2,1-2H3,(H,13,14)(H,15,16)

HIDE SMILES / InChI

Molecular Formula	C12H16O5
Molecular Weight	240.2524
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Solute carrier family 22 member 6 19 Target ID: CHEMBL1641347 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14675047	Substrate 661
Solute carrier family 22 member 8 17 Target ID: CHEMBL1641348 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14675047	Substrate 661

PubMed

Title	Date	PubMed
Proximal tubule cell hypothesis for cardiorenal syndrome in diabetes.	2010-12-09	21197105
Serological cardiovascular and mortality risk predictors in dialysis patients receiving sevelamer: a prospective study.	2010-08	20172849
Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging.	2010-03-03	20199661
Inhibitory effects of uraemic toxins 3-indoxyl sulfate and p-cresol on losartan metabolism in vitro.	2010-01	20723009
Recent progress in the analysis of uremic toxins by mass spectrometry.	2009-09-01	19083276
Protein-bound toxins--update 2009.	2009-08-28	19708977
Evolution of protein-bound uraemic solutes during predilution haemofiltration.	2009-06-27	19557711
Effects of uremic serum and uremic toxins on hepatic uptake of digoxin.	2008-10	18708994
Crystallographic analysis of human serum albumin complexed with 4Z,15E-bilirubin-IXalpha.	2008-08-29	18602119
Influences of haemodialysis on the binding sites of human serum albumin: possibility of an efficacious administration plan using binding inhibition.	2008-07	18390890
Effect of the super-flux cellulose triacetate dialyser membrane on the removal of non-protein-bound and protein-bound uraemic solutes.	2007-07	17468506
[Interpretations of laboratory test data on serum protein binding].	2007-02	17268139
New approaches to the removal of protein-bound toxins from blood plasma of uremic patients.	2007	17573628
Involvement of organic anion transporters in the efflux of uremic toxins across the blood-brain barrier.	2006-02	16445853
Effects of renal failure on drug transport and metabolism.	2006-01	16085315
Liquid chromatographic tandem mass spectrometric assay for the uremic toxin 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid in human plasma.	2006	16628600
Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney.	2005-04	15846473
Differential contributions of rOat1 (Slc22a6) and rOat3 (Slc22a8) to the in vivo renal uptake of uremic toxins in rats.	2005-04	15846470
Effects of uremic toxins on hepatic uptake and metabolism of erythromycin.	2004-11	15286055
Characterization of uremic toxin transport by organic anion transporters in the kidney.	2004-01	14675047
Protein-bound uremic retention solutes.	2003-10	14681860
Renal disposition of a furan dicarboxylic acid and other uremic toxins in the rat.	2002-11	12388676
Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain.	2002-10	12358729
Behavior of non-protein-bound and protein-bound uremic solutes during daily hemodialysis.	2002-08	12148107
Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney.	2002-05	11967025
Effect of protein-bound uraemic toxins on the thermodynamic characteristics of human albumin.	2002-04-01	11960605
Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability.	2001-08	11493579
Protein-bound uremic solutes: the forgotten toxins.	2001-02	11169024

Substance Class	Chemical Created by `admin` on `Tue Apr 01 16:36:37 GMT 2025` Edited by `admin` on `Tue Apr 01 16:36:37 GMT 2025`
Record UNII	JTU41879GF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CMPF

Preferred Name

English

2-(2-CARBOXYETHYL)-4-METHYL-5-PROPYLFURAN-3-CARBOXYLICACID

Systematic Name

English

3-CARBOXY-4-METHYL-5-PROPYL-2-FURANPROPIONIC

Systematic Name

English

PROPYLUROFURANIC ACID

Common Name

English

2-FURANPROPIONIC ACID, 3-CARBOXY-4-METHYL-5-PROPYL-

Systematic Name

English

Code System Code Type Description

CAS

86879-39-2