RepSox

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H13N5
Molecular Weight	287.3186
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC=CC(=N1)C2=NNC=C2C3=CC=C4N=CC=CC4=N3

InChI

InChIKey=LBPKYPYHDKKRFS-UHFFFAOYSA-N

InChI=1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)

HIDE SMILES / InChI

Molecular Formula	C17H13N5
Molecular Weight	287.3186
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
TGF-beta receptor type-1 8 Target ID: P36897 Gene ID: 7046.0 Gene Symbol: TGFBR1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/15317461	Inhibitor 8504		23.0 nM [IC50]

Substance Class	Chemical Created by `admin` on `Wed Apr 02 18:49:57 GMT 2025` Edited by `admin` on `Wed Apr 02 18:49:57 GMT 2025`
Record UNII	JT8ZW3H2ST
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

E 616452

Preferred Name

English

RepSox

Brand Name

English

1,5-Naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-

Systematic Name

English

E-616452

Code

English

TGF-? RI kinase inhibitor II (2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine)

Common Name

English

2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine

Systematic Name

English

SJN-2511

Code

English

Alk 5 Inhibitor II (2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine)

Common Name

English

SJN 2511

Code

English

Code System Code Type Description

CAS

446859-33-2

Created by admin on Wed Apr 02 18:49:57 GMT 2025 , Edited by admin on Wed Apr 02 18:49:57 GMT 2025

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PUBCHEM

449054

Created by admin on Wed Apr 02 18:49:57 GMT 2025 , Edited by admin on Wed Apr 02 18:49:57 GMT 2025

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FDA UNII

JT8ZW3H2ST

Created by admin on Wed Apr 02 18:49:57 GMT 2025 , Edited by admin on Wed Apr 02 18:49:57 GMT 2025

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EPA CompTox

DTXSID80332295

Created by admin on Wed Apr 02 18:49:57 GMT 2025 , Edited by admin on Wed Apr 02 18:49:57 GMT 2025

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