TECHNETIUM TC-99M FURIFOSMIN

First approved in 1973

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H32N2O4.C12H27O3P.Cl.Tc
Molecular Weight	749.153
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	2
Charge	2

SHOW SMILES / InChI

Structure of TECHNETIUM TC-99M FURIFOSMIN

Structure Search

SMILES

[Cl-].[99Tc+3].COCCCP(CCCOC)CCCOC.CC1(C)OC(C)(C)C(\C=N\CC\N=C\C2=C(O)C(C)(C)OC2(C)C)=C1O

InChI

InChIKey=FVQVEDUSERSGQF-JFLDSUQKSA-M

InChI=1S/C20H32N2O4.C12H27O3P.ClH.Tc/c1-17(2)13(15(23)19(5,6)25-17)11-21-9-10-22-12-14-16(24)20(7,8)26-18(14,3)4;1-13-7-4-10-16(11-5-8-14-2)12-6-9-15-3;;/h11-12,23-24H,9-10H2,1-8H3;4-12H2,1-3H3;1H;/q;;;+3/p-1/b21-11+,22-12+;;;/i;;;1+1

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C12H27O3P
Molecular Weight	250.3147
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C20H30N2O4
Molecular Weight	362.4632
Charge	-2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	2
Optical Activity	NONE

Molecular Formula	Tc
Molecular Weight	98.9063
Charge	3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.hindawi.com/journals/stni/2014/839369/
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/books/NBK215133/ | https://www.iaea.org/OurWork/ST/NE/NEFW/Technical-Areas/RRS/documents /mo99/WORKINGMATERIALSmo99CM.pdf | https://www.ncbi.nlm.nih.gov/pubmed/27854401

Molybdenum-99 (99Mo, half-life = 66 h) is a parent radionuclide of a diagnostic nuclear isotope. It decays in technetium-99 m (half-life = 6 h), which is used in over 30 million procedures per year around the world. Between 95 and 98 percent of Mo-99 is currently being produced using highly enriched uranium (HEU) targets. Other medical isotopes such as iodine-131 (I-131) and xenon-133 (Xe-133) are by-products of the Mo-99 production process and will be sufficiently available if Mo-99 is available.

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2578
bone problems 43 Sources: https://www.drugs.com/cons/osteolite.html	Diagnostic	Approved 8429	OSTEOLITE Approved Use Unknown Launch Date 1977
osteogenesis 43 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/018035s032lbl.pdf	Diagnostic	Approved 8429	DRAXIMAGE MDP-10 Approved Use MDP-25 (Kit for the Preparation of Technetium Tc 99m Medronate) may be used as a bone imaging agent to delineate areas of altered osteogenesis. Launch Date 1978

PubMed

Title	Date	PubMed
Future of low specific activity molybdenum-99/technetium-99m generator.	2012 Oct	22642420

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:41:49 GMT 2023` Edited by `admin` on `Fri Dec 15 19:41:49 GMT 2023`
Record UNII	JR82EGZ9G2
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TECHNETIUM TC-99M FURIFOSMIN

Common Name

English

Q-12

Code

English

TECHNETIUM(1+)-99TC, ((4,4'-(1,2-ETHANEDIYLBIS((NITRILO-.KAPPA.N)METHYLIDYNE))BIS(DIHYDRO-2,2,5,5-TETRAMETHYL-3(2H)-FURANONATO-.KAPPA.O3))(2-))BIS(TRIS(3-METHOXYPROPYL)PHOSPHINE-.KAPPA.P)-, CHLORIDE (1:1), (OC-6-13)-

Systematic Name

English

TECHNETIUM (99MTC) FURIFOSMIN

Common Name

English

MP-1554

Code

English

TECHNETIUM TC 99M FURIFOSMIN

Official Name

English

Technetium (99mTc) furifosmin [WHO-DD]

Common Name

English

TECHNETIUM TC 99M FURIFOSMIN [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2124