RETLIRAFUSP ALFA

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 11:31:48 GMT 2025` Edited by `admin` on `Wed Apr 02 11:31:48 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	JP6N6TA92L
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RETLIRAFUSP ALFA

Official Name

English

SHR-1701

Preferred Name

English

Retlirafusp alfa [WHO-DD]

Common Name

English

retlirafusp alfa [INN]

Common Name

English

SHR1701

Code

English

IMMUNOGLOBULIN G4 (52-GLYCINE, 57-PHENYLALANINE, 227-PROLINE, 233-ALANINE, 234-ALANINE, 446-ALANINE), ANTI-(HUMAN PROGRAMMED DEATH-LIGAND 1) (HUMAN-MUS MUSCULUS MONOCLONAL SHR-1316 .GAMMA.4-CHAIN) FUSION PROTEIN WITH PEPTIDE LINKER ((GGGGS)4G) FUSION PRO

Common Name

English

Code System Code Type Description

INN

11662

Created by admin on Wed Apr 02 11:31:48 GMT 2025 , Edited by admin on Wed Apr 02 11:31:48 GMT 2025

PRIMARY

INN

NCI_THESAURUS

C178398

Created by admin on Wed Apr 02 11:31:48 GMT 2025 , Edited by admin on Wed Apr 02 11:31:48 GMT 2025

PRIMARY

SMS_ID

300000038059

Created by admin on Wed Apr 02 11:31:48 GMT 2025 , Edited by admin on Wed Apr 02 11:31:48 GMT 2025

PRIMARY

CAS

2395839-91-3

Created by admin on Wed Apr 02 11:31:48 GMT 2025 , Edited by admin on Wed Apr 02 11:31:48 GMT 2025

PRIMARY

FDA UNII

JP6N6TA92L

Created by admin on Wed Apr 02 11:31:48 GMT 2025 , Edited by admin on Wed Apr 02 11:31:48 GMT 2025

PRIMARY

From	To
1_228	2_228
1_225	2_225
2_133	4_218
1_133	3_218
4_138	4_198
3_138	3_198
4_23	4_92
3_23	3_92
2_563	2_568
2_546	2_561
2_502	2_526
2_486	2_492
2_479	2_496
2_476	2_509
2_366	2_424
2_260	2_320
2_146	2_202
2_22	2_96
1_563	1_568
1_546	1_561
1_502	1_526
1_486	1_492
1_479	1_496
1_476	1_509
1_366	1_424
1_260	1_320
1_146	1_202
1_22	1_96

Glycosylation Link Type	Site
N	1_296
N	1_495
N	1_519
N	1_579
N	2_296
N	2_495
N	2_519
N	2_579

Related Record Type Details


					JP6N6TA92L

RETLIRAFUSP ALFA

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL