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Details

Stereochemistry ACHIRAL
Molecular Formula C6H2I2NO3.Na
Molecular Weight 412.8837
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DISOPHENOL SODIUM

SMILES

[Na+].[O-]C1=C(I)C=C(C=C1I)[N+]([O-])=O

InChI

InChIKey=SRSIPZANKZYBTO-UHFFFAOYSA-M
InChI=1S/C6H3I2NO3.Na/c7-4-1-3(9(11)12)2-5(8)6(4)10;/h1-2,10H;/q;+1/p-1

HIDE SMILES / InChI
Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C6H2I2NO3
Molecular Weight 389.8939
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Disophenol is a drug used in veterinary medicine recommended for use in the treatment of dogs infested with hook worms (Ancylostoma caninum, A. braziliense and Uncinuriu stenocephala) and cats infested with the hookworm A. tubaeforme.

Originator

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
Inhibitor
8297
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8429
ANCYLOL

Approved Use

The drug is used for the treatment of both dogs infested with hookworms (including Ancylostoma caninum, A. braziliense and Uncinaria stenocephala) and cats infested with the hookworm A. tubaeforme.

Launch Date

1964
PubMed

PubMed

TitleDatePubMed
2,6-Diiodo-4-nitrophenol, 2,6-diiodo-4-nitrophenyl acetate and 2,6-diiodo-4-nitroanisole: interplay of hydrogen bonds, iodo-nitro interactions and aromatic pi-pi-stacking interactions to give supramolecular structures in one, two and three dimensions.
2002 Aug
Patents

Patents

JP2010515781A
2

Sample Use Guides

In Vivo Use Guide
Dogs and cats: Disophenol is administered subcutaneously at a dosage level equivalent to 4.5 milligrams of disophenol per pound of body weight. A second treatment may be indicated 21 days after the initial treatment.
Route of Administration: Other
In Vitro Use Guide
Disophenol produced contracture of the rat cardiac muscle at concentrations of 100 and 1000 ng/ml and at the latter dose diastolic tension after 60 min perfusion was approximately 300 per cent of its initial value.
Substance Class Chemical
Created
by admin
on Fri Dec 15 20:13:19 GMT 2023
Edited
by admin
on Fri Dec 15 20:13:19 GMT 2023
Record UNII
JOS947MY69
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DISOPHENOL SODIUM
GREEN BOOK  
Common Name English
SODIUM, (2,6-DIIODO-4-NITROPHENOXY)-
Systematic Name English
PHENOL, 2,6-DIIODO-4-NITRO-, SODIUM SALT (1:1)
Common Name English
DISOPHENOL SODIUM [GREEN BOOK]
Common Name English
Code System Code Type Description
CAS
89465-91-8
Created by admin on Fri Dec 15 20:13:19 GMT 2023 , Edited by admin on Fri Dec 15 20:13:19 GMT 2023
PRIMARY
EPA CompTox
DTXSID50237748
Created by admin on Fri Dec 15 20:13:19 GMT 2023 , Edited by admin on Fri Dec 15 20:13:19 GMT 2023
PRIMARY
PUBCHEM
14339440
Created by admin on Fri Dec 15 20:13:19 GMT 2023 , Edited by admin on Fri Dec 15 20:13:19 GMT 2023
PRIMARY
FDA UNII
JOS947MY69
Created by admin on Fri Dec 15 20:13:19 GMT 2023 , Edited by admin on Fri Dec 15 20:13:19 GMT 2023
PRIMARY
NIH
NCATS
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