Ziclumeran

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 19:15:30 GMT 2023` Edited by `admin` on `Sat Dec 16 19:15:30 GMT 2023`
Nucleic Acid Type	MRNA
Nucleic Acid Subtype	TRANSGENE
Sequence Type	COMPLETE
Record UNII	JJ5AS2HL3G
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Ziclumeran

Official Name

English

messenger RNA (mRNA), 5' capped, encoding codon-optimised clustered regularly interspaced short palindromic repeats (CRISPR) associated protein 9 (Cas9), flanked by untranslated regions (UTR) with significant sequence homology to the Xenopus beta globin

Common Name

English

RNA (recombinant 5′-(m7Gm-(5′→5′)-ppp-G)-capped all uridine→N1-methylpseudouridine-substituted synthetic CRISPR-associated endodeoxyribonuclease CAS9 low codon A-optimized-specifying plus Xenopus laevis β-globin 5′-and 3′-untranslated flan

Common Name

English

ziclumeran [INN]

Common Name

English

cas9 mRNA

Common Name

English

Code System Code Type Description

FDA UNII

JJ5AS2HL3G

Created by admin on Sat Dec 16 19:15:30 GMT 2023 , Edited by admin on Sat Dec 16 19:15:30 GMT 2023

PRIMARY

CAS

2305431-29-0

Created by admin on Sat Dec 16 19:15:30 GMT 2023 , Edited by admin on Sat Dec 16 19:15:30 GMT 2023

PRIMARY

INN

12328

Created by admin on Sat Dec 16 19:15:30 GMT 2023 , Edited by admin on Sat Dec 16 19:15:30 GMT 2023

PRIMARY

Sugar	Site Range	Site Count
D-Ribose (RNA)	1_1-1_4423	4423 / 4423

Linkage	Site Range	Site Count
Phosphate	1_2-1_4423	4422 / 4422

Related Record Type Details


					HB8LE6H4UK

Ziclumeran expressed CRISPR-associated protein 9

EXPRESSED PROTEIN->VECTOR

Amount:

Related Record Type Details


					JJ5AS2HL3G

Ziclumeran

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE_SUBSTITUTION		RESIDUE_SPECIFIC	U		N1-METHYLPSEUDOURIDINE	09RAD4M6WF
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS			7-methyl(3'-O-methyl)GpppGP cap	427EK6X4GY