THONZONIUM BROMIDE

First approved in 1953

Details

Stereochemistry	ACHIRAL
Molecular Formula	C32H55N4O.Br
Molecular Weight	591.709
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Br-].CCCCCCCCCCCCCCCC[N+](C)(C)CCN(CC1=CC=C(OC)C=C1)C2=NC=CC=N2

InChI

InChIKey=WBWDWFZTSDZAIG-UHFFFAOYSA-M

InChI=1S/C32H55N4O.BrH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-27-36(2,3)28-26-35(32-33-24-19-25-34-32)29-30-20-22-31(37-4)23-21-30;/h19-25H,5-18,26-29H2,1-4H3;1H/q+1;/p-1

HIDE SMILES / InChI

Molecular Formula	BrH
Molecular Weight	80.912
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C32H55N4O
Molecular Weight	511.8053
Charge	1
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/050356s050lbl.pdf | https://www.ncbi.nlm.nih.gov/pubmed/26906912

Thonzonium Bromide is a cationic surface-active compound. As an additive to pharmacologic formulations, thonzonium bromide causes dispersion and penetration of cellular debris and exudate, thereby promoting tissue contact of the administered medication. Thonzonium bromide is a component of FDA-approved Coly-Mycin S Otic, used for treating infections of the ear caused by certain bacteria. It has being shown that Thonzonium bromide inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo, suggesting that Thonzonium bromide might be a useful alternative therapy in preventing or treating osteolytic diseases..

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
osteoclast development 5 Target ID: GO:0036035 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26906912	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Superficial bacterial infections of the external auditory canal 5 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/050356s050lbl.pdf	Curative		Approved 8429	COLY-MYCIN S Approved Use Cortisporin®-TC Otic Suspension is indicated for the treatment of superficial bacterial infections of the external auditory canal, caused by organisms susceptible to the action of the antibiotics; and for the treatment of infections of mastoidectomy and fenestration cavities, caused by organisms susceptible to the antibiotics. Launch Date -2.40710402E11
Bone osteolytic diseases 2 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26906912	Primary		Preclinical	Unknown Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
1PlusChem LLC	1P00DBQ0
ABI Chem	AC1L1KDZ
AK Scientific	2755AH
AbovChem LLC	HY-B1246
Angene	AGN-PC-0WH4Z4
BLD Pharm	BD133136
BOC Sciences	553-08-2
Chem Scene	CS-4957
Compound Cloud	11102
Compound Cloud	5456
HongKong Chemhere	553-08-2
MedChem Express	HY-B1246
MolPort	MolPort-006-111-785
Molnova	M15007
NCI Plated 2007	5648
Ryan Scientific	Ruxolitinib_(INCB-18424)_phosphate
TargetMol	T2188
Tetrahedron	TS84031
ZINC	ZINC000008035268	http://zinc15.docking.org/substances/ZINC000008035268
eMolecules	193738071
eMolecules	6719999
mcule	MCULE-5940047784
mcule	MCULE-9476000904

PubMed

Title	Date	PubMed
Thermal decomposition of thonzonium bromide.	1986 Oct	24271714
Inhibitors of V-ATPase proton transport reveal uncoupling functions of tether linking cytosolic and membrane domains of V0 subunit a (Vph1p).	2012 Mar 23	22215674
Thonzonium bromide inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo.	2016 Mar 15	26906912

Patents

Sample Use Guides

In Vivo Use Guide

Mice: 5 mg/kg body weight, subcutaneous injection

Route of Administration: Other

In Vitro Use Guide

Mature osteoclasts (OCs) exposed to Thonzonium (100 or 200 nM) for 48 h demonstrated attenuated capacity to resorb bone (reduction of 30% and 80% respectively).

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:10:17 UTC 2023` Edited by `admin` on `Fri Dec 15 15:10:17 UTC 2023`
Record UNII	JI2B19CR0R
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

THONZONIUM BROMIDE

Official Name

English

THONZONIUM BROMIDE [USP-RS]

Common Name

English

TONZONIUM BROMIDE [MART.]

Common Name

English

THONZONIUM BROMIDE [MI]

Common Name

English

NC-1264

Code

English

COLY-MYCIN S COMPONENT THONZONIUM BROMIDE

Common Name

English

THONZONIUM BROMIDE [USAN]

Common Name

English

THONZONIUM BROMIDE [ORANGE BOOK]

Common Name

English

THONZONIUM BROMIDE [VANDF]

Common Name

English

NC 1264

Code

English

HEXADECYL(2-((P-METHOXYBENZYL)-2-PYRIMIDINYLAMINO)ETHYL)DIMETHYLAMMONIUM BROMIDE

Common Name

English

1-HEXADECANAMINIUM, N-(2-(((4-METHOXYPHENYL)METHYL)-2-PYRIMIDINYLAMINO)ETHYL)-N,N-DIMETHYL-, BROMIDE

Systematic Name

English

Tonzonium bromide [WHO-DD]

Common Name

English

tonzonium bromide [INN]

Common Name

English

THONZIDE

Brand Name

English

NSC-5648

Code

English

THONZONIUM BROMIDE COMPONENT OF COLY-MYCIN S

Common Name

English

TONZONIUM BROMIDE

Official Name

English

Classification Tree Code System Code

NCI_THESAURUS

C83486