Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C28H36N2O4.4H2O |
| Molecular Weight | 536.6576 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.O.O.[H][C@]3(CC1=NCCC2=C1C=C(OC)C(O)=C2)C[C@]4([H])N(CCC5=C4C=C(OC)C(OC)=C5)C[C@@H]3CC
InChI
InChIKey=KNTXBHOZBKSJNQ-XITUUATBSA-N
InChI=1S/C28H36N2O4.4H2O/c1-5-17-16-30-9-7-19-13-27(33-3)28(34-4)15-22(19)24(30)11-20(17)10-23-21-14-26(32-2)25(31)12-18(21)6-8-29-23;;;;/h12-15,17,20,24,31H,5-11,16H2,1-4H3;4*1H2/t17-,20-,24-;;;;/m0..../s1
| Molecular Formula | H2O |
| Molecular Weight | 18.0153 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C28H36N2O4 |
| Molecular Weight | 464.5964 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/1721050 | http://www.ncbi.nlm.nih.gov/pubmed/10643674 | http://www.ncbi.nlm.nih.gov/pubmed/10843602
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/1721050 | http://www.ncbi.nlm.nih.gov/pubmed/10643674 | http://www.ncbi.nlm.nih.gov/pubmed/10843602
Psychotrine is an alkaloid isolated from stems of Pogonopus speciosus, roots of Cephaelis acuminata, dried fruits of Alangium lamarckii. Psychotrine shows weak cytotoxic activity against a panel of human cancer cell lines. Psychotrine demonstrated inhibition of HIV-1 RT in micromolar concentrations.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Psychotrine and its O-methyl ether are selective inhibitors of human immunodeficiency virus-1 reverse transcriptase. | 1991 Dec 15 |
|
| Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. | 1991 Jan-Feb |
|
| HIV-1 and HIV-2 reverse transcriptases: a comparative study of sensitivity to inhibition by selected natural products. | 1992 May 29 |
|
| 1',2',3',4'-tetradehydrotubulosine, a cytotoxic alkaloid from Pogonopus speciosus. | 1999 Sep |
Patents
Sample Use Guides
Recombinant HIV-1 RT, expressed in E. coli was used. Assay mixture, containing Tris*HCl buffer (pH 8.0), KCl, MgCl2, EGTA,ditriothreitol, glutathione, BSA, poly(rA), oligo (dT), Triton X-100, TTP and [3H]TTP, was prepared. Serial dilution of samples dissolved in H2O or DMSO were added to the reaction mixtures. The reaction was initiated by the addition of 10 uL of HIV-1RT, and the mixture was incubated at 37C for 1h. Reaction was terminated by the addition of EGTA following by chilling in ice. Aliquotes of reaction mixture wre spotted on whatman filters, washed and subjected to scintillation counting.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 00:42:44 GMT 2023
by
admin
on
Sat Dec 16 00:42:44 GMT 2023
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| Record UNII |
JH3Q4LM69J
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| Record Status |
Validated (UNII)
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| Record Version |
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m9308
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JH3Q4LM69J
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6199-09-3
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ANHYDROUS->SOLVATE | |||
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PARENT -> SALT/SOLVATE |
