KOKUSAGININE

COC1=CC2=C(C=C1OC)C(OC)=C3C=COC3=N2

InChIKey=JBRXRVFXQIKPEA-UHFFFAOYSA-N

InChI=1S/C14H13NO4/c1-16-11-6-9-10(7-12(11)17-2)15-14-8(4-5-19-14)13(9)18-3/h4-7H,1-3H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Potency
Tubulin 69 Target ID: CHEMBL2095182 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29903663	Binding Agent 1064
Apoptosis 155 Target ID: map04210 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29903663	Activator 1430
Acetylcholinesterase 207 Target ID: CHEMBL4078 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26434116	Inhibitor 8297	28.2 µM [IC50]

PubMed

Title	Date	PubMed
Antibacterial constituents of three Cameroonian medicinal plants: Garcinia nobilis, Oricia suaveolens and Balsamocitrus camerunensis.	2013 Apr 10	23574627
Furoquinoline alkaloids isolated from Balfourodendron riedelianum as photosynthetic inhibitors in spinach chloroplasts.	2013 Mar 5	23416711
Cytotoxic Benzophenanthridine and Furoquinoline Alkaloids from Zanthoxylum buesgenii (Rutaceae).	2014	25349626
Inhibition of hepatitis C virus replication by chalepin and pseudane IX isolated from Ruta angustifolia leaves.	2014 Dec	25454460
Phytochemicals from Ruta graveolens Activate TAS2R Bitter Taste Receptors and TRP Channels Involved in Gustation and Nociception.	2015 Oct 16	26501253
Chalepin: isolated from Ruta angustifolia L. Pers induces mitochondrial mediated apoptosis in lung carcinoma cells.	2016 Oct 12	27729078
The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly.	2018 Aug 1	29903663
Determination of antibacterial activity and metabolite profile of Ruta graveolens against Streptococcus mutans and Streptococcus sobrinus.	2018 Jul-Sep	30078970
Furoquinolines and dihydrooxazole alkaloids with cytotoxic activity from the stem bark of Araliopsis soyauxii.	2019 Mar	30654126

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:45:23 GMT 2023` Edited by `admin` on `Fri Dec 15 17:45:23 GMT 2023`
Record UNII	JG1753DK5H
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

KOKUSAGININE

Common Name

English

KOKUSAGININ

Common Name

English

FURO(2,3-B)QUINOLINE, 4,6,7-TRIMETHOXY-

Systematic Name

English

6,7-DIMETHOXYDICTAMNINE

Systematic Name

English

4,6,7-TRIMETHOXYFURO(2,3-B)QUINOLINE

Systematic Name

English

NSC-103013

Code

English

Code System Code Type Description

NSC

103013