KOKUSAGININE

COC1=C(OC)C=C2C(=C1)N=C3OC=CC3=C2OC

InChIKey=JBRXRVFXQIKPEA-UHFFFAOYSA-N

InChI=1S/C14H13NO4/c1-16-11-6-9-10(7-12(11)17-2)15-14-8(4-5-19-14)13(9)18-3/h4-7H,1-3H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Potency
Tubulin 69 Target ID: CHEMBL2095182 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29903663	Binding Agent 1076
Apoptosis 156 Target ID: map04210 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29903663	Activator 1447
Acetylcholinesterase 209 Target ID: CHEMBL4078 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26434116	Inhibitor 8504	28.2 µM [IC50]

PubMed

Title	Date	PubMed
Furoquinolines and dihydrooxazole alkaloids with cytotoxic activity from the stem bark of Araliopsis soyauxii.	2019-03	30654126
Determination of antibacterial activity and metabolite profile of Ruta graveolens against Streptococcus mutans and Streptococcus sobrinus.	2018-08-07	30078970
The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly.	2018-08-01	29903663
Chalepin: isolated from Ruta angustifolia L. Pers induces mitochondrial mediated apoptosis in lung carcinoma cells.	2016-10-12	27729078
Phytochemicals from Ruta graveolens Activate TAS2R Bitter Taste Receptors and TRP Channels Involved in Gustation and Nociception.	2015-10-16	26501253
Furoquinoline Alkaloids from the Leaves of Evodia lepta as Potential Cholinesterase Inhibitors and their Molecular Docking.	2015-08	26434116
Inhibition of hepatitis C virus replication by chalepin and pseudane IX isolated from Ruta angustifolia leaves.	2014-12	25454460
Cytotoxic Benzophenanthridine and Furoquinoline Alkaloids from Zanthoxylum buesgenii (Rutaceae).	2014	25349626
Antibacterial constituents of three Cameroonian medicinal plants: Garcinia nobilis, Oricia suaveolens and Balsamocitrus camerunensis.	2013-04-10	23574627
Furoquinoline alkaloids isolated from Balfourodendron riedelianum as photosynthetic inhibitors in spinach chloroplasts.	2013-03-05	23416711

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:51:37 GMT 2025` Edited by `admin` on `Mon Mar 31 18:51:37 GMT 2025`
Record UNII	JG1753DK5H
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

KOKUSAGININE

Common Name

English

NSC-103013

Preferred Name

English

KOKUSAGININ

Common Name

English

FURO(2,3-B)QUINOLINE, 4,6,7-TRIMETHOXY-

Systematic Name

English

6,7-DIMETHOXYDICTAMNINE

Systematic Name

English

4,6,7-TRIMETHOXYFURO(2,3-B)QUINOLINE

Systematic Name

English

Code System Code Type Description

NSC

103013